scholarly journals Front Cover: Structure‐Activity‐Relationship‐Aided Design and Synthesis of xCT Antiporter Inhibitors (ChemMedChem 17/2021)

ChemMedChem ◽  
2021 ◽  
Vol 16 (17) ◽  
pp. 2546-2546
Author(s):  
Davide Cirillo ◽  
Shahin Sarowar ◽  
Per Øyvind Enger ◽  
Hans‐René Bjørsvik
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Front Cover ◽  
Design And Synthesis ◽  
Structure Activity ◽  
Aided Design

scholarly journals Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1)

MedChemComm ◽  
2016 ◽  
Vol 7 (9) ◽  
pp. 1793-1796 ◽  
Author(s):  
H. Ü. Kaniskan ◽  
M. S. Eram ◽  
J. Liu ◽  
D. Smil ◽  
M. L. Martini ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
High Potency ◽  
Arginine Methyltransferase ◽  
Design And Synthesis ◽  
Structure Activity ◽  
Methyltransferase 1

Structure–activity relationship studies, starting from a fragment hit, resulted in discovery of the compound 9, an inhibitor of CARM1 with high potency and selectivity.

scholarly journals Sulfur(vi) fluoride exchange as a key reaction for synthesizing biaryl sulfate core derivatives as potent hepatitis C virus NS5A inhibitors and their structure–activity relationship studies

RSC Advances ◽  
2018 ◽  
Vol 8 (55) ◽  
pp. 31803-31821 ◽  
Author(s):  
Youngsu You ◽  
Hee Sun Kim ◽  
Jung Woo Park ◽  
Gyochang Keum ◽  
Sung Key Jang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Design And Synthesis ◽  
Structure Activity

SuFEx chemistry was utilized for the design and synthesis of potent HCV NS5A inhibitors featuring a biaryl sulfate core.

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