Exploiting the Protein Corona around Gold Nanorods for Loading and Triggered Release

ACS Nano ◽  
2012 ◽  
Vol 6 (8) ◽  
pp. 6730-6740 ◽  
Author(s):  
James Chen Yong Kah ◽  
John Chen ◽  
Angel Zubieta ◽  
Kimberly Hamad-Schifferli
Keyword(s):  
Gold Nanorods ◽  
Protein Corona ◽  
Triggered Release

Protein Corona around Gold Nanorods as a Drug Carrier for Multimodal Cancer Therapy

2017 ◽  
Vol 3 (6) ◽  
pp. 1039-1050 ◽  
Author(s):  
Eugenia Li Ling Yeo ◽  
Joshua U-Jin Cheah ◽  
Bing Yi Lim ◽  
Patricia Soo Ping Thong ◽  
Khee Chee Soo ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Gold Nanorods ◽  
Drug Carrier ◽  
Protein Corona

Time evolution and dynamic cellular uptake of PEGYlated gold nanorods

RSC Advances ◽  
2016 ◽  
Vol 6 (10) ◽  
pp. 8089-8092 ◽  
Author(s):  
Hongyuan Song ◽  
Qingqiang Xu ◽  
Hongwei Di ◽  
Ting Guo ◽  
Zhongtian Qi ◽  
...  
Keyword(s):  
Time Evolution ◽  
Cellular Uptake ◽  
Gold Nanorods ◽  
Protein Corona

The protein corona formed and evolved of PEGYlated GNRs which alter GNRs characteristics significantly leading to dynamic cellular uptake pathways.

scholarly journals Gold nanorods coated with a thermo-responsive poly(ethylene glycol)-b-poly(N-vinylcaprolactam) corona as drug delivery systems for remotely near infrared-triggered release

2014 ◽  
Vol 5 (3) ◽  
pp. 799-813 ◽  
Author(s):  
Ji Liu ◽  
Christophe Detrembleur ◽  
Marie-Claire De Pauw-Gillet ◽  
Stéphane Mornet ◽  
Etienne Duguet ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Gold Nanorods ◽  
Drug Delivery Systems ◽  
Near Infrared ◽  
Delivery Systems ◽  
Poly Ethylene Glycol ◽  
Triggered Release ◽  
Poly Ethylene

Remote Triggered Release of Doxorubicin in Tumors by Synergistic Application of Thermosensitive Liposomes and Gold Nanorods

ACS Nano ◽  
2011 ◽  
Vol 5 (6) ◽  
pp. 4919-4926 ◽  
Author(s):  
Abhiruchi Agarwal ◽  
Megan A. Mackey ◽  
Mostafa A. El-Sayed ◽  
Ravi V. Bellamkonda
Keyword(s):  
Gold Nanorods ◽  
Triggered Release ◽  
Thermosensitive Liposomes

Light-independent M1 macrophage polarization by photosensitizer-loaded protein corona on gold nanorods

Nanomedicine ◽  
2020 ◽  
Vol 15 (24) ◽  
pp. 2329-2344
Author(s):  
Joshua U-Jin Cheah ◽  
Heng Boon Low ◽  
Yongliang Zhang ◽  
James Chen Yong Kah
Keyword(s):  
Protein Expression ◽  
Cell Viability ◽  
Gold Nanorods ◽  
Inductively Coupled Plasma ◽  
Macrophage Polarization ◽  
Protein Corona ◽  
Cell Viability Assay ◽  
M1 Polarization ◽  
M1 Macrophage ◽  
Gene And Protein Expression

Aim: To establish a light-independent functionality of gold nanorods (AuNRs) with a human serum (HS) protein corona loaded with photosensitizer Chlorin e6 (AuNR-HS-Ce6) in M1 polarization of macrophages. Methods: RT-qPCR and ELISA were used to determine gene and protein expression, respectively. Uptake of AuNR-HS-Ce6 was determined via flow cytometry, inductively coupled plasma mass spectrometry and fluorescence microscopy. Cell viability was determined using PrestoBlue® cell viability assay. Results: An increase in M1 gene and protein expression was observed in AuNR-HS-Ce6-treated macrophages. Delivery of high Ce6 payload via AuNR-HS-Ce6 was the primary contributor toward M1 polarization. Finally, DLD-1 cells treated with conditioned media from AuNR-HS-Ce6-treated macrophages showed significantly reduced proliferation. Conclusion: Our study suggests an immunomodulatory potential of Ce6 in inducing light-independent M1 polarization outside of its role as a photosensitizer.

Protein corona influences liver accumulation and hepatotoxicity of gold nanorods

NanoImpact ◽  
2016 ◽  
Vol 3-4 ◽  
pp. 40-46 ◽  
Author(s):  
Huatang Cai ◽  
Yuhui Ma ◽  
Ziran Wu ◽  
Yayun Ding ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Protein Corona

Gold Nanorods Coated with Apolipoprotein E Protein Corona for Drug Delivery

2019 ◽  
Vol 2 (10) ◽  
pp. 6220-6229 ◽  
Author(s):  
Eugenia Li Ling Yeo ◽  
Joshua U-Jin Cheah ◽  
Patricia Soo Ping Thong ◽  
Khee Chee Soo ◽  
James Chen Yong Kah
Keyword(s):  
Drug Delivery ◽  
Apolipoprotein E ◽  
Gold Nanorods ◽  
Protein Corona ◽  
E Protein
Sign in / Sign up

Export Citation Format

Share Document