Recoverable Bismuth-Based Microrobots: Capture, Transport, and On-Demand Release of Heavy Metals and an Anticancer Drug in Confined Spaces

2019 ◽  
Vol 11 (14) ◽  
pp. 13359-13369 ◽  
Author(s):  
Seyyed Mohsen Beladi-Mousavi ◽  
Bahareh Khezri ◽  
Ludmila Krejčová ◽  
Zbyněk Heger ◽  
Zdeněk Sofer ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Anticancer Drug ◽  
Confined Spaces ◽  
On Demand

Smart pH/Redox Dual-Responsive Nanogels for On-Demand Intracellular Anticancer Drug Release

2016 ◽  
Vol 8 (12) ◽  
pp. 7729-7738 ◽  
Author(s):  
Hao Yang ◽  
Qin Wang ◽  
Shan Huang ◽  
Ai Xiao ◽  
Fuying Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Anticancer Drug ◽  
On Demand ◽  
Dual Responsive

An agglutinate magnetic spray transforms inanimate objects into millirobots for biomedical applications

2020 ◽  
Vol 5 (48) ◽  
pp. eabc8191
Author(s):  
Xiong Yang ◽  
Wanfeng Shang ◽  
Haojian Lu ◽  
Yanting Liu ◽  
Liu Yang ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Magnetic Film ◽  
Diverse Range ◽  
One Dimensional ◽  
3D Objects ◽  
Confined Spaces ◽  
On Demand ◽  
Minimalist Approach ◽  
Catheter Navigation ◽  
Original Size

Millirobots that can adapt to unstructured environments, operate in confined spaces, and interact with a diverse range of objects would be desirable for exploration and biomedical applications. The continued development of millirobots, however, requires simple and scalable fabrication techniques. Here, we propose a minimalist approach to construct millirobots by coating inanimate objects with a composited agglutinate magnetic spray. Our approach enables a variety of one-dimensional (1D), 2D, or 3D objects to be covered with a thin magnetically drivable film (~100 to 250 micrometers in thickness). The film is thin enough to preserve the original size, morphology, and structure of the objects while providing actuation of up to hundreds of times its own weight. Under the actuation of a magnetic field, our millirobots are able to demonstrate a range of locomotive abilities: crawling, walking, and rolling. Moreover, we can reprogram and disintegrate the magnetic film on our millirobots on demand. We leverage these abilities to demonstrate biomedical applications, including catheter navigation and drug delivery.

Fully integrated battery-free and flexible electrochemical tag for on-demand wireless in situ monitoring of heavy metals

2020 ◽  
Vol 310 ◽  
pp. 127809 ◽  
Author(s):  
Gang Xu ◽  
Xin Li ◽  
Chen Cheng ◽  
Jie Yang ◽  
Zhaoyang Liu ◽  
...  
Keyword(s):  
Heavy Metals ◽  
In Situ Monitoring ◽  
Fully Integrated ◽  
On Demand

ATP triggered drug release and DNA co-delivery systems based on ATP responsive aptamers and polyethylenimine complexes

2016 ◽  
Vol 4 (21) ◽  
pp. 3832-3841 ◽  
Author(s):  
Guan-Hai Wang ◽  
Guo-Liang Huang ◽  
Yi Zhao ◽  
Xing-Xiang Pu ◽  
Tong Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Anticancer Drug ◽  
Delivery Systems ◽  
On Demand ◽  
Triggered Drug Release

An ATP-responsive nanocarrier based on PEI and aptamers complexes was designed for anticancer drug and DNA co-delivery. The nanocarrier displayed on-demand drug release and effective gene capability.

scholarly journals Advances in Anticancer Drug Discovery

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1821
Author(s):  
Jóhannes Reynisson
Keyword(s):  
Heavy Metals ◽  
Drug Discovery ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Guest Editor ◽  
Biological Processes ◽  
Special Issue ◽  
Research Papers ◽  
Anticancer Drug Discovery ◽  
Chemical Matter

It has been an absolute pleasure to be the guest editor of this Special Issue! As the title indicates, the topic is on the advances made against cancer. Sixteen manuscripts were published, including eleven research papers and five reviews. The depth and width of the research presented is truly impressive, i.e., the detail of the biological processes within the cancer cells that are elucidated and the diverse nature of the chemical matter under investigation, spanning from heavy metals to small organic [...]

Sampling and analysis of the air-water interface with SEM and EDS of microlayers

1989 ◽  
Vol 47 ◽  
pp. 1004-1005
Author(s):  
Randall W. Smith ◽  
John Dash
Keyword(s):  
Heavy Metals ◽  
Surface Microlayer ◽  
Surface Films ◽  
Water Interface ◽  
Physical Processes ◽  
Infrared Spectroscopic Analysis ◽  
Eds Analysis ◽  
Air Water Interface ◽  
Significant Area ◽  
Bulk Chemical

The structure of the air-water interface forms a boundary layer that involves biological ,chemical geological and physical processes in its formation. Freshwater and sea surface microlayers form at the air-water interface and include a diverse assemblage of organic matter, detritus, microorganisms, plankton and heavy metals. The sampling of microlayers and the examination of components is presently a significant area of study because of the input of anthropogenic materials and their accumulation at the air-water interface. The neustonic organisms present in this environment may be sensitive to the toxic components of these inputs. Hardy reports that over 20 different methods have been developed for sampling of microlayers, primarily for bulk chemical analysis. We report here the examination of microlayer films for the documentation of structure and composition.Baier and Gucinski reported the use of Langmuir-Blogett films obtained on germanium prisms for infrared spectroscopic analysis (IR-ATR) of components. The sampling of microlayers has been done by collecting fi1ms on glass plates and teflon drums, We found that microlayers could be collected on 11 mm glass cover slips by pulling a Langmuir-Blogett film from a surface microlayer. Comparative collections were made on methylcel1ulose filter pads. The films could be air-dried or preserved in Lugol's Iodine Several slicks or surface films were sampled in September, 1987 in Chesapeake Bay, Maryland and in August, 1988 in Sequim Bay, Washington, For glass coverslips the films were air-dried, mounted on SEM pegs, ringed with colloidal silver, and sputter coated with Au-Pd, The Langmuir-Blogett film technique maintained the structure of the microlayer intact for examination, SEM observation and EDS analysis were then used to determine organisms and relative concentrations of heavy metals, using a Link AN 10000 EDS system with an ISI SS40 SEM unit. Typical heavy microlayer films are shown in Figure 3.

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