Enzyme-Activated Nitric Oxide-Releasing Composite Material for Antibacterial Activity Against Escherichia coli

2020 ◽  
Vol 3 (8) ◽  
pp. 5367-5374
Author(s):  
Hailey A. J. Hibbard ◽  
Melissa M. Reynolds
Keyword(s):  
Nitric Oxide ◽  
Escherichia Coli ◽  
Antibacterial Activity ◽  
Composite Material ◽  
Nitric Oxide Releasing

Evaluation of antibacterial activity of nitric oxide-releasing polymeric particles against Staphylococcus aureus and Escherichia coli from bovine mastitis

2014 ◽  
Vol 473 (1-2) ◽  
pp. 20-29 ◽  
Author(s):  
Viviane F. Cardozo ◽  
Cesar A.C. Lancheros ◽  
Adélia M. Narciso ◽  
Elaine C.S. Valereto ◽  
Renata K.T. Kobayashi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Bovine Mastitis ◽  
Polymeric Particles ◽  
Nitric Oxide Releasing

scholarly journals Antibacterial Activity of Nitric Oxide-Releasing Hyperbranched Polyamidoamines

2017 ◽  
Vol 29 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Lei Yang ◽  
Xingzhi Wang ◽  
Dakota J. Suchyta ◽  
Mark H. Schoenfisch
Keyword(s):  
Nitric Oxide ◽  
Antibacterial Activity ◽  
Nitric Oxide Releasing

scholarly journals Antibacterial activity of nitric oxide releasing silver nanoparticles

2017 ◽  
Vol 838 ◽  
pp. 012031 ◽  
Author(s):  
Amedea B. Seabra ◽  
Nixson Manosalva ◽  
Bruna de Araujo Lima ◽  
Milena T. Pelegrino ◽  
Marcelo Brocchi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Nitric Oxide Releasing

scholarly journals Nitric Oxide-Releasing Thermoresponsive Pluronic F127/Alginate Hydrogel for Enhanced Antibacterial Activity and Accelerated Healing of Infected Wounds

Pharmaceutics ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 926
Author(s):  
Jiafu Cao ◽  
Mingzhi Su ◽  
Nurhasni Hasan ◽  
Juho Lee ◽  
Dongmin Kwak ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Antibacterial Activity ◽  
Multidrug Resistant ◽  
Pluronic F127 ◽  
Scanning Calorimetry ◽  
No Release ◽  
Infected Wounds ◽  
Nitric Oxide Releasing

Nitric oxide (NO), a highly reactive and lipophilic molecule, is one of the molecules present in the wound environment and implicated as an important regulator in all phases of wound healing. Here, we developed an NO-releasing thermoresponsive hydrogel (GSNO-PL/AL) composed of S-nitrosoglutathione (GSNO), pluronic F127 (PL), and alginate (AL) for the treatment of infected wounds. The GSNO was incorporated into the thermoresponsive PL/AL hydrogel, and differential scanning calorimetry techniques were used for the hydrogel characterization. The hydrogel was assessed by in vitro NO release, antibacterial activity, cytotoxicity, and wound-healing activity. The GSNO-PL/AL hydrogel demonstrated thermal responsiveness and biocompatibility, and it showed sustained NO release for 7 days. It also exhibited potent bactericidal activity against Gram-positive methicillin-resistant Staphylococcus aureus and Gram-negative multidrug-resistant Pseudomonas aeruginosa (MRPA). Moreover, the GSNO-PL/AL treatment of MRPA-infected wounds accelerated healing with a reduced bacterial burden in the wounds. The GSNO-PL/AL hydrogel would be a promising option for the treatment of infected wounds.

Chemical Composition and Antibacterial Activity of Essential Oils of Three Medicinal Plants from Algerian Semi-Arid Climatic Zone

2018 ◽  
Vol 16 (S1) ◽  
pp. S155-S163 ◽  
Author(s):  
S. Mehalaine ◽  
O. Belfadel ◽  
T. Menasria ◽  
A. Messaili
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Rosmarinus Officinalis ◽  
Salvia Officinalis ◽  
Thymus Algeriensis

The present study was carried out to determine, for the first time, the chemical composition and antibacterial activity of essential oils derived from the aerial parts of three aromatic plants Thymus algeriensis Boiss & Reut, Rosmarinus officinalis L., and Salvia officinalis L. growing under semiarid conditions. The essential oils were chemically analyzed and identified by gas chromatography (GC) and GC/ mass spectrometry (GC/MS) and their antimicrobial activity was individually evaluated against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa using both agar disk diffusion and agar dilution methods. The major constituents of Thymus algeriensis essential oil were identified as camphor (13.62%), 1,8-cineol (6.00%), borneol (5.74%), viridiflorol (4.00%), and linalool (3.93%). For Rosmarinus officinalis essential oil, 48 compounds were characterized, of which the main constituents were camphor (17.09%), Z-β-ocimene (10.88%), isoborneol (9.68%), α-bisabolol (7.89%), and borneol (5.11%). While, Salvia officinalis essential oil was characterized by β-thujone (16.44%), followed by viridiflorol (10.93%), camphor (8.99%), 1,8-cineol (8.11%), trans-caryophyllene (5.85%), and α-humulene (4.69%) as the major components. Notably, results from antibacterial screening indicated that Thymus algeriensis and Salvia officinalis essential oils exhibited a strong inhibitory effect against both Escherichia coli and Staphylococcus aureus compared to Rosmarinus officinalis essential oil. Further, less activity was recorded against Pseudomonas aeruginosa for the three tested essential oils.

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