Short adrenergic neurons innervating the female urethra of the cat

1971 ◽  
Vol 27 (3) ◽  
pp. 313-315 ◽  
Author(s):  
Ch. Owman ◽  
T. Owman ◽  
N. -O. Sjöberg
Keyword(s):  
Female Urethra ◽  
Adrenergic Neurons ◽  
Short Adrenergic Neurons

EFFECT OF HIGH DOSES OF OESTROGEN AND PROGESTERONE ON THE NORADRENALINE CONTENT OF THE SHORT ADRENERGIC NEURONS INNERVATING THE MALE GENITAL TRACT OF THE RAT

1970 ◽  
Vol 64 (3) ◽  
pp. 459-465 ◽  
Author(s):  
Ch. Owman ◽  
N.-O. Sjöberg ◽  
N. O. Sjöstrand ◽  
G. Swedin
Keyword(s):  
Genital Tract ◽  
Reproductive Tract ◽  
Female Genital Tract ◽  
Total Content ◽  
Prolonged Treatment ◽  
Noradrenaline Content ◽  
Adrenergic Neurons ◽  
Short Adrenergic Neurons ◽  
High Doses ◽  
Male Genital

ABSTRACT The effect of prolonged treatment with high doses of oestrogen and/or progesterone on the amount of adrenergic transmitter in the short adrenergic neurons of the male reproductive tract of castrated rats has been studied by chemical determinations and histochemical demonstration of noradrenaline. Oestrogen, progesterone, or a combination of both, had no overt effect on the total content or on the concentration of noradrenaline in the male genital organs. The results are discussed in the light of recent findings that the content of the noradrenaline transmitter in the short adrenergic neurons to the female genital tract is markedly influenced by these female sex hormones.

Effect of serotonin on brown adipose tissue and on its sympathetic neurons

1976 ◽  
Vol 231 (1) ◽  
pp. 34-39 ◽  
Author(s):  
G Steiner ◽  
S Evans
Keyword(s):  
Stromal Cells ◽  
Sympathetic Neurons ◽  
Metabolic Effect ◽  
Brown Fat ◽  
Fat Cells ◽  
Fat Pad ◽  
Adrenergic Neurons ◽  
Brown Adipose ◽  
Short Adrenergic Neurons ◽  
Metabolic Action

Previously we have shown that there are two types of sympathetic neurons in the rat interscapular brown fat-pad: long adrenergic neurons with cell bodies located in the paraspinal ganglia and short adrenergic neurons with cell bodies located within the pad itself. The present studies examine 1) the uptake of [3H]norepinephrine by these neurons, 2) the effect of serotonin on release of the catecholamine, and 3) the metabolic action of serotonin on brown fat. [3H]norepinephrine uptake from the medium in which brown fat slices are incubated is linear with time up to 90 min. This uptake is blocked by both cocaine and imipramine. As these drugs block uptake by sympathetic neurons, the [3H]norepinephrine is probably taken up by neurons and not by some other cell in the pad. Serotonin creatinine sulfate, but not creatinine sulfate, promotes the release of the catecholamine from these neurons. Serotonin also exerts a norepinephrine-like metabolic effect on slices of normal brown fat. It stimulates lipolysis and inhibits lipogenesis. Serotonin has no effect on isolated brown fat cells or on slices of reserpinized tissue. It also does not potentiate the action of norepinephrine on these last two preparations. Therefore serotonin's action on brown fat is mediated by norepinephrine-containing stromal cells. The data suggest that the rat brown fat-pad has sympathetic neurons that can take up norepinephrine and that serotonin exerts its metabolic effect by stimulating the release of norepinephrine from these neurons.

PERSISTING HIGH LEVEL OF TRANSMITTER IN UTERINE SHORT ADRENERGIC NEURONS FOLLOWING PROLONGED TREATMENT WITH 17β-OESTRADIOL

1969 ◽  
Vol 62 (1) ◽  
pp. 77-81 ◽  
Author(s):  
B. Falck ◽  
Ch. Owman ◽  
E. Rosengren ◽  
N.-O. Sjöberg
Keyword(s):  
Experimental Period ◽  
Sympathetic Chain ◽  
Prolonged Treatment ◽  
Adrenergic Nerve ◽  
Nerve Supply ◽  
Noradrenaline Content ◽  
Adrenergic Neurons ◽  
Short Adrenergic Neurons ◽  
High Level

ABSTRACT The myometrium of the rabbit uterus receives its adrenergic nerve supply by way of short adrenergic neurons originating in peripheral ganglia located at the uterovaginal junction. Treatment with 17β-oestradiol daily for 4 weeks produced a doubling of the total noradrenaline content of the uterus, as measured fluorimetrically. This high transmitter level persisted even if the oestrogen administration was interrupted after half the experimental period. No changes occurred in the noradrenaline content of the control organs (heart and ovary) which are innervated by ordinary long adrenergic neurons from the sympathetic chain. The significance of the present results for the marked changes in uterine noradrenaline previously found during pregnancy is discussed.

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