The “Yin and Yang” of Immunomodulatory Magnesium‐Enriched Graphene Oxide Nanoscrolls Decorated Biomimetic Scaffolds in Promoting Bone Regeneration

2020 ◽  
pp. 2000631
Author(s):  
Zhiwei Zheng ◽  
Yahong Chen ◽  
Hao Hong ◽  
Yi Shen ◽  
Yun Wang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Bone Regeneration ◽  
Biomimetic Scaffolds ◽  
Yin And Yang

scholarly journals Cisplatin-Loaded Graphene Oxide/Chitosan/Hydroxyapatite Composite as a Promising Tool for Osteosarcoma-Affected Bone Regeneration

ACS Omega ◽  
2018 ◽  
Vol 3 (11) ◽  
pp. 14620-14633 ◽  
Author(s):  
Murugan Sumathra ◽  
Kishor Kumar Sadasivuni ◽  
S. Suresh Kumar ◽  
Mariappan Rajan
Keyword(s):  
Graphene Oxide ◽  
Bone Regeneration ◽  
Promising Tool ◽  
Hydroxyapatite Composite

Mineralized Nanofibers for Bone Tissue Engineering

2018 ◽  
pp. 461-475 ◽  
Author(s):  
Ozan Karaman
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Three Dimensional ◽  
Bone Grafts ◽  
Tissue Engineering Scaffolds ◽  
Promising Alternative ◽  
Biomimetic Scaffolds

The limitation of orthopedic fractures and large bone defects treatments has brought the focus on fabricating bone grafts that could enhance ostegenesis and vascularization in-vitro. Developing biomimetic materials such as mineralized nanofibers that can provide three-dimensional templates of the natural bone extracellular-matrix is one of the most promising alternative for bone regeneration. Understanding the interactions between the structure of the scaffolds and cells and therefore the control cellular pathways are critical for developing functional bone grafts. In order to enhance bone regeneration, the engineered scaffold needs to mimic the characteristics of composite bone ECM. This chapter reviews the fabrication of and fabrication techniques for fabricating biomimetic bone tissue engineering scaffolds. In addition, the chapter covers design criteria for developing the scaffolds and examples of enhanced osteogenic differentiation outcomes by fabricating biomimetic scaffolds.

scholarly journals Enhanced Cell Proliferation and Osteogenesis Differentiation through a Combined Treatment of Poly-L-Lysine-Coated PLGA/Graphene Oxide Hybrid Fiber Matrices and Electrical Stimulation

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Jiaqi Zhu ◽  
Zhiping Qi ◽  
Changjun Zheng ◽  
Pan Xue ◽  
Chuan Fu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Proliferation ◽  
Graphene Oxide ◽  
Electrical Stimulation ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Cellular Response ◽  
Hybrid Fiber ◽  
Fiber Matrices

Bone tissue engineering scaffold provides an effective treatment for bone defect repair. Biodegradable bone scaffold made of various synthetic and natural materials can be used as bone substitutes and grafts for defect site, which has great potential to support bone regeneration. Regulation of cell-scaffold material interactions is an important factor for modulating the cellular activity in bone tissue engineering scaffold applications. Thus, the hydrophilic, mechanical, and chemical properties of scaffold materials directly affect the results of bone regeneration and functional recovery. In this study, a poly-L-lysine (PLL) surface-modified poly(lactic-co-glycolic acid) (PLGA)/graphene oxide (GO) (PLL-PLGA/GO) hybrid fiber matrix was fabricated for bone tissue regeneration. Characterization of the resultant hybrid fiber matrices was done using scanning electron microscopy (SEM), contact angle, and a material testing machine. According to the results obtained from the test above, the PLL-PLGA/GO hybrid fiber matrices exhibited high wettability and mechanical strength. The special surface characteristics of PLL-PLGA/GO hybrid fiber matrices were more beneficial for protein adsorption and inhibit the proliferation of pathogens. Moreover, the enhanced regulation of MC3T3-E1 cell proliferation and differentiation was observed, when the resultant hybrid fiber matrices were combined with electrical stimulation (ES). The cellular response of MC3T3-E1 cells including cell adhesion, proliferation, alkaline phosphatase (ALP) activity, calcium deposition, and osteogenesis-related gene expression was significantly enhanced with the synergistic effect of resultant hybrid fiber matrices and ES. These data indicate that the PLL-PLGA/GO hybrid fiber matrices supported the cellular response in terms of cell proliferation and osteogenesis differentiation in the presence of electrical stimulation, which could be a potential treatment for bone defect.

scholarly journals The Impact of Graphene Oxide on Bone Regeneration Therapies

10.5772/63333 ◽  
2016 ◽  
Author(s):  
Anca Hermenean ◽  
Sorina Dinescu ◽  
Mariana Ionita ◽  
Marieta Costache
Keyword(s):  
Graphene Oxide ◽  
Bone Regeneration ◽  
The Impact

scholarly journals Enhanced bioactivity and osteoinductivity of carboxymethyl chitosan/nanohydroxyapatite/graphene oxide nanocomposites

RSC Advances ◽  
2018 ◽  
Vol 8 (32) ◽  
pp. 17860-17877 ◽  
Author(s):  
Zhang Yu ◽  
Caiwen Xiao ◽  
Yazhuo Huang ◽  
Mingjiao Chen ◽  
Wei Wei ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Surface Chemistry ◽  
Bone Regeneration ◽  
Calcium Ions ◽  
Carboxymethyl Chitosan

The CMC/nHA/GO scaffold with the surface chemistry and roughness dual effects and the release of phosphate and calcium ions synergistically assist the mineralization and facilitate the bone regeneration.

scholarly journals Evaluation of the Biocompatibility of CS-Graphene Oxide Compounds In Vivo

2019 ◽  
Vol 20 (7) ◽  
pp. 1572 ◽  
Author(s):  
Diego López Tenorio ◽  
Carlos Valencia ◽  
Cesar Valencia ◽  
Fabio Zuluaga ◽  
Mayra Valencia ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Bone Regeneration ◽  
Wistar Rats ◽  
Biomechanical Properties ◽  
Cellular Membrane ◽  
In Vivo Studies ◽  
New Bone Formation ◽  
Critical Size Defects ◽  
Tissue Recovery

In the last few years, graphene oxide (GO) has gained considerable importance in scaffold preparation for tissue engineering due to the presence of functional groups that allow the interaction between the extracellular matrix and the components of the cellular membrane. The interaction between GO and chitosan (CS) can not only improve the biomechanical properties of the scaffold but also generate a synergistic effect, facilitating tissue recovery. In vivo studies on GO are scarce; therefore, biocompatibility tests on CS-GO scaffolds and bone regeneration experiments on critical size defects were carried out on Wistar rats. Scaffolds made of CS, CS-GO 0.5%, and CS-GO 1% were prepared and implanted on Wistar rats cranial bones for three months. Scaffold samples were analyzed through histochemistry and scanning electron microscopy. The analysis performed showed reabsorption of the material by phagocytic activity and new bone formation. The CS-GO 0.5% formulation gave the best performance in bone regeneration, with excellent biocompatibility. These results show the potential of this compound for tissue regeneration opening and medical applications.

Graphene oxide-coated guided bone regeneration membranes with enhanced osteogenesis: Spectroscopic analysis and animal study

2016 ◽  
Vol 51 (7-9) ◽  
pp. 540-551 ◽  
Author(s):  
Keun Oh Park ◽  
Jong Ho Lee ◽  
Ji Hoon Park ◽  
Yong Cheol Shin ◽  
Jung Bo Huh ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Bone Regeneration ◽  
Animal Study ◽  
Spectroscopic Analysis ◽  
Guided Bone Regeneration
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