Crooke's Hyalinization in Silent Corticotroph Adenoma: Report of Two Cases

2002 ◽  
Vol 13 (3) ◽  
pp. 245-249 ◽  
Author(s):  
Federico Roncaroli ◽  
Marco Faustini-Fustini ◽  
Francesco Mauri ◽  
Sofia Asioli ◽  
Giorgio Frank
Keyword(s):  
Corticotroph Adenoma ◽  
Silent Corticotroph Adenoma ◽  
Crooke’S Hyalinization

Silent corticotroph adenoma: Experience with six cases

2020 ◽  
Author(s):  
Soler Guillermo Serra ◽  
Barceló Carlos Antich ◽  
Cubas Javier Bodoque ◽  
Fernández Honorato García ◽  
Bonet Antonio Mas ◽  
...  
Keyword(s):  
Corticotroph Adenoma ◽  
Silent Corticotroph Adenoma

scholarly journals Clinical Significance of Radical Surgery in the Treatment of Silent Corticotroph Adenoma

2019 ◽  
Vol 62 (1) ◽  
pp. 114-122 ◽  
Author(s):  
Junhyung Kim ◽  
Seon Jin Yoon ◽  
Ju Hyung Moon ◽  
Cheol Ryong Ku ◽  
Se Hoon Kim ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Radical Surgery ◽  
Corticotroph Adenoma ◽  
Silent Corticotroph Adenoma

scholarly journals A Case of Nonfunctioning Pituitary Adenoma Resembling So-called Silent Corticotroph Adenoma.

1997 ◽  
Vol 44 (2) ◽  
pp. 329-333 ◽  
Author(s):  
HIROMI SAKAGUCHI ◽  
HIROYUKI KOSHIYAMA ◽  
TOSHIAKI SANO ◽  
DAISUKE INOUE ◽  
NOBUO HASHIMOTO ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Nonfunctioning Pituitary Adenoma ◽  
Corticotroph Adenoma ◽  
Silent Corticotroph Adenoma

scholarly journals Postoperative expression of Cushing disease in a young male: metamorphosis of silent corticotroph adenoma?

2019 ◽  
Vol 2019 ◽  
Author(s):  
Sharmin Jahan ◽  
M A Hasanat ◽  
Tahseen Mahmood ◽  
Shahed Morshed ◽  
Raziul Haq ◽  
...  
Keyword(s):  
Cushing Syndrome ◽  
Young Male ◽  
List Type ◽  
Drug Induced ◽  
Blurred Vision ◽  
Diagnostic Dilemma ◽  
Cushing Disease ◽  
Repeat Surgery ◽  
Corticotroph Adenoma ◽  
Silent Corticotroph Adenoma

Summary Silent corticotroph adenoma (SCA) is an unusual type of nonfunctioning pituitary adenoma (NFA) that is silent both clinically and biochemically and can only be recognized by positive immunostaining for ACTH. Under rare circumstances, it can transform into hormonally active disease presenting with severe Cushing syndrome. It might often produce diagnostic dilemma with difficult management issue if not thoroughly investigated and subtyped accordingly following surgery. Here, we present a 21-year-old male who initially underwent pituitary adenomectomy for presumed NFA with compressive symptoms. However, he developed recurrent and invasive macroadenoma with severe clinical as well as biochemical hypercortisolism during post-surgical follow-up. Repeat pituitary surgery was carried out urgently as there was significant optic chiasmal compression. Immunohistochemical analysis of the tumor tissue obtained on repeat surgery proved it to be an aggressive corticotroph adenoma. Though not cured, he showed marked clinical and biochemical improvement in the immediate postoperative period. Anticipating recurrence from the residual tumor, we referred him for cyber knife radio surgery. Learning points: Pituitary NFA commonly present with compressive symptoms such as headache and blurred vision. Post-surgical development of Cushing syndrome in such a case could be either drug induced or endogenous. In the presence of recurrent pituitary tumor, ACTH-dependent Cushing syndrome indicates CD. Rarely a SCA presenting initially as NFA can transform into an active corticotroph adenoma. Immunohistochemical marker for ACTH in the resected tumor confirms the diagnosis.

scholarly journals A Whole Slide Image Managing Library Based on Fastai for Deep Learning in the Context of Histopathology: Two Use-Cases Explained

2021 ◽  
Author(s):  
Christoph Neuner ◽  
Roland Coras ◽  
Ingmar Blümcke ◽  
Alexander Popp ◽  
Sven M. Schlaffer ◽  
...  
Keyword(s):  
Area Under The Curve ◽  
Relevant Information ◽  
Use Cases ◽  
Dysembryoplastic Neuroepithelial Tumor ◽  
Low Grade ◽  
Corticotroph Adenoma ◽  
Slide Image ◽  
Silent Corticotroph Adenoma ◽  
Hematoxylin And Eosin ◽  
Pathological Disease

Background: Processing whole-slide images (WSI) to train neural networks can be intricate and laborious. We developed an open-source library covering recurrent tasks in processing of WSI and in evaluating the performance of the trained networks for classification tasks. Methods: Two histopathology use-cases were selected. First we aimed to train a CNN to distinguish H&E-stained slides obtained from neuropathologically classified low-grade epilepsy-associated dysembryoplastic neuroepithelial tumor (DNET) and ganglioglioma (GG). The second project we trained a convolutional neural network (CNN) to predict the hormone expression of pituitary adenoms only from hematoxylin and eosin (H&E) stained slides. In the same approach, we addressed the issue to also predict clinically silent corticotroph adenoma. We included four clinico-pathological disease conditions in a multilabel approach. Results: Our best performing CNN achieved an area under the curve (AUC) of 0.97 for the receiver operating characteristic (ROC) for corticotroph adenoma, 0.86 for silent corticotroph adenoma and 0.98 for gonadotroph adenoma. Our DNET-GG classifier achieved an AUC of 1.00 for the ROC curve. All scores were calculated with the help of our library on predictions on a case basis. Conclusions: Our comprehensive library is most helpful to standardize the work-flow and minimize the work-burden in training CNN. It is also compatible with fastai. Indeed, our new CNNs reliably extracted neuropathologically relevant information from the H&E staining only. This approach will supplement the clinico-pathological diagnosis of brain tumors, which is currently based on cost-intense microscopic examination and variable panels of immunohistochemical stainings.

scholarly journals Aggressive silent corticotroph adenoma progressing to pituitary carcinoma. The role of temozolomide therapy

HORMONES ◽  
2011 ◽  
Vol 10 (2) ◽  
pp. 162-167 ◽  
Author(s):  
Olga Moshkin ◽  
Luis Syro ◽  
Bernd Scheithauer ◽  
Leon Ortiz ◽  
Camilo Fadul ◽  
...  
Keyword(s):  
Pituitary Carcinoma ◽  
Corticotroph Adenoma ◽  
Silent Corticotroph Adenoma
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