Revealing the Binding Structure of the Protein Corona on Gold Nanorods Using Synchrotron Radiation-Based Techniques: Understanding the Reduced Damage in Cell Membranes

2013 ◽  
Vol 135 (46) ◽  
pp. 17359-17368 ◽  
Author(s):  
Liming Wang ◽  
Jingyuan Li ◽  
Jun Pan ◽  
Xiumei Jiang ◽  
Yinglu Ji ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Gold Nanorods ◽  
Cell Membranes ◽  
Protein Corona ◽  
Binding Structure

scholarly journals Conformational-transited protein corona regulated cell-membrane penetration and induced cytotoxicity of ultrasmall Au nanoparticles

RSC Advances ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 4435-4444 ◽  
Author(s):  
Huayan Yang ◽  
Meng Wang ◽  
Yanmin Zhang ◽  
Feng Li ◽  
Shaoning Yu ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cell Membranes ◽  
Au Nanoparticles ◽  
Protein Corona ◽  
Membrane Disruption ◽  
Membrane Penetration

This study demonstrate that the AuNP–HSA corona could penetrate cell membranes and companied by substantial membrane disruption. However, the ultrasmall AuNPs can be internalized by cells without the destruction of cell membranes.

Protein Corona around Gold Nanorods as a Drug Carrier for Multimodal Cancer Therapy

2017 ◽  
Vol 3 (6) ◽  
pp. 1039-1050 ◽  
Author(s):  
Eugenia Li Ling Yeo ◽  
Joshua U-Jin Cheah ◽  
Bing Yi Lim ◽  
Patricia Soo Ping Thong ◽  
Khee Chee Soo ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Gold Nanorods ◽  
Drug Carrier ◽  
Protein Corona

Revealing Rotational Modes of Functionalized Gold Nanorods on Live Cell Membranes

Small ◽  
2012 ◽  
Vol 9 (5) ◽  
pp. 785-792 ◽  
Author(s):  
Yan Gu ◽  
Wei Sun ◽  
Gufeng Wang ◽  
Michael T. Zimmermann ◽  
Robert L. Jernigan ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Cell Membranes ◽  
Live Cell

Time evolution and dynamic cellular uptake of PEGYlated gold nanorods

RSC Advances ◽  
2016 ◽  
Vol 6 (10) ◽  
pp. 8089-8092 ◽  
Author(s):  
Hongyuan Song ◽  
Qingqiang Xu ◽  
Hongwei Di ◽  
Ting Guo ◽  
Zhongtian Qi ◽  
...  
Keyword(s):  
Time Evolution ◽  
Cellular Uptake ◽  
Gold Nanorods ◽  
Protein Corona

The protein corona formed and evolved of PEGYlated GNRs which alter GNRs characteristics significantly leading to dynamic cellular uptake pathways.

Light-independent M1 macrophage polarization by photosensitizer-loaded protein corona on gold nanorods

Nanomedicine ◽  
2020 ◽  
Vol 15 (24) ◽  
pp. 2329-2344
Author(s):  
Joshua U-Jin Cheah ◽  
Heng Boon Low ◽  
Yongliang Zhang ◽  
James Chen Yong Kah
Keyword(s):  
Protein Expression ◽  
Cell Viability ◽  
Gold Nanorods ◽  
Inductively Coupled Plasma ◽  
Macrophage Polarization ◽  
Protein Corona ◽  
Cell Viability Assay ◽  
M1 Polarization ◽  
M1 Macrophage ◽  
Gene And Protein Expression

Aim: To establish a light-independent functionality of gold nanorods (AuNRs) with a human serum (HS) protein corona loaded with photosensitizer Chlorin e6 (AuNR-HS-Ce6) in M1 polarization of macrophages. Methods: RT-qPCR and ELISA were used to determine gene and protein expression, respectively. Uptake of AuNR-HS-Ce6 was determined via flow cytometry, inductively coupled plasma mass spectrometry and fluorescence microscopy. Cell viability was determined using PrestoBlue® cell viability assay. Results: An increase in M1 gene and protein expression was observed in AuNR-HS-Ce6-treated macrophages. Delivery of high Ce6 payload via AuNR-HS-Ce6 was the primary contributor toward M1 polarization. Finally, DLD-1 cells treated with conditioned media from AuNR-HS-Ce6-treated macrophages showed significantly reduced proliferation. Conclusion: Our study suggests an immunomodulatory potential of Ce6 in inducing light-independent M1 polarization outside of its role as a photosensitizer.

Protein corona influences liver accumulation and hepatotoxicity of gold nanorods

NanoImpact ◽  
2016 ◽  
Vol 3-4 ◽  
pp. 40-46 ◽  
Author(s):  
Huatang Cai ◽  
Yuhui Ma ◽  
Ziran Wu ◽  
Yayun Ding ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Protein Corona

Gold Nanorods Coated with Apolipoprotein E Protein Corona for Drug Delivery

2019 ◽  
Vol 2 (10) ◽  
pp. 6220-6229 ◽  
Author(s):  
Eugenia Li Ling Yeo ◽  
Joshua U-Jin Cheah ◽  
Patricia Soo Ping Thong ◽  
Khee Chee Soo ◽  
James Chen Yong Kah
Keyword(s):  
Drug Delivery ◽  
Apolipoprotein E ◽  
Gold Nanorods ◽  
Protein Corona ◽  
E Protein
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