scholarly journals Surface modification and cellular uptake evaluation of Au-coated Ni 80 Fe 20 nanodiscs for biomedical applications

2016 ◽  
Vol 6 (6) ◽  
pp. 20160052 ◽  
Author(s):  
Gabriele Barrera ◽  
Loredana Serpe ◽  
Federica Celegato ◽  
Marco Coїsson ◽  
Katia Martina ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Vortex Formation ◽  
Fluorescein Isothiocyanate ◽  
Gold Surface ◽  
Gold Layer ◽  
Temperature Hysteresis ◽  
Free Standing ◽  
Self Assembling ◽  
Polystyrene Nanospheres ◽  
Nanofabrication Technique

A nanofabrication technique based on self-assembling of polystyrene nanospheres is used to obtain magnetic Ni 80 Fe 20 nanoparticles with a disc shape. The free-standing nanodiscs (NDs) have diameter and thickness of about 630 nm and 30 nm, respectively. The versatility of fabrication technique allows one to cover the ND surface with a protective gold layer with a thickness of about 5 nm. Magnetization reversal has been studied by room-temperature hysteresis loop measurements in water-dispersed free-standing NDs. The reversal shows zero remanence, high susceptibility and nucleation/annihilation fields due to spin vortex formation. In order to investigate their potential use in biomedical applications, the effect of NDs coated with or without the protective gold layer on cell growth has been evaluated. A successful attempt to bind cysteine-fluorescein isothiocyanate (FITC) derivative to the gold surface of magnetic NDs has been exploited to verify the intracellular uptake of the NDs by cytofluorimetric analysis using the FITC conjugate.

Large-area patterned magnetic nanostructures by self-assembling of polystyrene nanospheres

2012 ◽  
Vol 1411 ◽  
Author(s):  
Paola Tiberto ◽  
Luca Boarino ◽  
Federica Celegato ◽  
Gabriele Barrera ◽  
Marco Coisson ◽  
...  
Keyword(s):  
Magnetic Nanostructures ◽  
Magnetic Domain ◽  
Hysteresis Loops ◽  
Gradient Field ◽  
Temperature Hysteresis ◽  
Mutual Distance ◽  
Large Area ◽  
Advantages And Disadvantages ◽  
Self Assembling ◽  
Polystyrene Nanospheres

ABSTRACTIn this work, dot and anti-dot structures in Co, Ni, Ni80Fe20, Fe50Pd50, Fe73.5Cu1Nb3Si13.5B9 and Fe78B13Si9 thin films have been produced by means of nanosphere lithography. Two multi-step processes have been followed and will be here described. The first one directly exploits polystyrene nanosheres (PN) as a mask to fabricate arrays of magnetic nanoholes and dots. In the second case, the nanospheres are used to design a polymeric mask of a photoresist subsequently used to pattern a magnetic nanostructure on a film. Advantages and disadvantages of the two lithographical techniques will be here highlighted. In both processes, the dimension and mutual distance of the patterns are dependent on the starting PN diameter (in the interval 500-800 nm). Samples microstructure has been studied by means of SEM and AFM microscopy. Room-temperature hysteresis loops have been measured by an AGFM (Alternating Gradient Field Magnetometer). MFM microscopy has been exploited to study the magnetic domain pattern. All produced systems have been observed to display tunable microstructure and, consequently, various magnetic properties for application.

Surface characterization and thermomechanical behavior of nanostructured-gold layer for biomedical applications

2019 ◽  
Vol 782 ◽  
pp. 1114-1120 ◽  
Author(s):  
Chi-Ming Wu ◽  
Yi-Jung Lu ◽  
Shyuan-Yow Chen ◽  
Shih-Cheng Wen ◽  
Chia-Hung Wu ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Surface Characterization ◽  
Thermomechanical Behavior ◽  
Gold Layer ◽  
Nanostructured Gold

scholarly journals A New Hope: Self-Assembling Peptides with Antimicrobial Activity

Pharmaceutics ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 166 ◽  
Author(s):  
Lucia Lombardi ◽  
Annarita Falanga ◽  
Valentina Del Genio ◽  
Stefania Galdiero
Keyword(s):  
Self Assembly ◽  
Biomedical Applications ◽  
High Specificity ◽  
Antibacterial Activities ◽  
Mechanisms Of Action ◽  
Great Promise ◽  
Functional Nanomaterials ◽  
Self Assembling ◽  
Low Toxicity ◽  
Bio Compatibility

Peptide drugs hold great promise for the treatment of infectious diseases thanks to their novel mechanisms of action, low toxicity, high specificity, and ease of synthesis and modification. Naturally developing self-assembly in nature has inspired remarkable interest in self-assembly of peptides to functional nanomaterials. As a matter of fact, their structural, mechanical, and functional advantages, plus their high bio-compatibility and bio-degradability make them excellent candidates for facilitating biomedical applications. This review focuses on the self-assembly of peptides for the fabrication of antibacterial nanomaterials holding great interest for substituting antibiotics, with emphasis on strategies to achieve nano-architectures of self-assembly. The antibacterial activities achieved by these nanomaterials are also described.

Plasma assisted deposition of free-standing nanofilms for biomedical applications

2016 ◽  
Vol 13 (12) ◽  
pp. 1224-1229 ◽  
Author(s):  
Daniela Pignatelli ◽  
Eloisa Sardella ◽  
Fabio Palumbo ◽  
Chiara Lo Porto ◽  
Silvia Taccola ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Free Standing

scholarly journals Overview of DNA Self-Assembling: Progresses in Biomedical Applications

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 268 ◽  
Author(s):  
Andreia Jorge ◽  
Ramon Eritja
Keyword(s):  
Programming Languages ◽  
Biomedical Applications ◽  
Great Promise ◽  
Dna Nanostructures ◽  
Modular Assembly ◽  
Molecular Programming ◽  
Self Assembling ◽  
Theranostic Agents ◽  
Assembly Principles

Molecular self-assembling is ubiquitous in nature providing structural and functional machinery for the cells. In recent decades, material science has been inspired by the nature’s assembly principles to create artificially higher-order structures customized with therapeutic and targeting molecules, organic and inorganic fluorescent probes that have opened new perspectives for biomedical applications. Among these novel man-made materials, DNA nanostructures hold great promise for the modular assembly of biocompatible molecules at the nanoscale of multiple shapes and sizes, designed via molecular programming languages. Herein, we summarize the recent advances made in the designing of DNA nanostructures with special emphasis on their application in biomedical research as imaging and diagnostic platforms, drug, gene, and protein vehicles, as well as theranostic agents that are meant to operate in-cell and in-vivo.

scholarly journals Nanoscale assemblies and their biomedical applications

2013 ◽  
Vol 10 (80) ◽  
pp. 20120740 ◽  
Author(s):  
Tais A. P. F. Doll ◽  
Senthilkumar Raman ◽  
Raja Dey ◽  
Peter Burkhard
Keyword(s):  
Biomedical Applications ◽  
Vaccine Development ◽  
Building Blocks ◽  
Eukaryotic Cells ◽  
Peptide Nanotubes ◽  
Protein Cages ◽  
Bacterial Microcompartments ◽  
Self Assembling ◽  
Development Section ◽  
Characteristic Features

Nanoscale assemblies are a unique class of materials, which can be synthesized from inorganic, polymeric or biological building blocks. The multitude of applications of this class of materials ranges from solar and electrical to uses in food, cosmetics and medicine. In this review, we initially highlight characteristic features of polymeric nanoscale assemblies as well as those built from biological units (lipids, nucleic acids and proteins). We give special consideration to protein nanoassemblies found in nature such as ferritin protein cages, bacterial microcompartments and vaults found in eukaryotic cells and designed protein nanoassemblies, such as peptide nanofibres and peptide nanotubes. Next, we focus on biomedical applications of these nanoscale assemblies, such as cell targeting, drug delivery, bioimaging and vaccine development. In the vaccine development section, we report in more detail the use of virus-like particles and self-assembling polypeptide nanoparticles as new vaccine delivery platforms.

Design of a RADA16-based self-assembling peptide nanofiber scaffold for biomedical applications

2019 ◽  
Vol 30 (9) ◽  
pp. 713-736 ◽  
Author(s):  
Rongrong Wang ◽  
Zhaoyue Wang ◽  
Yayuan Guo ◽  
Hongmin Li ◽  
Zhuoyue Chen
Keyword(s):  
Biomedical Applications ◽  
Nanofiber Scaffold ◽  
Self Assembling
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