A Catalyst‐Free Cascade Reaction for the Selective Assembly of 3‐Hydroxyisoindolinones on Water

2019 ◽  
Vol 8 (11) ◽  
pp. 2073-2091 ◽  
Author(s):  
Pinyi Li ◽  
Xiuwen Jia ◽  
Xiaoli Ma ◽  
Wenbo Ma ◽  
Yilin Sheng ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Selective Assembly ◽  
Catalyst Free

scholarly journals Front Cover: A Catalyst‐Free Cascade Reaction for the Selective Assembly of 3‐Hydroxyisoindolinones on Water (Asian J. Org. Chem. 11/2019)

2019 ◽  
Vol 8 (11) ◽  
pp. 1948-1948
Author(s):  
Pinyi Li ◽  
Xiuwen Jia ◽  
Xiaoli Ma ◽  
Wenbo Ma ◽  
Yilin Sheng ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Selective Assembly ◽  
Front Cover ◽  
Catalyst Free

Catalyst-free facile synthesis of polycyclic indole/pyrrole substituted-1,2,3-triazoles

2019 ◽  
Vol 17 (35) ◽  
pp. 8153-8165 ◽  
Author(s):  
Jitendra Gour ◽  
Srikanth Gatadi ◽  
Ravikumar Akunuri ◽  
Madhavi Venkata Yaddanapudi ◽  
Mushtaq Ahmad Nengroo ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Free Access ◽  
Facile Synthesis ◽  
Reaction Conditions ◽  
Catalyst Free

A general and catalyst-free access to the fused polycyclic N-heterocycles via an intramolecular azide–alkene cascade reaction under mild reaction conditions has been developed.

Catalyst-Free Synthesis of Chromane-Type N,O-Acetals via Intramolecular Addition of Phenols to Enamines

Synthesis ◽  
2020 ◽  
Vol 52 (23) ◽  
pp. 3604-3621 ◽  
Author(s):  
Vitaly A. Osyanin ◽  
Dmitry V. Osipov ◽  
Irina V. Melnikova ◽  
Kirill S. Korzhenko ◽  
Irina A. Semenova ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Secondary Amines ◽  
Catalyst Free ◽  
Reaction Proceeds ◽  
New Strategy

A new strategy to 2-aminochromanes through catalyst-free cascade reaction of 3-trifluoroacetyl-4H-chromenes and 4H-chromene-3-carbaldehydes with cyclic secondary amines is presented. The reaction proceeds through subsequent 1,4- and 1,2-additions of amine, bimolecular elimination of trifluoroacetamide or formamide, and 6-exo-trig cyclization. The latter stage is a very rare example of addition of phenols to enamines. The obtained semicyclic N,O-acetals were applied as useful precursors for the synthesis of other chromanes.

ChemInform Abstract: Catalyst-Free Cascade Reaction of Heterocyclic Ketene Aminals with N-Substituted Maleimide to Synthesise Bicyclic Pyrrolidinone Derivatives.

ChemInform ◽  
2015 ◽  
Vol 46 (6) ◽  
pp. no-no
Author(s):  
Jin Liu ◽  
Hai-Rui Zhang ◽  
Xin-Rong Lin ◽  
Sheng-Jiao Yan ◽  
Jun Lin
Keyword(s):  
Cascade Reaction ◽  
Catalyst Free ◽  
Ketene Aminals

An Efficient Solvent- and Catalyst-Free Synthesis of Bicyclic Pyridones with High Molecular Diversity via Cascade Reaction

Heterocycles ◽  
2018 ◽  
Vol 96 (2) ◽  
pp. 311 ◽  
Author(s):  
Chao Huang ◽  
Wen-Rong Yang ◽  
Huang-Mei Fu ◽  
Hong-Bin Wang ◽  
Li-Juan Yang
Keyword(s):  
Molecular Diversity ◽  
Cascade Reaction ◽  
Catalyst Free

Catalyst-free synthesis of fused 1,2,3-triazole and isoindoline derivatives via an intramolecular azide–alkene cascade reaction

2017 ◽  
Vol 19 (3) ◽  
pp. 656-659 ◽  
Author(s):  
Yu-Yang Xie ◽  
Ying-Chun Wang ◽  
Yan He ◽  
Da-Chao Hu ◽  
Heng-Shan Wang ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Regioselective Synthesis ◽  
Catalyst Free

A simple and efficient methodology has been developed for the regioselective synthesis of fused 1,2,3-triazole and isoindoline derivatives under catalyst free conditions.

Synthesis of α-Amidoketones through the Cascade Reaction of Carboxylic Acids with Vinyl Azides under Catalyst-Free Conditions

2020 ◽  
Vol 85 (21) ◽  
pp. 13710-13720
Author(s):  
Cai Gao ◽  
Qianting Zhou ◽  
Li Yang ◽  
Xinying Zhang ◽  
Xuesen Fan
Keyword(s):  
Carboxylic Acids ◽  
Cascade Reaction ◽  
Catalyst Free ◽  
Vinyl Azides

Catalyst-free cascade reaction of heterocyclic ketene aminals with N-substituted maleimide to synthesise bicyclic pyrrolidinone derivatives

RSC Advances ◽  
2014 ◽  
Vol 4 (52) ◽  
pp. 27582-27590 ◽  
Author(s):  
Jin Liu ◽  
Hai-Rui Zhang ◽  
Xin-Rong Lin ◽  
Sheng-Jiao Yan ◽  
Jun Lin
Keyword(s):  
Environmentally Friendly ◽  
Cascade Reaction ◽  
Efficient Synthesis ◽  
Catalyst Free ◽  
Ketene Aminals

An efficient synthesis of bicyclic pyrrolidinones via a cascade reaction of HKAs and N-substituted maleimide in an environmentally friendly medium is described. This protocol uses group-assisted purification (GAP) chemistry. The library of bicyclic pyrrolidinone derivatives has been constructed with moderate to excellent yields.

Construction of a 4H-pyrido[4,3,2-gh]phenanthridin-5(6H)-one skeleton via a catalyst-free radical cascade addition/cyclization using azo compounds as radical sources

2018 ◽  
Vol 5 (5) ◽  
pp. 793-796 ◽  
Author(s):  
Chen Zhang ◽  
Junxia Pi ◽  
Shu Chen ◽  
Ping Liu ◽  
Peipei Sun
Keyword(s):  
Free Radical ◽  
Cascade Reaction ◽  
Radical Addition ◽  
Azo Compounds ◽  
Aromatic Substitution ◽  
Catalyst Free ◽  
Homolytic Aromatic Substitution ◽  
Radical Cascade

The new radical addition/cyano insertion/homolytic aromatic substitution cascade reaction initiated by the thermal homolysis of azo compounds under catalyst-free conditions produced polycyclic phenanthridine derivatives.

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