Synthesis of α-Amidoketones through the Cascade Reaction of Carboxylic Acids with Vinyl Azides under Catalyst-Free Conditions

2020 ◽  
Vol 85 (21) ◽  
pp. 13710-13720
Author(s):  
Cai Gao ◽  
Qianting Zhou ◽  
Li Yang ◽  
Xinying Zhang ◽  
Xuesen Fan
Keyword(s):  
Carboxylic Acids ◽  
Cascade Reaction ◽  
Catalyst Free ◽  
Vinyl Azides

Catalyst-free facile synthesis of polycyclic indole/pyrrole substituted-1,2,3-triazoles

2019 ◽  
Vol 17 (35) ◽  
pp. 8153-8165 ◽  
Author(s):  
Jitendra Gour ◽  
Srikanth Gatadi ◽  
Ravikumar Akunuri ◽  
Madhavi Venkata Yaddanapudi ◽  
Mushtaq Ahmad Nengroo ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Free Access ◽  
Facile Synthesis ◽  
Reaction Conditions ◽  
Catalyst Free

A general and catalyst-free access to the fused polycyclic N-heterocycles via an intramolecular azide–alkene cascade reaction under mild reaction conditions has been developed.

Catalyst-Free Synthesis of Chromane-Type N,O-Acetals via Intramolecular Addition of Phenols to Enamines

Synthesis ◽  
2020 ◽  
Vol 52 (23) ◽  
pp. 3604-3621 ◽  
Author(s):  
Vitaly A. Osyanin ◽  
Dmitry V. Osipov ◽  
Irina V. Melnikova ◽  
Kirill S. Korzhenko ◽  
Irina A. Semenova ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Secondary Amines ◽  
Catalyst Free ◽  
Reaction Proceeds ◽  
New Strategy

A new strategy to 2-aminochromanes through catalyst-free cascade reaction of 3-trifluoroacetyl-4H-chromenes and 4H-chromene-3-carbaldehydes with cyclic secondary amines is presented. The reaction proceeds through subsequent 1,4- and 1,2-additions of amine, bimolecular elimination of trifluoroacetamide or formamide, and 6-exo-trig cyclization. The latter stage is a very rare example of addition of phenols to enamines. The obtained semicyclic N,O-acetals were applied as useful precursors for the synthesis of other chromanes.

Thermo-Promoted Reactions of Anthranils with Carboxylic Acids, Amines, Phenols, and Malononitrile under Catalyst-Free Conditions

2019 ◽  
Vol 84 (4) ◽  
pp. 2022-2031 ◽  
Author(s):  
Jing Jiang ◽  
Xin Cai ◽  
Yanwei Hu ◽  
Xuejun Liu ◽  
Xiaodong Chen ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Catalyst Free

Catalyst-free tandem Michael addition/decarboxylation of (thio)coumarin-3-carboxylic acids with indoles: facile synthesis of indole-3-substituted 3,4-dihydro(thio)coumarins

2014 ◽  
Vol 12 (14) ◽  
pp. 2185-2188 ◽  
Author(s):  
Zhuzhou Shao ◽  
Lubin Xu ◽  
Liang Wang ◽  
Hongtao Wei ◽  
Jian Xiao
Keyword(s):  
Carboxylic Acids ◽  
Michael Addition ◽  
Facile Synthesis ◽  
Catalyst Free

The tandem Michael addition/decarboxylation of (thio)-coumarin-3-carboxylic acids with indoles gives biologically important indole-3-substituted dihydrocoumarins in good to excellent yields under catalyst-free conditions.

ChemInform Abstract: Catalyst-Free Cascade Reaction of Heterocyclic Ketene Aminals with N-Substituted Maleimide to Synthesise Bicyclic Pyrrolidinone Derivatives.

ChemInform ◽  
2015 ◽  
Vol 46 (6) ◽  
pp. no-no
Author(s):  
Jin Liu ◽  
Hai-Rui Zhang ◽  
Xin-Rong Lin ◽  
Sheng-Jiao Yan ◽  
Jun Lin
Keyword(s):  
Cascade Reaction ◽  
Catalyst Free ◽  
Ketene Aminals

Esterification of carboxylic acids by tributyl borate under solvent- and catalyst-free conditions

2005 ◽  
Vol 7 (12) ◽  
pp. 870 ◽  
Author(s):  
Yagoub Mansoori ◽  
Firdovsi Seyidov Tataroglu ◽  
Mitra Sadaghian
Keyword(s):  
Carboxylic Acids ◽  
Catalyst Free

ChemInform Abstract: Catalyst-Free Synthesis of 3-(Alkylamino)-2-arylimidazo[1,2-a]pyridine-8-carboxylic Acids via a Three-Component Condensation.

ChemInform ◽  
2014 ◽  
Vol 45 (45) ◽  
pp. no-no
Author(s):  
Ghasem Marandi ◽  
Lotfali Saghatforoush ◽  
Rafael Mendoza-Merono ◽  
Santiago Garcia-Granda
Keyword(s):  
Carboxylic Acids ◽  
Catalyst Free

Catalyst-free synthesis of 3-(alkylamino)-2-arylimidazo[1,2-a]pyridine-8-carboxylic acids via a three-component condensation

2014 ◽  
Vol 55 (19) ◽  
pp. 3052-3054 ◽  
Author(s):  
Ghasem Marandi ◽  
Lotfali Saghatforoush ◽  
Rafael Mendoza-Meroño ◽  
Santiago García-Granda
Keyword(s):  
Carboxylic Acids ◽  
Catalyst Free

An Efficient Solvent- and Catalyst-Free Synthesis of Bicyclic Pyridones with High Molecular Diversity via Cascade Reaction

Heterocycles ◽  
2018 ◽  
Vol 96 (2) ◽  
pp. 311 ◽  
Author(s):  
Chao Huang ◽  
Wen-Rong Yang ◽  
Huang-Mei Fu ◽  
Hong-Bin Wang ◽  
Li-Juan Yang
Keyword(s):  
Molecular Diversity ◽  
Cascade Reaction ◽  
Catalyst Free
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