crooke’s hyalinization
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2020 ◽  
Vol 31 (2) ◽  
pp. 190-194
Author(s):  
Mingfei Yan ◽  
Kara L. Roncin ◽  
Scott Wilhelm ◽  
Jay K. Wasman ◽  
Sylvia L. Asa

2002 ◽  
Vol 13 (3) ◽  
pp. 245-249 ◽  
Author(s):  
Federico Roncaroli ◽  
Marco Faustini-Fustini ◽  
Francesco Mauri ◽  
Sofia Asioli ◽  
Giorgio Frank

1991 ◽  
Vol 2 (2) ◽  
pp. 111-116 ◽  
Author(s):  
Sebastiano Franscella ◽  
Charles-Abram Favrod-Coune ◽  
Gianpaolo Pizzolato ◽  
Sylvia L. Asa ◽  
Rolf Gaillard ◽  
...  

1991 ◽  
Vol 187 (5) ◽  
pp. 637-641 ◽  
Author(s):  
K. Kamijo ◽  
M. Sato ◽  
T. Saito ◽  
A. Yachi ◽  
T Minase ◽  
...  

Author(s):  
E. Horvath ◽  
K. Kovacs ◽  
L. Stefaneanu ◽  
N. Losinski

Human pituitary corticotropins have unique morphologic markers: bundles of type-1 filaments, measuring approximately 70 A in width and representing cytokeratin. The extreme ring-like accumulation of type-1 filaments, known as Crooke's hyalinization, signals functional suppression of the corticotropins and occurs in endogenous and exogenous glucocorticoid excess, caused by ACTH-secreting pituitary adenoma, glucocorticoid secreting adrenocortical tumor, ectopic ACTH-syndrome and administration of pharmacologic doses of glucocorticoids. Cells of autonomous corticotroph adenomas usually do not show Crooke's hyalin change. A minority of these tumors, however, retains sensitivity to the negative feed-back effect of elevated blood glucocorticoid levels and display typical Crooke’s change.In the present study pituitary corticotropins in various phases of Crooke's hyalinization were investigated in patients with glucocorticoid excess of various origin, applying histology, immunocytochemistry, count of argyrophilic nucleolar organizer regions (AgNOR), and transmission electron microscopy.


1981 ◽  
Vol 58 (3-4) ◽  
pp. 235-243 ◽  
Author(s):  
I. A. Felix ◽  
E. Horvath ◽  
K. Kovacs

PEDIATRICS ◽  
1971 ◽  
Vol 48 (2) ◽  
pp. 329-330
Author(s):  
N. S. Halmi ◽  
Gilbert S. Omenn

In Dr. Gilbert S. Omenn's1 otherwise excellent review of ectopic hormone syndromes associated with tumors in childhood we find the following sentence: "Completely characterized cases of ectopic ACTH syndrome have bilateral adrenal hyperplasia, normal pituitary basophils, positive assay for ACTH in the tumor, and failure of suppression of elevated plasma ACTH by dexamethasone." I have no personal experience with the ectopic ACTH syndrome in childhood, but in three cases seen in adults the basophils (more accurately, the ACTH-MSH cells among them), far from being normal, showed the expected profound Crooke's hyalinization characteristic of severe hypercortisolism.2


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