scholarly journals Combined role of type IX collagen and cartilage oligomeric matrix protein in cartilage matrix assembly: Cartilage oligomeric matrix protein counteracts type IX collagen–induced limitation of cartilage collagen fibril growth in mouse chondrocyte cultures

2009 ◽  
Vol 60 (12) ◽  
pp. 3676-3685 ◽  
Author(s):  
K. Blumbach ◽  
Y. M. Bastiaansen-Jenniskens ◽  
J. DeGroot ◽  
M. Paulsson ◽  
G. J. V. M. van Osch ◽  
...  
Keyword(s):  
Collagen Fibril ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Cartilage Matrix ◽  
Matrix Assembly ◽  
Chondrocyte Cultures ◽  
And Cartilage

scholarly journals 221 COLLAGEN TYPE IX AND CARTILAGE OLIGOMERIC MATRIX PROTEIN INFLUENCE CARTILAGE MATRIX ASSEMBLY

2008 ◽  
Vol 16 ◽  
pp. S104
Author(s):  
Y.M. Bastiaansen-Jenniskens ◽  
K. Blumbach ◽  
W. Koevoet ◽  
M. Paulsson ◽  
J. DeGroot ◽  
...  
Keyword(s):  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Collagen Type ◽  
Cartilage Matrix ◽  
Matrix Assembly ◽  
And Cartilage

In vivo protective effects of upper zone of growth plate and cartilage matrix associated protein against cartilage degeneration in a monosodium iodoacetate induced osteoarthritis model

2020 ◽  
Vol 98 (11) ◽  
pp. 763-770
Author(s):  
Hamza Malik Okuyan ◽  
Menderes Yusuf Terzi ◽  
İhsan Karaboğa ◽  
Serdar Doğan ◽  
Aydıner Kalacı
Keyword(s):  
Growth Plate ◽  
Matrix Protein ◽  
Critical Role ◽  
Cartilage Degeneration ◽  
Cartilage Matrix ◽  
Bone Morphogenetic Protein 2 ◽  
Monosodium Iodoacetate ◽  
And Cartilage

Osteoarthritis (OA) is a degenerative disease affecting the majority of over 65 year old people and characterized by cartilage degeneration, subchondral abnormal changes, and inflammation. Despite the enormous socioeconomic burden caused by OA, currently, there is no effective therapy against it. Upper zone of growth plate and cartilage matrix associated protein (UCMA) is a vitamin K dependent protein and has a critical role in pathophysiological conditions associated with bone and cartilage. However, there is no research on the protective role of intra-articular UCMA treatment in OA pathogenesis. Therefore, we aimed to investigate the potential therapeutic role of UCMA in an in vivo model of OA. We report for the first time that intra-articular UCMA injection ameliorated cartilage degeneration in a monosodium iodoacetate induced OA rat model. Furthermore, the OA-induced activation of nuclear factor kappa B and bone morphogenetic protein 2 signals was attenuated by UCMA. Our results indicated that UCMA decreased cartilage oligomeric matrix protein levels but did not affect interleukin 6, total antioxidant status, and total oxidant status levels in the serum. In conclusion, UCMA exhibited a therapeutic potential in the treatment of OA. This protective effect of UCMA is possibly achieved by reducing the aggrecanase activity and the production of inflammatory cytokines.

scholarly journals Elevated Levels of Cartilage Oligomeric Matrix Protein during In Vitro Cartilage Matrix Generation Decrease Collagen Fibril Diameter

Cartilage ◽  
2010 ◽  
Vol 1 (3) ◽  
pp. 200-210 ◽  
Author(s):  
Y.M. Bastiaansen-Jenniskens ◽  
A.C.W. de Bart ◽  
W. Koevoet ◽  
K.M.B. Jansen ◽  
J.A.N. Verhaar ◽  
...  
Keyword(s):  
Collagen Fibril ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Cartilage Matrix ◽  
Fibril Diameter

scholarly journals Rheumatoid Arthritis: Hyaluronic Acid and Cartilage Oligomeric Matrix Protein as Predictors of the Disease Progression

2016 ◽  
Vol 9 (1) ◽  
pp. 15-23
Author(s):  
SAID AL-DALAEN ◽  
AIMAN AL-QTAITAT ◽  
MOHAMMAD AL-RAWASHDEH ◽  
JIHAD ALZYOUD ◽  
AIMAN AL-MAATHADI
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid ◽  
Disease Progression ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
And Cartilage

scholarly journals Molecular synergy in biolubrication: The role of cartilage oligomeric matrix protein (COMP) in surface-structuring of lubricin

2017 ◽  
Vol 495 ◽  
pp. 200-206 ◽  
Author(s):  
Akanksha Raj ◽  
Min Wang ◽  
Chao Liu ◽  
Liaquat Ali ◽  
Niclas G. Karlsson ◽  
...  
Keyword(s):  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Surface Structuring

scholarly journals Cartilage oligomeric matrix protein enhances matrix assembly during chondrogenesis of human mesenchymal stem cells

2012 ◽  
Vol 113 (4) ◽  
pp. 1245-1252 ◽  
Author(s):  
Hana Haleem-Smith ◽  
Raul Calderon ◽  
Yingjie Song ◽  
Rocky S. Tuan ◽  
Faye H. Chen
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Human Mesenchymal Stem Cells ◽  
Matrix Assembly

scholarly journals Cartilage matrix protein is a component of the collagen fibril of cartilage

1992 ◽  
Vol 193 (3) ◽  
pp. 266-276 ◽  
Author(s):  
Neil Winterbottom ◽  
M. Mehrdad Tondravi ◽  
Terrill L. Harrington ◽  
F. George Klier ◽  
Barbara M. Vertel ◽  
...  
Keyword(s):  
Collagen Fibril ◽  
Matrix Protein ◽  
Cartilage Matrix
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