Effects of nerve growth factor and its antiserum on axonal regeneration of short adrenergic neurons in the male mouse

1974 ◽  
Vol 150 (3) ◽  
Author(s):  
Bo Bjerre ◽  
Evald Rosengren
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Male Mouse ◽  
Axonal Regeneration ◽  
Nerve Growth ◽  
Adrenergic Neurons ◽  
Short Adrenergic Neurons

Nerve Growth Factor Enhances Nerve Regeneration through Fibronectin Grafts

1996 ◽  
Vol 21 (4) ◽  
pp. 514-522 ◽  
Author(s):  
I. H. WHITWORTH ◽  
R. A. BROWN ◽  
C. J. DORÉ ◽  
P. ANAND ◽  
C. J. GREEN ◽  
...  
Keyword(s):  
Image Analysis ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Schwann Cell ◽  
Nerve Regeneration ◽  
Axonal Regeneration ◽  
Cell Regeneration ◽  
Nerve Growth ◽  
Computerized Image Analysis ◽  
Immunohistochemical Techniques

Soluble fibronectin and nerve growth factor (NGF) promote axonal regeneration when placed in silicone tubes. We investigated the ability of orientated fibronectin mats to bind and release bioactive NGF and the possibility of augmenting axonal regeneration following axotomy by using fibronectin conduits impregnated with NGF. The release of NGF was quantified using a fluorometric ELISA and bioactivity confirmed with a neuronal culture bioassay. Immunohistochemical techniques and computerized image analysis were used to assess the rate and volume of axonal and Schwann cell regeneration. The delivery of NGF to the site of injury produced an increase in the rate ( P≤0.007) and volume ( P≤0.004) of both axonal and Schwann cell regeneration when compared to conduits of plain fibronectin. We conclude that the local delivery of NGF by impregnated fibronectin conduits enhances axonal regeneration.

Nerve growth factor promotes CNS cholinergic axonal regeneration into acellular peripheral nerve grafts

1991 ◽  
Vol 112 (1) ◽  
pp. 79-88 ◽  
Author(s):  
Theo Hagg ◽  
Adarsh K. Gulati ◽  
M.Ali Behzadian ◽  
H.Lee Vahlsing ◽  
Silvio Varon ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Peripheral Nerve ◽  
Axonal Regeneration ◽  
Nerve Growth ◽  
Nerve Grafts ◽  
Peripheral Nerve Grafts
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