scholarly journals A review of biomimetic scaffolds for bone regeneration: Toward a cell‐free strategy

2020 ◽  
Author(s):  
Sijing Jiang ◽  
Mohan Wang ◽  
Jiacai He
Keyword(s):  
Bone Regeneration ◽  
Biomimetic Scaffolds ◽  
A Cell

Mineralized Nanofibers for Bone Tissue Engineering

2018 ◽  
pp. 461-475 ◽  
Author(s):  
Ozan Karaman
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Three Dimensional ◽  
Bone Grafts ◽  
Tissue Engineering Scaffolds ◽  
Promising Alternative ◽  
Biomimetic Scaffolds

The limitation of orthopedic fractures and large bone defects treatments has brought the focus on fabricating bone grafts that could enhance ostegenesis and vascularization in-vitro. Developing biomimetic materials such as mineralized nanofibers that can provide three-dimensional templates of the natural bone extracellular-matrix is one of the most promising alternative for bone regeneration. Understanding the interactions between the structure of the scaffolds and cells and therefore the control cellular pathways are critical for developing functional bone grafts. In order to enhance bone regeneration, the engineered scaffold needs to mimic the characteristics of composite bone ECM. This chapter reviews the fabrication of and fabrication techniques for fabricating biomimetic bone tissue engineering scaffolds. In addition, the chapter covers design criteria for developing the scaffolds and examples of enhanced osteogenic differentiation outcomes by fabricating biomimetic scaffolds.

scholarly journals Bone Regeneration in Defects Compromised by Radiotherapy

2009 ◽  
Vol 89 (1) ◽  
pp. 77-81 ◽  
Author(s):  
W.-W. Hu ◽  
B.B. Ward ◽  
Z. Wang ◽  
P.H. Krebsbach
Keyword(s):  
Bone Regeneration ◽  
Bone Development ◽  
Micro Ct ◽  
Mineral Density ◽  
Woven Bone ◽  
Before And After ◽  
Biomaterial Scaffolds ◽  
A Cell ◽  
Previously Treated ◽  
Freely Suspended

Because bone reconstruction in irradiated sites is less than ideal, we applied a regenerative gene therapy method in which a cell-signaling virus was localized to biomaterial scaffolds to regenerate wounds compromised by radiation therapy. Critical-sized defects were created in rat calvariae previously treated with radiation. Gelatin scaffolds containing lyophilized adenovirus encoding BMP-2 (AdBMP-2) or freely suspended AdBMP-2 were transplanted. Lyophilized AdBMP-2 significantly improved bone quality and quantity over free AdBMP-2. Bone mineral density was reduced after radiotherapy. Histological analyses demonstrated that radiation damage led to less bone regeneration. The woven bone and immature marrow formed in the radiated defects indicated that irradiation retarded normal bone development. Finally, we stored the scaffolds with lyophilized AdBMP-2 at −80°C to determine adenovirus stability. Micro-CT quantification demonstrated no significant differences between bone regeneration treated with lyophilized AdBMP-2 before and after storage, suggesting that virus-loaded scaffolds may be convenient for application as pre-made constructs.

Preparation of Silicon-Containing Poly(lactic acid)-Vaterite Hybrid Membranes

2010 ◽  
Vol 638-642 ◽  
pp. 670-674
Author(s):  
Akiko Obata ◽  
Takashi Wakita ◽  
Yoshio Ota ◽  
Toshihiro Kasuga
Keyword(s):  
Lactic Acid ◽  
Simulated Body Fluid ◽  
Bone Regeneration ◽  
Trace Amount ◽  
Body Fluid ◽  
Poly Lactic Acid ◽  
Osteogenic Cells ◽  
A Cell ◽  
Silicon Doped ◽  
Gbr Membrane

Microfiber meshes releasing a trace amount of silicon species were prepared by electrospinning silicon-doped vaterite (SiV) and poly(lactic acid) (PLA) hybrids for application to membranes for guided bone regeneration (GBR). A trace amount of silicon-species has been reported to enhance the mineralization and bone-forming abilities of osteogenic cells. The microfiber meshes prepared by electrospinning are regarded to be a useful candidate for the GBR membrane, because they have adequate flexibility and porosity for it. In this study, hydroxyapatite (HA)-forming abilities in simulated body fluid, silicon-releasabilities, compatibility with osteoblast-like cells of the prepared microfiber meshes were examined. The meshes were completely coated with HA after soaking in simulated body fluid for 1 day. The meshes coated with HA released 0.2 -0.7 mg/L of silicon species in a cell culture medium for 7 days. The cells elongated on the microfibers of the meshes and some of them entered the mesh after 1 day-culturing. The meshes are expected to provide an excellent substrate for bone regeneration and enhance bone-forming ability of the cells.

scholarly journals Coaxial bioelectrospinning of P34HB/PVA microfibers biomimetic scaffolds with simultaneity cell-laden for improving bone regeneration

2021 ◽  
pp. 110349
Author(s):  
Long Yang ◽  
Yan Zhao ◽  
Dongbing Cui ◽  
Yufei Liu ◽  
Qiang Zou ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Biomimetic Scaffolds

Arginine-Presenting Peptide Hydrogels Decorated with Hydroxyapatite as Biomimetic Scaffolds for Bone Regeneration

2017 ◽  
Vol 18 (11) ◽  
pp. 3541-3550 ◽  
Author(s):  
Moumita Ghosh ◽  
Michal Halperin-Sternfeld ◽  
Irena Grigoriants ◽  
Jaehun Lee ◽  
Ki Tae Nam ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Biomimetic Scaffolds ◽  
Peptide Hydrogels

Bioengineered mussel glue incorporated with a cell recognition motif as an osteostimulating bone adhesive for titanium implants

2015 ◽  
Vol 3 (41) ◽  
pp. 8102-8114 ◽  
Author(s):  
Yun Kee Jo ◽  
Bong-Hyuk Choi ◽  
Cong Zhou ◽  
Jin-Soo Ahn ◽  
Sang Ho Jun ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Titanium Implants ◽  
Osteoblastic Cell ◽  
Cell Recognition ◽  
Cell Behaviors ◽  
Recognition Motif ◽  
A Cell

An engineered mussel glue MAP-RGD can be successfully used as a novel functional osteostimulating bone adhesive for titanium implants through improved osteoblastic cell behaviors, blood responses, and eventually enhanced bone regeneration.

Mineralized Nanofibers for Bone Tissue Engineering

2017 ◽  
pp. 200-218
Author(s):  
Ozan Karaman
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Three Dimensional ◽  
Bone Grafts ◽  
Tissue Engineering Scaffolds ◽  
Promising Alternative ◽  
Biomimetic Scaffolds

The limitation of orthopedic fractures and large bone defects treatments has brought the focus on fabricating bone grafts that could enhance ostegenesis and vascularization in-vitro. Developing biomimetic materials such as mineralized nanofibers that can provide three-dimensional templates of the natural bone extracellular-matrix is one of the most promising alternative for bone regeneration. Understanding the interactions between the structure of the scaffolds and cells and therefore the control cellular pathways are critical for developing functional bone grafts. In order to enhance bone regeneration, the engineered scaffold needs to mimic the characteristics of composite bone ECM. This chapter reviews the fabrication of and fabrication techniques for fabricating biomimetic bone tissue engineering scaffolds. In addition, the chapter covers design criteria for developing the scaffolds and examples of enhanced osteogenic differentiation outcomes by fabricating biomimetic scaffolds.

scholarly journals Bioprinting a cell‐laden matrix for bone regeneration: A focused review

2020 ◽  
Vol 138 (8) ◽  
pp. 49888
Author(s):  
Farnaz Ghorbani ◽  
Dejian Li ◽  
Zeyuan Zhong ◽  
Melika Sahranavard ◽  
Zhi Qian ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
A Cell
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