Structure−Activity Relationship of 3-SubstitutedN-(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase:  Design and Synthesis of in Vivo Active Antitumor Compounds

F. George Njoroge; Bancha Vibulbhan; Dinananth F. Rane; W. Robert Bishop; Joanne Petrin; Robert Patton; Mathew S. Bryant; K.-J. Chen; Amin A. Nomeir; C.-C. Lin; Ming Liu; Ivan King; Jianping Chen; Suining Lee; Bohdan Yaremko; Janet Dell; Philip Lipari; Michael Malkowski; Zujun Li; Joseph Catino; Ronald J. Doll; V. Girijavallabhan; Ashit K. Ganguly

doi:10.1021/jm970464g

Structure−Activity Relationship of 3-SubstitutedN-(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase: Design and Synthesis of in Vivo Active Antitumor Compounds

Journal of Medicinal Chemistry ◽

10.1021/jm970464g ◽

1997 ◽

Vol 40 (26) ◽

pp. 4290-4301 ◽

Cited By ~ 26

Author(s):

F. George Njoroge ◽

Bancha Vibulbhan ◽

Dinananth F. Rane ◽

W. Robert Bishop ◽

Joanne Petrin ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Design And Synthesis ◽

Structure Activity ◽

Antitumor Compounds ◽

Farnesyl Protein Transferase ◽

Relationship Of

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STRUCTURE-ACTIVITY RELATIONSHIP OF VARIOUS ANALOGUES OF β-CORTICOTRROPHIN DETERMINED BY REFERENCE TO VARIOUS PARAMETERS IN VITRO AND IN VIVO

Acta Endocrinologica ◽

10.1530/acta.0.061s029 ◽

1969 ◽

Vol 61 (1_Suppl) ◽

pp. S29

Author(s):

Pierre A. Desaulles ◽

René Maier ◽

Matthys Staehelin

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of

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Structure-Activity Relationship of AMP-Luciferin Analogs for In Vivo Imaging

ECS Meeting Abstracts ◽

10.1149/ma2016-02/45/3311 ◽

2016 ◽

Keyword(s):

In Vivo Imaging ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of

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Antifungal Spectrum, In Vivo Efficacy, and Structure–Activity Relationship of Ilicicolin H

ACS Medicinal Chemistry Letters ◽

10.1021/ml300173e ◽

2012 ◽

Vol 3 (10) ◽

pp. 814-817 ◽

Cited By ~ 17

Author(s):

Sheo B. Singh ◽

Weiguo Liu ◽

Xiaohua Li ◽

Tom Chen ◽

Ali Shafiee ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

In Vivo Efficacy ◽

Structure Activity ◽

Relationship Of

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Discovery and Structure−Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity in Vitro and in Vivo

Journal of Medicinal Chemistry ◽

10.1021/jm050754u ◽

2006 ◽

Vol 49 (3) ◽

pp. 1165-1181 ◽

Cited By ~ 94

Author(s):

Michael D. Wendt ◽

Wang Shen ◽

Aaron Kunzer ◽

William J. McClellan ◽

Milan Bruncko ◽

...

Keyword(s):

B Cell ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of

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Quantitative structure–activity relationship of spirosuccinimide type aldose reductase inhibitors diminishing sorbitol accumulation in vivo

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2005.12.019 ◽

2006 ◽

Vol 14 (9) ◽

pp. 3090-3097 ◽

Cited By ~ 6

Author(s):

Kwangseok Ko ◽

Hoshik Won ◽

Youngdo Won

Keyword(s):

Aldose Reductase ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Aldose Reductase Inhibitors ◽

Reductase Inhibitors ◽

Structure Activity ◽

Relationship Of

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Structure–Activity Relationship of the Epothilones and the First In Vivo Comparison with Paclitaxel

Angewandte Chemie International Edition in English ◽

10.1002/anie.199720931 ◽

1997 ◽

Vol 36 (19) ◽

pp. 2093-2096 ◽

Cited By ~ 80

Author(s):

Dai-Shi Su ◽

Aaron Balog ◽

Dongfang Meng ◽

Peter Bertinato ◽

Samuel J. Danishefsky ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of

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Pilot in Vivo Structure–Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O6-Methylguanine and Lung Tumor in A/J Mice

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b00921 ◽

2017 ◽

Vol 60 (18) ◽

pp. 7935-7940 ◽

Cited By ~ 7

Author(s):

Manohar Puppala ◽

Sreekanth C. Narayanapillai ◽

Pablo Leitzman ◽

Haifeng Sun ◽

Pramod Upadhyaya ◽

...

Keyword(s):

Lung Tumor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of

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Design, Synthesis, and Structure−Activity Relationship of Substrate Competitive, Selective, and in Vivo Active Triazole and Thiadiazole Inhibitors of the c-Jun N-Terminal Kinase

Journal of Medicinal Chemistry ◽

10.1021/jm801503n ◽

2009 ◽

Vol 52 (7) ◽

pp. 1943-1952 ◽

Cited By ~ 43

Author(s):

Surya K. De ◽

John L. Stebbins ◽

Li-Hsing Chen ◽

Megan Riel-Mehan ◽

Thomas Machleidt ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Of

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Synthesis and Structure—Activity Relationship of 4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazine Derivatives: Highly Potent and Selective AMPA Receptor Antagonists with in vivo Activity

ChemInform ◽

10.1002/chin.200451232 ◽

2004 ◽

Vol 35 (51) ◽

Author(s):

Jean-Marie Stutzmann ◽

Marc Vuilhorgne ◽

Serge Mignani

Keyword(s):

Ampa Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Antagonists ◽

Structure Activity ◽

Relationship Of

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Design and synthesis of cell potent BACE-1 inhibitors: Structure–activity relationship of P1′ substituents

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.09.061 ◽

2009 ◽

Vol 19 (22) ◽

pp. 6386-6391 ◽

Cited By ~ 24

Author(s):

Jennifer M. Sealy ◽

Anh P. Truong ◽

Luke Tso ◽

Gary D. Probst ◽

Jose Aquino ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Design And Synthesis ◽

Structure Activity ◽

Relationship Of ◽

Bace 1

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