Role of Epigenomics in Bone and Cartilage Disease

2019 ◽  
Vol 34 (2) ◽  
pp. e3662 ◽  
Author(s):  
Joyce BJ van Meurs ◽  
Cindy G Boer ◽  
Laura Lopez-Delgado ◽  
Jose A Riancho
Keyword(s):  
Cartilage Disease ◽  
And Cartilage

Cleft Lip Rhinoplasty: The Role of Bone and Cartilage Grafts

1989 ◽  
Vol 16 (1) ◽  
pp. 177-186 ◽  
Author(s):  
Fernando Ortiz Monasterio ◽  
Ernesto J. Ruas
Keyword(s):  
Cleft Lip ◽  
Cartilage Grafts ◽  
And Cartilage

scholarly journals Prostaglandins and Rheumatoid Arthritis

Arthritis ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Mohammad Javad Fattahi ◽  
Abbas Mirshafiey
Keyword(s):  
Rheumatoid Arthritis ◽  
Arachidonic Acid ◽  
Immune Responses ◽  
Cartilage Destruction ◽  
Heterogeneous Population ◽  
Therapeutic Protocol ◽  
Site Of Action ◽  
And Cartilage ◽  
Homeostatic Mechanisms

Rheumatoid arthritis (RA) is a chronic, autoimmune, and complex inflammatory disease leading to bone and cartilage destruction, whose cause remains obscure. Accumulation of genetic susceptibility, environmental factors, and dysregulated immune responses are necessary for mounting this self-reacting disease. Inflamed joints are infiltrated by a heterogeneous population of cellular and soluble mediators of the immune system, such as T cells, B cells, macrophages, cytokines, and prostaglandins (PGs). Prostaglandins are lipid inflammatory mediators derived from the arachidonic acid by multienzymatic reactions. They both sustain homeostatic mechanisms and mediate pathogenic processes, including the inflammatory reaction. They play both beneficial and harmful roles during inflammation, according to their site of action and the etiology of the inflammatory response. With respect to the role of PGs in inflammation, they can be effective mediators in the pathophysiology of RA. Thus the use of agonists or antagonists of PG receptors may be considered as a new therapeutic protocol in RA. In this paper, we try to elucidate the role of PGs in the immunopathology of RA.

scholarly journals The Role of Substance P in the Regulation of Bone and Cartilage Metabolic Activity

2020 ◽  
Vol 11 ◽  
Author(s):  
Fu-Xing-Zi Li ◽  
Feng Xu ◽  
Xiao Lin ◽  
Feng Wu ◽  
Jia-Yu Zhong ◽  
...  
Keyword(s):  
Substance P ◽  
Metabolic Activity ◽  
And Cartilage

scholarly journals Role of Activatory FcγRI and FcγRIII and Inhibitory FcγRII in Inflammation and Cartilage Destruction during Experimental Antigen-Induced Arthritis

2001 ◽  
Vol 159 (6) ◽  
pp. 2309-2320 ◽  
Author(s):  
Peter L.E.M. Van Lent ◽  
Karin Nabbe ◽  
Arjen B. Blom ◽  
Astrid E.M. Holthuysen ◽  
Annet Sloetjes ◽  
...  
Keyword(s):  
Cartilage Destruction ◽  
And Cartilage
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