ChemInform Abstract: Catalyst-Free Cascade Reaction of Heterocyclic Ketene Aminals with N-Substituted Maleimide to Synthesise Bicyclic Pyrrolidinone Derivatives.

ChemInform ◽  
2015 ◽  
Vol 46 (6) ◽  
pp. no-no
Author(s):  
Jin Liu ◽  
Hai-Rui Zhang ◽  
Xin-Rong Lin ◽  
Sheng-Jiao Yan ◽  
Jun Lin
Keyword(s):  
Cascade Reaction ◽  
Catalyst Free ◽  
Ketene Aminals

Catalyst-free cascade reaction of heterocyclic ketene aminals with N-substituted maleimide to synthesise bicyclic pyrrolidinone derivatives

RSC Advances ◽  
2014 ◽  
Vol 4 (52) ◽  
pp. 27582-27590 ◽  
Author(s):  
Jin Liu ◽  
Hai-Rui Zhang ◽  
Xin-Rong Lin ◽  
Sheng-Jiao Yan ◽  
Jun Lin
Keyword(s):  
Environmentally Friendly ◽  
Cascade Reaction ◽  
Efficient Synthesis ◽  
Catalyst Free ◽  
Ketene Aminals

An efficient synthesis of bicyclic pyrrolidinones via a cascade reaction of HKAs and N-substituted maleimide in an environmentally friendly medium is described. This protocol uses group-assisted purification (GAP) chemistry. The library of bicyclic pyrrolidinone derivatives has been constructed with moderate to excellent yields.

Catalyst-free facile synthesis of polycyclic indole/pyrrole substituted-1,2,3-triazoles

2019 ◽  
Vol 17 (35) ◽  
pp. 8153-8165 ◽  
Author(s):  
Jitendra Gour ◽  
Srikanth Gatadi ◽  
Ravikumar Akunuri ◽  
Madhavi Venkata Yaddanapudi ◽  
Mushtaq Ahmad Nengroo ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Free Access ◽  
Facile Synthesis ◽  
Reaction Conditions ◽  
Catalyst Free

A general and catalyst-free access to the fused polycyclic N-heterocycles via an intramolecular azide–alkene cascade reaction under mild reaction conditions has been developed.

Catalyst-Free Synthesis of Chromane-Type N,O-Acetals via Intramolecular Addition of Phenols to Enamines

Synthesis ◽  
2020 ◽  
Vol 52 (23) ◽  
pp. 3604-3621 ◽  
Author(s):  
Vitaly A. Osyanin ◽  
Dmitry V. Osipov ◽  
Irina V. Melnikova ◽  
Kirill S. Korzhenko ◽  
Irina A. Semenova ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Secondary Amines ◽  
Catalyst Free ◽  
Reaction Proceeds ◽  
New Strategy

A new strategy to 2-aminochromanes through catalyst-free cascade reaction of 3-trifluoroacetyl-4H-chromenes and 4H-chromene-3-carbaldehydes with cyclic secondary amines is presented. The reaction proceeds through subsequent 1,4- and 1,2-additions of amine, bimolecular elimination of trifluoroacetamide or formamide, and 6-exo-trig cyclization. The latter stage is a very rare example of addition of phenols to enamines. The obtained semicyclic N,O-acetals were applied as useful precursors for the synthesis of other chromanes.

An environmentally benign, mild, and catalyst-free reaction of quinones with heterocyclic ketene aminals in ethanol: site-selective synthesis of rarely fused [1,2-a]indolone derivatives via an unexpected anti-Nenitzescu strategy

2014 ◽  
Vol 16 (9) ◽  
pp. 4359-4370 ◽  
Author(s):  
Bei Zhou ◽  
Zhi-Cheng Liu ◽  
Wen-Wen Qu ◽  
Rui Yang ◽  
Xin-Rong Lin ◽  
...  
Keyword(s):  
Environmentally Benign ◽  
Selective Synthesis ◽  
Catalyst Free ◽  
Ketene Aminals ◽  
Site Selective

The first site-selective methodology for the construction of fused [1,2-a]indolone derivativesviaan unexpected anti-Nenitzescu strategy has been developed.

scholarly journals An efficient synthesis of new imidazo[1,2-a]pyridine-6-carbohydrazide and pyrido[1,2-a]pyrimidine-7-carbohydrazide derivatives via a five-component cascade reaction

RSC Advances ◽  
2019 ◽  
Vol 9 (13) ◽  
pp. 7218-7227 ◽  
Author(s):  
Hajar Hosseini ◽  
Mohammad Bayat
Keyword(s):  
Cascade Reaction ◽  
Efficient Synthesis ◽  
Ketene Aminals

An easy synthesis of novel and highly substituted imidazo[1,2-a]pyridines and pyrido[1,2-a]pyrimidines using heterocyclic ketene aminals.

ChemInform Abstract: Cascade Reaction of Isatins with Heterocyclic Ketene Aminals: Synthesis of Imidazopyrroloquinoline Derivatives.

ChemInform ◽  
2011 ◽  
Vol 43 (3) ◽  
pp. no-no
Author(s):  
Fuchao Yu ◽  
Shengjiao Yan ◽  
Ling Hu ◽  
Yongchao Wang ◽  
Jun Lin
Keyword(s):  
Cascade Reaction ◽  
Ketene Aminals

An Efficient Solvent- and Catalyst-Free Synthesis of Bicyclic Pyridones with High Molecular Diversity via Cascade Reaction

Heterocycles ◽  
2018 ◽  
Vol 96 (2) ◽  
pp. 311 ◽  
Author(s):  
Chao Huang ◽  
Wen-Rong Yang ◽  
Huang-Mei Fu ◽  
Hong-Bin Wang ◽  
Li-Juan Yang
Keyword(s):  
Molecular Diversity ◽  
Cascade Reaction ◽  
Catalyst Free

Catalyst-free synthesis of fused 1,2,3-triazole and isoindoline derivatives via an intramolecular azide–alkene cascade reaction

2017 ◽  
Vol 19 (3) ◽  
pp. 656-659 ◽  
Author(s):  
Yu-Yang Xie ◽  
Ying-Chun Wang ◽  
Yan He ◽  
Da-Chao Hu ◽  
Heng-Shan Wang ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Regioselective Synthesis ◽  
Catalyst Free

A simple and efficient methodology has been developed for the regioselective synthesis of fused 1,2,3-triazole and isoindoline derivatives under catalyst free conditions.

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