scholarly journals Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1)

MedChemComm ◽  
2016 ◽  
Vol 7 (9) ◽  
pp. 1793-1796 ◽  
Author(s):  
H. Ü. Kaniskan ◽  
M. S. Eram ◽  
J. Liu ◽  
D. Smil ◽  
M. L. Martini ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
High Potency ◽  
Arginine Methyltransferase ◽  
Design And Synthesis ◽  
Structure Activity ◽  
Methyltransferase 1

Structure–activity relationship studies, starting from a fragment hit, resulted in discovery of the compound 9, an inhibitor of CARM1 with high potency and selectivity.

scholarly journals Discovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic β-Amyloid-42 Fibril Formation

2012 ◽  
Vol 287 (41) ◽  
pp. 34786-34800 ◽  
Author(s):  
Heiko Kroth ◽  
Annalisa Ansaloni ◽  
Yvan Varisco ◽  
Asad Jan ◽  
Nampally Sreenivasachary ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Structure Activity Relationship ◽  
Fibril Formation ◽  
Activity Relationship ◽  
Structure Activity ◽  
Β Amyloid ◽  
Relationship Of

Identification and Structure-Activity Relationship Studies of Small-Molecule Inhibitors of the Methyllysine Reader Protein Spindlin1

ChemMedChem ◽  
2016 ◽  
Vol 11 (20) ◽  
pp. 2327-2338 ◽  
Author(s):  
Dina Robaa ◽  
Tobias Wagner ◽  
Chiara Luise ◽  
Luca Carlino ◽  
Joel McMillan ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity

Structure–Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase

2017 ◽  
Vol 60 (12) ◽  
pp. 5015-5028 ◽  
Author(s):  
Harshini Neelakantan ◽  
Hua-Yu Wang ◽  
Virginia Vance ◽  
Jonathan D. Hommel ◽  
Stanton F. McHardy ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity

Identification and structure-activity relationship studies of small molecule inhibitors of the human cathepsin D

2021 ◽  
Vol 29 ◽  
pp. 115879
Author(s):  
Sandeep Goyal ◽  
Ketul V. Patel ◽  
Yadav Nagare ◽  
Digambar B. Raykar ◽  
Santosh S. Raikar ◽  
...  
Keyword(s):  
Small Molecule ◽  
Cathepsin D ◽  
Small Molecule Inhibitors ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Human Cathepsin

scholarly journals Structure–activity relationship studies of small-molecule inhibitors of Wnt response

2009 ◽  
Vol 19 (14) ◽  
pp. 3825-3827 ◽  
Author(s):  
Jianming Lu ◽  
Zhiqiang Ma ◽  
Jen-Chieh Hsieh ◽  
Chih-Wei Fan ◽  
Baozhi Chen ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity

A structure-activity relationship study of small-molecule inhibitors of GLI1-mediated transcription

Biopolymers ◽  
2010 ◽  
Vol 95 (1) ◽  
pp. 24-30 ◽  
Author(s):  
Marcelo Actis ◽  
Michele C. Connelly ◽  
Anand Mayasundari ◽  
Chandanamali Punchihewa ◽  
Naoaki Fujii
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Study
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