In situ formation of injectable hydrogels for chronic wound healing

2020 ◽  
Vol 8 (38) ◽  
pp. 8768-8780
Author(s):  
Yunfen Gao ◽  
Zhen Li ◽  
Jun Huang ◽  
Meng Zhao ◽  
Jun Wu
Keyword(s):  
Wound Healing ◽  
Chronic Wound ◽  
Injectable Hydrogels ◽  
The Past ◽  
In Situ Formation

Hydrogels have been widely used in wound healing treatment over the past decade.

Impurity-controlled contrast in secondary-electron images of reaction-bonded silicon carbide

1990 ◽  
Vol 48 (4) ◽  
pp. 888-889
Author(s):  
R.A. Youngman
Keyword(s):  
Secondary Electron ◽  
Microstructural Characterization ◽  
Optical Microscope ◽  
The Past ◽  
Contrast Mechanism ◽  
Backscattered Electron ◽  
In Situ Formation ◽  
Secondary Ion

Reaction-bonded SiC is formed by the high temperature (>2100°C) heat treatment of a mixture of alpha-SiC powder and organic binders in the presence of elemental Si. The bonding occurs by the in-situ formation of beta-SiC from the reaction of the pyrolyzed binder and the Si. Substantial microstructural characterization of these materials has been carried out in the past. A particular feature of these analyses is the so-called trace-impurity-controlled contrast of secondary electron (SE) images of uncoated specimens. This report describes further attempts to elucidate the origin of this contrast mechanism.Samples of reaction-bonded SiC (Hexoloy KT, The Carborundum Co.) were prepared for multiple-technique analysis. This was accomplished by preparing an optical thin section for reflected and transmitted optical microscopy. Regions of interest were diamond-scribed on the optical microscope (Leitz, Orthoplan) and then SE and backscattered electron (BE) microscopy (CamScan, Series IV) of the same areas (both coated and uncoated with evaporated carbon) was conducted. Finally, the same areas were imaged in a secondary ion mass spectrometer (SIMS) (Cameca, IMS3F) to detect trace and major impurity levels.

Evaluation of in situ injectable hydrogels as controlled release device for ANXA1 derived peptide in wound healing

2015 ◽  
Vol 115 ◽  
pp. 629-635 ◽  
Author(s):  
Pasquale Del Gaudio ◽  
Felicetta De Cicco ◽  
Rita P. Aquino ◽  
Patrizia Picerno ◽  
Paola Russo ◽  
...  
Keyword(s):  
Wound Healing ◽  
Controlled Release ◽  
Injectable Hydrogels ◽  
Release Device

The Use of Advanced Analytical Techniques for Characterization of the Chemical, Physical, and Crystallographic Nature of a Surface

1973 ◽  
Vol 31 ◽  
pp. 132-133 ◽  
Author(s):  
R. E. Herfert
Keyword(s):  
Surface Characterization ◽  
Analytical Techniques ◽  
X Ray Diffraction ◽  
Depth Of Penetration ◽  
X Ray ◽  
The Past ◽  
Transmission Electron ◽  
Scanning Electron

Studies of the nature of a surface, either metallic or nonmetallic, in the past, have been limited to the instrumentation available for these measurements. In the past, optical microscopy, replica transmission electron microscopy, electron or X-ray diffraction and optical or X-ray spectroscopy have provided the means of surface characterization. Actually, some of these techniques are not purely surface; the depth of penetration may be a few thousands of an inch. Within the last five years, instrumentation has been made available which now makes it practical for use to study the outer few 100A of layers and characterize it completely from a chemical, physical, and crystallographic standpoint. The scanning electron microscope (SEM) provides a means of viewing the surface of a material in situ to magnifications as high as 250,000X.

In situ microprobe quantitation of inorganic particle burden in paraffin sections of lung tissue

1988 ◽  
Vol 46 ◽  
pp. 990-991
Author(s):  
Jerrold L. Abraham
Keyword(s):  
Lung Tissue ◽  
Quantitative Information ◽  
Particulate Material ◽  
Paraffin Sections ◽  
Tissue Samples ◽  
Qualitative And Quantitative ◽  
The Past ◽  
Quantitative Analyses ◽  
Data Result

Inorganic particulate material of diverse types is present in the ambient and occupational environment, and exposure to such materials is a well recognized cause of some lung disease. To investigate the interaction of inhaled inorganic particulates with the lung it is necessary to obtain quantitative information on the particulate burden of lung tissue in a wide variety of situations. The vast majority of diagnostic and experimental tissue samples (biopsies and autopsies) are fixed with formaldehyde solutions, dehydrated with organic solvents and embedded in paraffin wax. Over the past 16 years, I have attempted to obtain maximal analytical use of such tissue with minimal preparative steps. Unique diagnostic and research data result from both qualitative and quantitative analyses of sections. Most of the data has been related to inhaled inorganic particulates in lungs, but the basic methods are applicable to any tissues. The preparations are primarily designed for SEM use, but they are stable for storage and transport to other laboratories and several other instruments (e.g., for SIMS techniques).

An atomic-resolution microscope study of Al contracts on GaAs

1986 ◽  
Vol 44 ◽  
pp. 726-727
Author(s):  
Z. Liliental-Weber ◽  
C. Nelson ◽  
R. Ludeke ◽  
R. Gronsky ◽  
J. Washburn
Keyword(s):  
High Speed ◽  
Schottky Contacts ◽  
Detailed Knowledge ◽  
The Past ◽  
Semiconductor Interfaces ◽  
Deposited Metal ◽  
Microwave Applications ◽  
Free Interfaces ◽  
Potential Use

The properties of metal/semiconductor interfaces have received considerable attention over the past few years, and the Al/GaAs system is of special interest because of its potential use in high-speed logic integrated optics, and microwave applications. For such materials a detailed knowledge of the geometric and electronic structure of the interface is fundamental to an understanding of the electrical properties of the contact. It is well known that the properties of Schottky contacts are established within a few atomic layers of the deposited metal. Therefore surface contamination can play a significant role. A method for fabricating contamination-free interfaces is absolutely necessary for reproducible properties, and molecularbeam epitaxy (MBE) offers such advantages for in-situ metal deposition under UHV conditions

scholarly journals Formation of compact systems of super-Earths via dynamical instabilities and giant impacts

2019 ◽  
Vol 491 (4) ◽  
pp. 5595-5620 ◽  
Author(s):  
Sanson T S Poon ◽  
Richard P Nelson ◽  
Seth A Jacobson ◽  
Alessandro Morbidelli
Keyword(s):  
Initial Conditions ◽  
Post Processing ◽  
Significant Modification ◽  
Kepler Mission ◽  
Giant Impacts ◽  
Low Mass ◽  
In Situ Formation ◽  
Dynamical Instabilities ◽  
Gaseous Envelopes

ABSTRACT The NASA’s Kepler mission discovered ∼700 planets in multiplanet systems containing three or more transiting bodies, many of which are super-Earths and mini-Neptunes in compact configurations. Using N-body simulations, we examine the in situ, final stage assembly of multiplanet systems via the collisional accretion of protoplanets. Our initial conditions are constructed using a subset of the Kepler five-planet systems as templates. Two different prescriptions for treating planetary collisions are adopted. The simulations address numerous questions: Do the results depend on the accretion prescription?; do the resulting systems resemble the Kepler systems, and do they reproduce the observed distribution of planetary multiplicities when synthetically observed?; do collisions lead to significant modification of protoplanet compositions, or to stripping of gaseous envelopes?; do the eccentricity distributions agree with those inferred for the Kepler planets? We find that the accretion prescription is unimportant in determining the outcomes. The final planetary systems look broadly similar to the Kepler templates adopted, but the observed distributions of planetary multiplicities or eccentricities are not reproduced, because scattering does not excite the systems sufficiently. In addition, we find that ∼1 per cent of our final systems contain a co-orbital planet pair in horseshoe or tadpole orbits. Post-processing the collision outcomes suggests that they would not significantly change the ice fractions of initially ice-rich protoplanets, but significant stripping of gaseous envelopes appears likely. Hence, it may be difficult to reconcile the observation that many low-mass Kepler planets have H/He envelopes with an in situ formation scenario that involves giant impacts after dispersal of the gas disc.

scholarly journals Method for determining the thermal conductivity of in situ formation rock using drilling cuttings

AIP Advances ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 065015
Author(s):  
Fu Yi ◽  
Xupeng Qi ◽  
Xuexin Zheng ◽  
Huize Yu ◽  
Wenming Bai ◽  
...  
Keyword(s):  
Thermal Conductivity ◽  
In Situ Formation
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