Remote Triggered Release of Doxorubicin in Tumors by Synergistic Application of Thermosensitive Liposomes and Gold Nanorods

ACS Nano ◽  
2011 ◽  
Vol 5 (6) ◽  
pp. 4919-4926 ◽  
Author(s):  
Abhiruchi Agarwal ◽  
Megan A. Mackey ◽  
Mostafa A. El-Sayed ◽  
Ravi V. Bellamkonda
Keyword(s):  
Gold Nanorods ◽  
Triggered Release ◽  
Thermosensitive Liposomes

Thermally triggered release of a pro-osteogenic peptide from a functionalized collagen-based scaffold using thermosensitive liposomes

2014 ◽  
Vol 187 ◽  
pp. 158-166 ◽  
Author(s):  
Adolfo López-Noriega ◽  
Eduardo Ruiz-Hernández ◽  
Elaine Quinlan ◽  
Gert Storm ◽  
Wim E. Hennink ◽  
...  
Keyword(s):  
Triggered Release ◽  
Thermosensitive Liposomes ◽  
Thermally Triggered

scholarly journals Gold nanorods coated with a thermo-responsive poly(ethylene glycol)-b-poly(N-vinylcaprolactam) corona as drug delivery systems for remotely near infrared-triggered release

2014 ◽  
Vol 5 (3) ◽  
pp. 799-813 ◽  
Author(s):  
Ji Liu ◽  
Christophe Detrembleur ◽  
Marie-Claire De Pauw-Gillet ◽  
Stéphane Mornet ◽  
Etienne Duguet ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Gold Nanorods ◽  
Drug Delivery Systems ◽  
Near Infrared ◽  
Delivery Systems ◽  
Poly Ethylene Glycol ◽  
Triggered Release ◽  
Poly Ethylene

scholarly journals Thermosensitive liposomes for triggered release of cytotoxic proteins

2018 ◽  
Vol 132 ◽  
pp. 211-221 ◽  
Author(s):  
Maria B.C. de Matos ◽  
Nataliia Beztsinna ◽  
Christoph Heyder ◽  
Marcel H.A.M. Fens ◽  
Enrico Mastrobattista ◽  
...  
Keyword(s):  
Triggered Release ◽  
Cytotoxic Proteins ◽  
Thermosensitive Liposomes

scholarly journals Thermosensitive Liposomes Modified with Poly(N-isopropylacrylamide-co-propylacrylic acid) Copolymers for Triggered Release of Doxorubicin

2010 ◽  
Vol 11 (8) ◽  
pp. 1915-1920 ◽  
Author(s):  
Terence Ta ◽  
Anthony J. Convertine ◽  
Christopher R. Reyes ◽  
Patrick S. Stayton ◽  
Tyrone M. Porter
Keyword(s):  
Triggered Release ◽  
Thermosensitive Liposomes

scholarly journals Heat-activated nanomedicine formulation improves the anticancer potential of the HSP90 inhibitor luminespib in vitro

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Brittany Epp-Ducharme ◽  
Michael Dunne ◽  
Linyu Fan ◽  
James C. Evans ◽  
Lubabah Ahmed ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Chemical Properties ◽  
Heat Shock Protein 90 ◽  
Hsp90 Inhibitor ◽  
Synergistic Activity ◽  
Triggered Release ◽  
Optimal Drug ◽  
Thermosensitive Liposomes

AbstractThe heat shock protein 90 inhibitor, luminespib, has demonstrated potent preclinical activity against numerous cancers. However, clinical translation has been impeded by dose-limiting toxicities that have necessitated dosing schedules which have reduced therapeutic efficacy. As such, luminespib is a prime candidate for reformulation using advanced drug delivery strategies that improve tumor delivery efficiency and limit off-target side effects. Specifically, thermosensitive liposomes are proposed as a drug delivery strategy capable of delivering high concentrations of drug to the tumor in combination with other chemotherapeutic molecules. Indeed, this work establishes that luminespib exhibits synergistic activity in lung cancer in combination with standard of care drugs such as cisplatin and vinorelbine. While our research team has previously developed thermosensitive liposomes containing cisplatin or vinorelbine, this work presents the first liposomal formulation of luminespib. The physico-chemical properties and heat-triggered release of the formulation were characterized. Cytotoxicity assays were used to determine the optimal drug ratios for treatment of luminespib in combination with cisplatin or vinorelbine in non-small cell lung cancer cells. The formulation and drug combination work presented in this paper offer the potential for resuscitation of the clinical prospects of a promising anticancer agent.

scholarly journals Deep Penetrating Triggered Release Nanoparticles As Tumor Radiosensitizers

2018 ◽  
Author(s):  
Sunil Krishnan
Keyword(s):  
Radiation Dose ◽  
Preliminary Data ◽  
Release Kinetics ◽  
Triggered Release ◽  
Dose Enhancement ◽  
Fractionated Radiotherapy ◽  
Multiple Tumor ◽  
Gold Nps ◽  
Thermosensitive Liposomes

Irradiation of tumors laden with gold nanoparticle (NP) results in radiation dose enhancement via increased secondary electron showers emanating from particleradiation interactions. However, it is challenging to load tumors non-invasively with adequate gold to realize the true potential for radiosensitization. In preliminary data we demonstrate that thermosensitive liposomes (TSLs) laden with gold NPs accumulate within cancers via their leaky vasculature. Mild hyperthermia (42οC) induced by FUS leads to rupture of liposomes and deployment of the gold payload deep within tumors. Subsequent radiation results in significant delay in tumor regrowth (radiosensitization). We hypothesize that this is mediated by deep-penetrating gold NPs and the radiation dose enhancement by secondary photo- and Auger- electrons. In preliminary data, we demonstrate successful fabrication of TSLs with gold NPs, their release kinetics upon heating, hyperthermia generation in vivo using FUS, and radiosensitization via triggered release of gold NPs. To test the hypothesis that this is mediated by deep-penetrating gold NPs, we propose in vivo biodistribution experiments using scanning electron microscopy and inductively-coupled plasma mass spectrometry of tumor core vs. periphery in mice treated with gold-ladern TSLs with and without FUS-hyperthermia. We also propose more detailed in vivo experiments using non-thermosensitive liposomes as control. Lastly, we define optimal parameters for maximal delivery of deep-penetrating gold NPs within tumors and synergy when this is coupled with clinically relevant fractionated radiotherapy regimens. Once completed, these studies will provide the framework for development of a readily deployable class solution for radiosensitization of multiple tumor types using TSLs laden with gold.

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