Injectable cationic hydrogels with high antibacterial activity and low toxicity

2016 ◽  
Vol 7 (36) ◽  
pp. 5620-5624 ◽  
Author(s):  
Hong Du ◽  
Ying Wang ◽  
Xuxia Yao ◽  
Qiaojie Luo ◽  
Weipu Zhu ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Ethylene Glycol ◽  
Click Reaction ◽  
Physiological Conditions ◽  
High Antibacterial Activity ◽  
Low Toxicity ◽  
Cationic Hydrogels

We prepared injectable cationic hydrogels with strong antibacterial activity and remarkably low toxicity by in situ thiol–ene “click” reaction between dimethacrylate terminated poly(hexamethylene guanidine) (PHMGDMA) and poly[oligo(ethylene) glycol mercaptosuccinate] (POEGMS) under physiological conditions.

Fully biodegradable antibacterial hydrogels via thiol–ene “click” chemistry

2014 ◽  
Vol 5 (13) ◽  
pp. 4002-4008 ◽  
Author(s):  
Hong Du ◽  
Guangyu Zha ◽  
Lilong Gao ◽  
Huan Wang ◽  
Xiaodong Li ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Click Chemistry ◽  
Click Reaction ◽  
Poly Ethylene Glycol ◽  
Physiological Conditions ◽  
Poly Ethylene

Novel biodegradable antimicrobial hydrogels, which are promising for use as biomaterials, were prepared facilely via a thiol–ene “click” reaction under human physiological conditions using multifunctional poly(ethylene glycol) (PEG) derivatives as precursors.

scholarly journals In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering

2014 ◽  
Vol 2 (2) ◽  
pp. 167-175 ◽  
Author(s):  
Vinh X. Truong ◽  
Matthew P. Ablett ◽  
Hamish T. J. Gilbert ◽  
James Bowen ◽  
Stephen M. Richardson ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Ethylene Glycol ◽  
Click Reaction ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene

High antibacterial activity and low toxicity of pyridoxal derivatives of chitosan and their nanoparticles

2021 ◽  
Vol 31 (4) ◽  
pp. 504-506
Author(s):  
Andreii S. Kritchenkov ◽  
Margarita N. Kurasova ◽  
Anastasia A. Godzishevskaya ◽  
Elizaveta S. Mitrofanova ◽  
Anton R. Egorov ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
High Antibacterial Activity ◽  
Low Toxicity ◽  
Derivatives Of

Antibacterial Titanium Plate Anodized by being Discharged in NaCl Solution Exhibits Cell Compatibility

2004 ◽  
Vol 83 (2) ◽  
pp. 115-119 ◽  
Author(s):  
Y. Shibata ◽  
H. Kawai ◽  
H. Yamamoto ◽  
T. Igarashi ◽  
T. Miyazaki
Keyword(s):  
Antibacterial Activity ◽  
Pure Titanium ◽  
The Other ◽  
Nacl Solution ◽  
Titanium Plate ◽  
Cell Extension ◽  
Cell Compatibility ◽  
High Antibacterial Activity ◽  
Surface Enhanced ◽  
Low Toxicity

Implant surfaces should be modified to achieve excellent cell compatibility as well as antibacterial activity. Our previous study demonstrated that titanium plates anodized by being discharged in NaCl (Ti-Cl) exhibited high antibacterial activity. Since Ti-Cl was prepared with a NaCl solution, we hypothesized that Ti-Cl would exhibit low toxicity toward cells. The aims of this study were to characterize the surface of Ti-Cl and investigate the cell compatibility (MC3T3-E1 and L929 cells) of Ti-Cl. The results demonstrated that, since the TiCl3 formed on the Ti-Cl surface was hydrolyzed into HCl, HClO, and TiOH after immersion in pure distilled water, TiCl3 contributed to the antibacterial activity of Ti-Cl. On the other hand, TiO formed on the Ti-Cl surface enhanced cell extension and cell growth through a larger adsorption of fibronectin compared with the pure titanium control. These findings suggest that antibacterial titanium is a promising material for use in dental implant systems.

Phytochemical Evaluation and Screening of Cardiotonic, Antibacterial and Anthelmintic Activities of Sida cordifolia L.

2014 ◽  
Vol 7 (3) ◽  
pp. 2567-2573
Author(s):  
Sarella Prakash Nathaniel Kumar ◽  
Kanthal L.K. ◽  
Durga S ◽  
Achutha Rama Raju D ◽  
Satyavati K
Keyword(s):  
Antibacterial Activity ◽  
Rural Areas ◽  
Anthelmintic Activity ◽  
Diffusion Method ◽  
Frog Heart ◽  
Aqueous Extracts ◽  
Cardiotonic Activity ◽  
Herbal Products ◽  
High Antibacterial Activity ◽  
Sida Cordifolia

Several herbs are traditionally used in the treatment of a variety of ailments particularly in the rural areas, where herbal medicine is mainly the source of health care system. Many of these herbs havenot been assessed for safety or toxicity to tissue or organs of the mammalian recipients. An attempt is made to prove the efficacy of Sida cordifolia Linn., (a traditional medicinal plant chosen on the basis of ethnomedical knowledge) for its Cardiotonic, Antibacterial and Anthelmintic activities. Sida cordofolia Linn., is used traditionally, inter alia, in the treatment of various infections, asthma, diarrhoea, heart and stomach disorders. Cardiotonicactivity is performed using isolated Frog Heart Perfusion Technique. Antibacterial activity of the whole plant extracts were assessed by Agar well diffusion method against the strains of Bacillus subtilis, Escherichia coli, and Staphylococcus aureus. Anthelmintic activity was studied against Pheretima posthuma. Phytochemical screening of powdered plant material revealed thepresence of some secondary metabolites such as alkaloids, saponins, tannins, glycosides and flavonoids. Results indicated that methanol, chloroform, aqueous extracts have significant cardiotonic activity but less than standard drugs. Methanol and Aqueous extracts showed high antibacterial activity and anthelmintic activity than the standard drugs. In a nutshell, we can conclude that the methanol and aqueous fractions of Sida cordifolia Linn., had a profound antibacterial and anthelmintic effect eventhough it possessed very significant cardiotonic activity. This validates its continuous usage in ethnomedicine. This plant could be developed into cheap, safe and culturally acceptable standardized herbal products and may serve as asource of new molecules for broad-spectrum antimicrobial and anthelmintic agent.

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

Bicomponent multifilament yarns of recycled poly(ethylene terephthalate) and nano-titanium dioxide for antibacterial carpet

2021 ◽  
pp. 152808372110117
Author(s):  
Sommai Pivsa-Art ◽  
Komson Sunyikhan ◽  
Weraporn Pivsa-Art
Keyword(s):  
Antibacterial Activity ◽  
Titanium Dioxide ◽  
Ethylene Terephthalate ◽  
Antibacterial Properties ◽  
Nano Structure ◽  
Elongation At Break ◽  
High Antibacterial Activity ◽  
Poly Ethylene Terephthalate ◽  
Poly Ethylene ◽  
Multifilament Yarns

Recycled poly(ethylene terephthalate) (RPET) multifilament yarns are used in carpet manufacturing as a way to reduce plastic waste. The conventional RPET carpet is however susceptible to bacterial accumulation. As a result, this research experimentally doped RPET with nano-structure titanium dioxide (nano-TiO2) to produce RPET/nano-TiO2 bicomponent multifilament yarns with antibacterial property. The experimental multifilament yarn structure consisted of two parts: neat RPET core and RPET/nano-TiO2 shell. The nano-TiO2 content in the shell was varied between 1 and 3 wt% and the core/shell (C/S) ratios between 90/10, 70/30, and 50/50 w/w. The effects of C/S ratio and nano-TiO2 content on the mechanical and antibacterial properties of bicomponent multifilament yarns were determined. The experimental results indicated that the C/S ratio had no effect on the tenacity and elongation at break. Meanwhile, the tenacity and elongation at break of bicomponent fibers increased with nano-TiO2 content in the shell. The TiO2-doped RPET bicomponent yarns effectively inhibited the growth of Escherichia coli and Staphylococcus aureus. The 90/10 bicomponent multifilament fiber with 3 wt% TiO2 achieved the highest antibacterial activity. The very high antibacterial activity was attributable to greater deposition of nano-TiO2 particles near and on the shell surface.

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