Nitric oxide-releasing injectable hydrogels with high antibacterial activity through in situ formation of peroxynitrite

2018 ◽  
Vol 67 ◽  
pp. 66-78 ◽  
Author(s):  
Thai Thanh Hoang Thi ◽  
Yunki Lee ◽  
Phuong Le Thi ◽  
Ki Dong Park
Keyword(s):  
Nitric Oxide ◽  
Antibacterial Activity ◽  
Injectable Hydrogels ◽  
High Antibacterial Activity ◽  
In Situ Formation ◽  
Nitric Oxide Releasing

Chitosan chemically modified to deliver nitric oxide with high antibacterial activity

Nitric Oxide ◽  
2021 ◽  
Vol 106 ◽  
pp. 24-34
Author(s):  
Milena T. Pelegrino ◽  
Joana C. Pieretti ◽  
Gerson Nakazato ◽  
Marcelly Chue Gonçalves ◽  
José Carlos Moreira ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Antibacterial Activity ◽  
Chemically Modified ◽  
High Antibacterial Activity

Injectable cationic hydrogels with high antibacterial activity and low toxicity

2016 ◽  
Vol 7 (36) ◽  
pp. 5620-5624 ◽  
Author(s):  
Hong Du ◽  
Ying Wang ◽  
Xuxia Yao ◽  
Qiaojie Luo ◽  
Weipu Zhu ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Ethylene Glycol ◽  
Click Reaction ◽  
Physiological Conditions ◽  
High Antibacterial Activity ◽  
Low Toxicity ◽  
Cationic Hydrogels

We prepared injectable cationic hydrogels with strong antibacterial activity and remarkably low toxicity by in situ thiol–ene “click” reaction between dimethacrylate terminated poly(hexamethylene guanidine) (PHMGDMA) and poly[oligo(ethylene) glycol mercaptosuccinate] (POEGMS) under physiological conditions.

In Situ Sensing of DNA Damage by a Nitric Oxide‐Releasing Compound

2005 ◽  
Vol 38 (15) ◽  
pp. 2525-2540 ◽  
Author(s):  
Victor C. Diculescu ◽  
Rui M. Barbosa ◽  
Ana Maria Oliveira Brett
Keyword(s):  
Nitric Oxide ◽  
Dna Damage ◽  
In Situ Sensing ◽  
Nitric Oxide Releasing

scholarly journals Antibacterial Activity of Nitric Oxide-Releasing Hyperbranched Polyamidoamines

2017 ◽  
Vol 29 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Lei Yang ◽  
Xingzhi Wang ◽  
Dakota J. Suchyta ◽  
Mark H. Schoenfisch
Keyword(s):  
Nitric Oxide ◽  
Antibacterial Activity ◽  
Nitric Oxide Releasing

scholarly journals Antibacterial activity of nitric oxide releasing silver nanoparticles

2017 ◽  
Vol 838 ◽  
pp. 012031 ◽  
Author(s):  
Amedea B. Seabra ◽  
Nixson Manosalva ◽  
Bruna de Araujo Lima ◽  
Milena T. Pelegrino ◽  
Marcelo Brocchi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Nitric Oxide Releasing

scholarly journals Nitric Oxide-Releasing Thermoresponsive Pluronic F127/Alginate Hydrogel for Enhanced Antibacterial Activity and Accelerated Healing of Infected Wounds

Pharmaceutics ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 926
Author(s):  
Jiafu Cao ◽  
Mingzhi Su ◽  
Nurhasni Hasan ◽  
Juho Lee ◽  
Dongmin Kwak ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Antibacterial Activity ◽  
Multidrug Resistant ◽  
Pluronic F127 ◽  
Scanning Calorimetry ◽  
No Release ◽  
Infected Wounds ◽  
Nitric Oxide Releasing

Nitric oxide (NO), a highly reactive and lipophilic molecule, is one of the molecules present in the wound environment and implicated as an important regulator in all phases of wound healing. Here, we developed an NO-releasing thermoresponsive hydrogel (GSNO-PL/AL) composed of S-nitrosoglutathione (GSNO), pluronic F127 (PL), and alginate (AL) for the treatment of infected wounds. The GSNO was incorporated into the thermoresponsive PL/AL hydrogel, and differential scanning calorimetry techniques were used for the hydrogel characterization. The hydrogel was assessed by in vitro NO release, antibacterial activity, cytotoxicity, and wound-healing activity. The GSNO-PL/AL hydrogel demonstrated thermal responsiveness and biocompatibility, and it showed sustained NO release for 7 days. It also exhibited potent bactericidal activity against Gram-positive methicillin-resistant Staphylococcus aureus and Gram-negative multidrug-resistant Pseudomonas aeruginosa (MRPA). Moreover, the GSNO-PL/AL treatment of MRPA-infected wounds accelerated healing with a reduced bacterial burden in the wounds. The GSNO-PL/AL hydrogel would be a promising option for the treatment of infected wounds.

In situ formation of injectable hydrogels for chronic wound healing

2020 ◽  
Vol 8 (38) ◽  
pp. 8768-8780
Author(s):  
Yunfen Gao ◽  
Zhen Li ◽  
Jun Huang ◽  
Meng Zhao ◽  
Jun Wu
Keyword(s):  
Wound Healing ◽  
Chronic Wound ◽  
Injectable Hydrogels ◽  
The Past ◽  
In Situ Formation

Hydrogels have been widely used in wound healing treatment over the past decade.

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