ATP triggered drug release and DNA co-delivery systems based on ATP responsive aptamers and polyethylenimine complexes

2016 ◽  
Vol 4 (21) ◽  
pp. 3832-3841 ◽  
Author(s):  
Guan-Hai Wang ◽  
Guo-Liang Huang ◽  
Yi Zhao ◽  
Xing-Xiang Pu ◽  
Tong Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Anticancer Drug ◽  
Delivery Systems ◽  
On Demand ◽  
Triggered Drug Release

An ATP-responsive nanocarrier based on PEI and aptamers complexes was designed for anticancer drug and DNA co-delivery. The nanocarrier displayed on-demand drug release and effective gene capability.

Smart pH/Redox Dual-Responsive Nanogels for On-Demand Intracellular Anticancer Drug Release

2016 ◽  
Vol 8 (12) ◽  
pp. 7729-7738 ◽  
Author(s):  
Hao Yang ◽  
Qin Wang ◽  
Shan Huang ◽  
Ai Xiao ◽  
Fuying Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Anticancer Drug ◽  
On Demand ◽  
Dual Responsive

Biotin-guided anticancer drug delivery with acidity-triggered drug release

2015 ◽  
Vol 51 (45) ◽  
pp. 9343-9345 ◽  
Author(s):  
Soyeon Park ◽  
Eunjin Kim ◽  
Won Young Kim ◽  
Chulhun Kang ◽  
Jong Seung Kim
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Anticancer Drug Delivery ◽  
Triggered Drug Release

A novel biotin-guided anticancer drug delivery system, prodrug 9, consisting of biotin, nitrobenzene, and doxorubicin, with acid-triggered drug releasing capability was synthesized.

scholarly journals Stimuli-Responsive Nanofibers Containing Gold Nanorods for On-Demand Drug Delivery Platforms

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1319
Author(s):  
Baljinder Singh ◽  
Nutan Shukla ◽  
Junkee Kim ◽  
Kibeom Kim ◽  
Myoung-Hwan Park
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Gold Nanorods ◽  
Drug Delivery Systems ◽  
Near Infrared ◽  
Resonance Effect ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
On Demand ◽  
Multiple Drugs

On-demand drug delivery systems using nanofibers have attracted significant attention owing to their controllable properties for drug release through external stimuli. Near-infrared (NIR)-responsive nanofibers provide a platform where the drug release profile can be achieved by the on-demand supply of drugs at a desired dose for cancer therapy. Nanomaterials such as gold nanorods (GNRs) exhibit absorbance in the NIR range, and in response to NIR irradiation, they generate heat as a result of a plasmon resonance effect. In this study, we designed poly (N-isopropylacrylamide) (PNIPAM) composite nanofibers containing GNRs. PNIPAM is a heat-reactive polymer that provides a swelling and deswelling property to the nanofibers. Electrospun nanofibers have a large surface-area-to-volume ratio, which is used to effectively deliver large quantities of drugs. In this platform, both hydrophilic and hydrophobic drugs can be introduced and manipulated. On-demand drug delivery systems were obtained through stimuli-responsive nanofibers containing GNRs and PNIPAM. Upon NIR irradiation, the heat generated by the GNRs ensures shrinking of the nanofibers owing to the thermal response of PNIPAM, thereby resulting in a controlled drug release. The versatility of the light-responsive nanofibers as a drug delivery platform was confirmed in cell studies, indicating the advantages of the swelling and deswelling property of the nanofibers and on–off drug release behavior with good biocompatibility. In addition, the system has potential for the combination of chemotherapy with multiple drugs to enhance the effectiveness of complex cancer treatments.

Hypoxia- and singlet oxygen-responsive chemo-photodynamic Micelles featured with glutathione depletion and aldehyde production

2019 ◽  
Vol 7 (1) ◽  
pp. 429-441 ◽  
Author(s):  
Jian Deng ◽  
Fang Liu ◽  
Lina Wang ◽  
Yang An ◽  
Min Gao ◽  
...  
Keyword(s):  
Drug Release ◽  
Singlet Oxygen ◽  
Glutathione Depletion ◽  
Efficient Approach ◽  
On Demand ◽  
Triggered Drug Release ◽  
Drug Liberation

Triggered drug release from anti-tumor nanomedicine is an efficient approach to address the dilemma of systemic nanocarrier stability and on-demand drug liberation in tumor sites.

Poly(N-isopropylacrylamide) derived nanogels demonstrated thermosensitive self-assembly and GSH-triggered drug release for efficient tumor Therapy

2019 ◽  
Vol 10 (29) ◽  
pp. 4031-4041 ◽  
Author(s):  
Jiaojiao Chen ◽  
Ming Wu ◽  
Hanitrarimalala Veroniaina ◽  
Subhankar Mukhopadhyay ◽  
Juequan Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Tumor Therapy ◽  
Delivery Systems ◽  
Core Shell ◽  
Stimuli Responsive ◽  
Triggered Drug Release

Recently, interest in stimuli-responsive core–shell nanogels as drug delivery systems for tumor therapy has increased.

scholarly journals Injectable nanoengineered stimuli-responsive hydrogels for on-demand and localized therapeutic delivery

Nanoscale ◽  
2017 ◽  
Vol 9 (40) ◽  
pp. 15379-15389 ◽  
Author(s):  
Nima A. Jalili ◽  
Manish K. Jaiswal ◽  
Charles W. Peak ◽  
Lauren M. Cross ◽  
Akhilesh K. Gaharwar
Keyword(s):  
Drug Release ◽  
Stimuli Responsive ◽  
Nanocomposite Hydrogels ◽  
Therapeutic Delivery ◽  
On Demand ◽  
Triggered Drug Release ◽  
Responsive Hydrogels

Injectable nanocomposite hydrogels for temperature triggered drug release.

Comb-like poly(l-cysteine) derivatives with different side groups: synthesis via photochemistry and click chemistry, multi-responsive nanostructures, triggered drug release and cytotoxicity

2015 ◽  
Vol 6 (38) ◽  
pp. 6857-6869 ◽  
Author(s):  
Xingjie Wu ◽  
Linzhu Zhou ◽  
Yue Su ◽  
Chang-Ming Dong
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Click Chemistry ◽  
On Demand ◽  
Triggered Drug Release ◽  
Ene Addition

A series of comb-like graft polypeptides having different side groups and tunable grafting ratios were prepared by sequential photocleavage reactions and Michael-type thiol–ene addition, which provides a promising platform for on-demand nanomedicine and cancer therapy.

scholarly journals Remote Temperature-Responsive Parafilm Dermal Patch for On-Demand Topical Drug Delivery

Micromachines ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 975
Author(s):  
Shahrukh Zaman Akash ◽  
Farjana Yesmin Lucky ◽  
Murad Hossain ◽  
Asim Kumar Bepari ◽  
G. M. Sayedur Rahman ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Burst Release ◽  
Therapeutic Effects ◽  
Microbial Infection ◽  
Temperature Responsive ◽  
On Demand

The development of externally controlled drug delivery systems that can rapidly trigger drug release is widely expected to change the landscape of future drug carriers. In this study, a drug delivery system was developed for on-demand therapeutic effects. The thermoresponsive paraffin film can be loaded on the basis of therapeutic need, including local anesthetic (lidocaine) or topical antibiotic (neomycin), controlled remotely by a portable mini-heater. The application of mild temperature (45 °C) to the drug-loaded paraffin film allowed a rapid stimulus response within a short time (5 min). This system exploits regular drug release and the rapid generation of mild heat to trigger a burst release of 80% within 6 h of any locally administered drug. The in vitro drug release studies and in vivo therapeutic activity were observed for local anesthesia and wound healing using a neomycin-loaded film. The studies demonstrated on-demand drug release with minimized inflammation and microbial infection. This temperature-responsive drug-loaded film can be triggered remotely to provide flexible control of dose magnitude and timing. Our preclinical studies on these remotely adjustable drug delivery systems can significantly improve patient compliance and medical practice.

Near-Infrared Light-Responsive Nanogels with Diselenide-Cross-Linkers for On-Demand Degradation and Triggered Drug Release

2015 ◽  
Vol 32 (5) ◽  
pp. 547-551 ◽  
Author(s):  
Yefei Tian ◽  
Jin Zheng ◽  
Xiaoling Tang ◽  
Qingguang Ren ◽  
Yajun Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
On Demand ◽  
Triggered Drug Release
Sign in / Sign up

Export Citation Format

Share Document