Creating Electrospun Nanofiber-Based Biomimetic Scaffolds for Bone Regeneration

2011 ◽  
pp. 63-100 ◽  
Author(s):  
Eleni Katsanevakis ◽  
Xuejun Wen ◽  
Ning Zhang
Keyword(s):  
Bone Regeneration ◽  
Electrospun Nanofiber ◽  
Biomimetic Scaffolds

Mineralized Nanofibers for Bone Tissue Engineering

2018 ◽  
pp. 461-475 ◽  
Author(s):  
Ozan Karaman
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Three Dimensional ◽  
Bone Grafts ◽  
Tissue Engineering Scaffolds ◽  
Promising Alternative ◽  
Biomimetic Scaffolds

The limitation of orthopedic fractures and large bone defects treatments has brought the focus on fabricating bone grafts that could enhance ostegenesis and vascularization in-vitro. Developing biomimetic materials such as mineralized nanofibers that can provide three-dimensional templates of the natural bone extracellular-matrix is one of the most promising alternative for bone regeneration. Understanding the interactions between the structure of the scaffolds and cells and therefore the control cellular pathways are critical for developing functional bone grafts. In order to enhance bone regeneration, the engineered scaffold needs to mimic the characteristics of composite bone ECM. This chapter reviews the fabrication of and fabrication techniques for fabricating biomimetic bone tissue engineering scaffolds. In addition, the chapter covers design criteria for developing the scaffolds and examples of enhanced osteogenic differentiation outcomes by fabricating biomimetic scaffolds.

scholarly journals Coaxial bioelectrospinning of P34HB/PVA microfibers biomimetic scaffolds with simultaneity cell-laden for improving bone regeneration

2021 ◽  
pp. 110349
Author(s):  
Long Yang ◽  
Yan Zhao ◽  
Dongbing Cui ◽  
Yufei Liu ◽  
Qiang Zou ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Biomimetic Scaffolds

Arginine-Presenting Peptide Hydrogels Decorated with Hydroxyapatite as Biomimetic Scaffolds for Bone Regeneration

2017 ◽  
Vol 18 (11) ◽  
pp. 3541-3550 ◽  
Author(s):  
Moumita Ghosh ◽  
Michal Halperin-Sternfeld ◽  
Irena Grigoriants ◽  
Jaehun Lee ◽  
Ki Tae Nam ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Biomimetic Scaffolds ◽  
Peptide Hydrogels

Mineralized Nanofibers for Bone Tissue Engineering

2017 ◽  
pp. 200-218
Author(s):  
Ozan Karaman
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Three Dimensional ◽  
Bone Grafts ◽  
Tissue Engineering Scaffolds ◽  
Promising Alternative ◽  
Biomimetic Scaffolds

The limitation of orthopedic fractures and large bone defects treatments has brought the focus on fabricating bone grafts that could enhance ostegenesis and vascularization in-vitro. Developing biomimetic materials such as mineralized nanofibers that can provide three-dimensional templates of the natural bone extracellular-matrix is one of the most promising alternative for bone regeneration. Understanding the interactions between the structure of the scaffolds and cells and therefore the control cellular pathways are critical for developing functional bone grafts. In order to enhance bone regeneration, the engineered scaffold needs to mimic the characteristics of composite bone ECM. This chapter reviews the fabrication of and fabrication techniques for fabricating biomimetic bone tissue engineering scaffolds. In addition, the chapter covers design criteria for developing the scaffolds and examples of enhanced osteogenic differentiation outcomes by fabricating biomimetic scaffolds.

Designing biomimetic scaffolds for bone regeneration: why aim for a copy of mature tissue properties if nature uses a different approach?

Soft Matter ◽  
2010 ◽  
Vol 6 (20) ◽  
pp. 4976 ◽  
Author(s):  
Bettina M. Willie ◽  
Ansgar Petersen ◽  
Katharina Schmidt-Bleek ◽  
Amaia Cipitria ◽  
Manav Mehta ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tissue Properties ◽  
Biomimetic Scaffolds

Robust silk fibroin/bacterial cellulose nanoribbon composite scaffolds with radial lamellae and intercalation structure for bone regeneration

2017 ◽  
Vol 5 (20) ◽  
pp. 3640-3650 ◽  
Author(s):  
Jian Chen ◽  
Ao Zhuang ◽  
Huili Shao ◽  
Xuechao Hu ◽  
Yaopeng Zhang
Keyword(s):  
Mechanical Properties ◽  
Bone Regeneration ◽  
Bacterial Cellulose ◽  
Silk Fibroin ◽  
Composite Scaffolds ◽  
Biomimetic Scaffolds

Biomimetic scaffolds with a gradient gap distance and robust mechanical properties were prepared using silk fibroin and bacterial cellulose.

scholarly journals The Use of Electrospun Organic and Carbon Nanofibers in Bone Regeneration

Nanomaterials ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 562 ◽  
Author(s):  
Kaoru Aoki ◽  
Hisao Haniu ◽  
Yoong Ahm Kim ◽  
Naoto Saito
Keyword(s):  
Regenerative Medicine ◽  
Bone Regeneration ◽  
Carbon Nanofibers ◽  
High Voltage ◽  
Electrospun Nanofibers ◽  
Bone Defects ◽  
Electrospun Nanofiber ◽  
Medical Field ◽  
Electrospinning Method ◽  
Potential Use

There has been an increasing amount of research on regenerative medicine for the treatment of bone defects. Scaffolds are needed for the formation of new bone, and various scaffolding materials have been evaluated for bone regeneration. Materials with pores that allow cells to differentiate into osteocytes are preferred in scaffolds for bone regeneration, and porous materials and fibers are well suited for this application. Electrospinning is an effective method for producing a nanosized fiber by applying a high voltage to the needle tip containing a polymer solution. The use of electrospun nanofibers is being studied in the medical field, and its use as a scaffold for bone regeneration therapy has become a topic of growing interest. In this review, we will introduce the potential use of electrospun nanofiber as a scaffold for bone regenerative medicine with a focus on carbon nanofibers produced by the electrospinning method.

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