Plasma assisted deposition of free-standing nanofilms for biomedical applications

2016 ◽  
Vol 13 (12) ◽  
pp. 1224-1229 ◽  
Author(s):  
Daniela Pignatelli ◽  
Eloisa Sardella ◽  
Fabio Palumbo ◽  
Chiara Lo Porto ◽  
Silvia Taccola ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Free Standing

scholarly journals Surface modification and cellular uptake evaluation of Au-coated Ni 80 Fe 20 nanodiscs for biomedical applications

2016 ◽  
Vol 6 (6) ◽  
pp. 20160052 ◽  
Author(s):  
Gabriele Barrera ◽  
Loredana Serpe ◽  
Federica Celegato ◽  
Marco Coїsson ◽  
Katia Martina ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Vortex Formation ◽  
Fluorescein Isothiocyanate ◽  
Gold Surface ◽  
Gold Layer ◽  
Temperature Hysteresis ◽  
Free Standing ◽  
Self Assembling ◽  
Polystyrene Nanospheres ◽  
Nanofabrication Technique

A nanofabrication technique based on self-assembling of polystyrene nanospheres is used to obtain magnetic Ni 80 Fe 20 nanoparticles with a disc shape. The free-standing nanodiscs (NDs) have diameter and thickness of about 630 nm and 30 nm, respectively. The versatility of fabrication technique allows one to cover the ND surface with a protective gold layer with a thickness of about 5 nm. Magnetization reversal has been studied by room-temperature hysteresis loop measurements in water-dispersed free-standing NDs. The reversal shows zero remanence, high susceptibility and nucleation/annihilation fields due to spin vortex formation. In order to investigate their potential use in biomedical applications, the effect of NDs coated with or without the protective gold layer on cell growth has been evaluated. A successful attempt to bind cysteine-fluorescein isothiocyanate (FITC) derivative to the gold surface of magnetic NDs has been exploited to verify the intracellular uptake of the NDs by cytofluorimetric analysis using the FITC conjugate.

SiC for Biomedical Applications

2016 ◽  
Vol 858 ◽  
pp. 1010-1014 ◽  
Author(s):  
Stephen E. Saddow ◽  
Christopher L. Frewin ◽  
Fabiola Araujo Cespedes ◽  
Marioa Gazziro ◽  
Evans Bernadin ◽  
...  
Keyword(s):  
Silicon Carbide ◽  
Biomedical Applications ◽  
Glucose Monitoring ◽  
Wide Band ◽  
Neural Interfaces ◽  
Free Standing ◽  
Wide Band Gap ◽  
Custom Made ◽  
Biological World ◽  
Machine Interface

Silicon carbide is a well-known wide-band gap semiconductor traditionally used in power electronics and solid-state lighting due to its extremely low intrinsic carrier concentration and high thermal conductivity. What is only recently being discovered is that it possesses excellent compatibility within the biological world. Since publication of the first edition of Silicon Carbide Biotechnology: A Biocompatible Semiconductor for Advanced Biomedical Devices and Applications five years ago [1], significant progress has been made on numerous research and development fronts. In this paper three very promising developments are briefly highlighted – progress towards the realization of a continuous glucose monitoring system, implantable neural interfaces made from free-standing 3C-SiC, and a custom-made low-power ‘wireless capable’ four channel neural recording chip for brain-machine interface applications.

scholarly journals Insulating and semiconducting polymeric free-standing nanomembranes with biomedical applications

2015 ◽  
Vol 3 (29) ◽  
pp. 5904-5932 ◽  
Author(s):  
Maria M. Pérez-Madrigal ◽  
Elaine Armelin ◽  
Jordi Puiggalí ◽  
Carlos Alemán
Keyword(s):  
Conducting Polymers ◽  
Biomedical Applications ◽  
Free Standing

Free-standing nanomembranes, which are emerging as versatile elements in biomedical applications, are evolving from being composed of insulating (bio)polymers to electroactive conducting polymers.

scholarly journals Surface Engineered Iron Oxide Nanoparticles Generated by Inert Gas Condensation for Biomedical Applications

2021 ◽  
Vol 8 (3) ◽  
pp. 38
Author(s):  
Aver Hemben ◽  
Iva Chianella ◽  
Glenn John Thomas Leighton
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Physical Vapor Deposition ◽  
Biomedical Applications ◽  
Inert Gas ◽  
Oxide Nanoparticles ◽  
Free Standing ◽  
Gas Condensation ◽  
Inert Gas Condensation ◽  
Novel Method

Despite the lifesaving medical discoveries of the last century, there is still an urgent need to improve the curative rate and reduce mortality in many fatal diseases such as cancer. One of the main requirements is to find new ways to deliver therapeutics/drugs more efficiently and only to affected tissues/organs. An exciting new technology is nanomaterials which are being widely investigated as potential nanocarriers to achieve localized drug delivery that would improve therapy and reduce adverse drug side effects. Among all the nanocarriers, iron oxide nanoparticles (IONPs) are one of the most promising as, thanks to their paramagnetic/superparamagnetic properties, they can be easily modified with chemical and biological functions and can be visualized inside the body by magnetic resonance imaging (MRI), while delivering the targeted therapy. Therefore, iron oxide nanoparticles were produced here with a novel method and their properties for potential applications in both diagnostics and therapeutics were investigated. The novel method involves production of free standing IONPs by inert gas condensation via the Mantis NanoGen Trio physical vapor deposition system. The IONPs were first sputtered and deposited on plasma cleaned, polyethylene glycol (PEG) coated silicon wafers. Surface modification of the cleaned wafer with PEG enabled deposition of free-standing IONPs, as once produced, the soft-landed IONPs were suspended by dissolution of the PEG layer in water. Transmission electron microscopic (TEM) characterization revealed free standing, iron oxide nanoparticles with size < 20 nm within a polymer matrix. The nanoparticles were analyzed also by Atomic Force Microscope (AFM), Dynamic Light Scattering (DLS) and NanoSight Nanoparticle Tacking Analysis (NTA). Therefore, our work confirms that inert gas condensation by the Mantis NanoGen Trio physical vapor deposition sputtering at room temperature can be successfully used as a scalable, reproducible process to prepare free-standing IONPs. The PEG- IONPs produced in this work do not require further purification and thanks to their tunable narrow size distribution have potential to be a powerful tool for biomedical applications.

scholarly journals Biofabrication using maize protein: 3D printing using zein formulations

2020 ◽  
Author(s):  
Jorge Alfonso Tavares-Negrete ◽  
Alberto Emanuel Aceves-Colin ◽  
Delia Cristal Rivera-Flores ◽  
Gladys Guadalupe Díaz-Armas ◽  
Anne-Sophie Mertgen ◽  
...  
Keyword(s):  
3D Printing ◽  
Apparent Viscosity ◽  
Biomedical Applications ◽  
Three Dimensional ◽  
Controlled Drug Release ◽  
Free Standing ◽  
Maize Seeds ◽  
Maize Protein ◽  
Protein Matrices ◽  
Printing Parameters

AbstractThe use of three-dimensional (3D) printing for biomedical applications has expanded exponentially in recent years. However, the current portfolio of 3D printable inks is still limited. For instance, only a few protein matrices have been explored as printing/bioprinting materials. Here, we introduce the use of zein, the primary constitutive protein in maize seeds, as a 3D-printable material. Zein-based inks were prepared by dissolving commercial zein powder in ethanol with or without polyethylene glycol (PEG400) as a plasticizer. The rheological characteristics of our materials, studied during 21 days of aging/maturation, showed an increase in the apparent viscosity as a function of time in all formulations. The addition of PEG 400 decreased the apparent viscosity. Inks with and without PEG400 and at different maturation times were tested for printability in a BioX bioprinter. We optimized the 3D printing parameters for each ink formulation in terms of extrusion pressure and linear printing velocity. Higher fidelity structures were obtained with inks that had maturation times of 10 to 14 days. We present different proof-of-concept experiments to demonstrate the versatility of the engineered zein inks for diverse biomedical applications. These include printing of complex and/or free-standing 3D structures, materials for controlled drug release, and scaffolds for cell culture.

scholarly journals Large-scale fabrication of free-standing and sub-μm PDMS through-hole membranes

Nanoscale ◽  
2018 ◽  
Vol 10 (16) ◽  
pp. 7711-7718 ◽  
Author(s):  
Hai Le-The ◽  
Martijn Tibbe ◽  
Joshua Loessberg-Zahl ◽  
Marciano Palma do Carmo ◽  
Marinke van der Helm ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Large Scale ◽  
Free Standing ◽  
Simple Method ◽  
Through Hole

A robust and simple method was developed for large-scale fabrication of free-standing and sub-μm PDMS through-hole membranes for biomedical applications.

Adhesive free-standing multilayer films containing sulfated levan for biomedical applications

2018 ◽  
Vol 69 ◽  
pp. 183-195 ◽  
Author(s):  
Tiago D. Gomes ◽  
Sofia G. Caridade ◽  
Maria P. Sousa ◽  
Sara Azevedo ◽  
Muhammed Y. Kandur ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Multilayer Films ◽  
Free Standing

Co/Pd-Based synthetic antiferromagnetic thin films on Au/resist underlayers: towards biomedical applications

Nanoscale ◽  
2019 ◽  
Vol 11 (45) ◽  
pp. 21891-21899 ◽  
Author(s):  
G. Varvaro ◽  
S. Laureti ◽  
D. Peddis ◽  
M. Hassan ◽  
G. Barucca ◽  
...  
Keyword(s):  
Thin Film ◽  
Thin Films ◽  
Magnetic Anisotropy ◽  
Magnetic Moment ◽  
Biomedical Applications ◽  
Perpendicular Magnetic Anisotropy ◽  
Starting Material ◽  
Free Standing ◽  
Theranostic Applications

Thin film stacks made of multiple repeats of Co/Pd-based SAF units with perpendicular magnetic anisotropy and tunable magnetic moment were explored as starting material to fabricate free-standing micro/nanodisks for theranostic applications.

scholarly journals Ultrananocrystalline diamond-coated nanoporous membranes support SK-N-SH neuroblastoma endothelial cell attachment

2018 ◽  
Vol 8 (3) ◽  
pp. 20170063 ◽  
Author(s):  
Kai-Hung Yang ◽  
Alexander K. Nguyen ◽  
Peter L. Goering ◽  
Anirudha V. Sumant ◽  
Roger J. Narayan
Keyword(s):  
Electron Microscopy ◽  
Silicon Nitride ◽  
Single Molecule ◽  
Photoelectron Spectroscopy ◽  
Biomedical Applications ◽  
Cell Attachment ◽  
Nanoporous Membranes ◽  
Free Standing ◽  
Tissue Engineering Scaffolds ◽  
Ultrananocrystalline Diamond

Ultrananocrystalline diamond (UNCD) has been demonstrated to have attractive features for biomedical applications and can be combined with nanoporous membranes for applications in drug delivery systems, biosensing, immunoisolation and single molecule analysis. In this study, free-standing nanoporous UNCD membranes with pore sizes of 100 or 400 nm were fabricated by directly depositing ultrathin UNCD films on nanoporous silicon nitride membranes and then etching away silicon nitride using reactive ion etching. Successful deposition of UNCD on the substrate with a novel process was confirmed with Raman spectroscopy, X-ray photoelectron spectroscopy, cross-section scanning electron microscopy (SEM) and transmission electron microscopy. Both sample types exhibited uniform geometry and maintained a clear hexagonal pore arrangement. Cellular attachment of SK-N-SH neuroblastoma endothelial cells was examined using confocal microscopy and SEM. Attachment of SK-N-SH cells onto UNCD membranes on both porous regions and solid surfaces was shown, indicating the potential use of UNCD membranes in biomedical applications such as biosensors and tissue engineering scaffolds.

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