Pituitary corticotroph adenoma with crooke’s hyalinization

1991 ◽  
Vol 2 (2) ◽  
pp. 111-116 ◽  
Author(s):  
Sebastiano Franscella ◽  
Charles-Abram Favrod-Coune ◽  
Gianpaolo Pizzolato ◽  
Sylvia L. Asa ◽  
Rolf Gaillard ◽  
...  
Keyword(s):  
Corticotroph Adenoma ◽  
Crooke’S Hyalinization

Crooke's Hyalinization in Silent Corticotroph Adenoma: Report of Two Cases

2002 ◽  
Vol 13 (3) ◽  
pp. 245-249 ◽  
Author(s):  
Federico Roncaroli ◽  
Marco Faustini-Fustini ◽  
Francesco Mauri ◽  
Sofia Asioli ◽  
Giorgio Frank
Keyword(s):  
Corticotroph Adenoma ◽  
Silent Corticotroph Adenoma ◽  
Crooke’S Hyalinization

Electron Microscopic investigation of crooke’s change in the pituitaries of patients with hypercorticism

1989 ◽  
Vol 47 ◽  
pp. 848-849
Author(s):  
E. Horvath ◽  
K. Kovacs ◽  
L. Stefaneanu ◽  
N. Losinski
Keyword(s):  
Nucleolar Organizer ◽  
Microscopic Investigation ◽  
Electron Microscopic Investigation ◽  
Ectopic Acth Syndrome ◽  
Nucleolar Organizer Regions ◽  
Electron Microscopic ◽  
Human Pituitary ◽  
Ectopic Acth ◽  
Crooke’S Hyalinization

Human pituitary corticotropins have unique morphologic markers: bundles of type-1 filaments, measuring approximately 70 A in width and representing cytokeratin. The extreme ring-like accumulation of type-1 filaments, known as Crooke's hyalinization, signals functional suppression of the corticotropins and occurs in endogenous and exogenous glucocorticoid excess, caused by ACTH-secreting pituitary adenoma, glucocorticoid secreting adrenocortical tumor, ectopic ACTH-syndrome and administration of pharmacologic doses of glucocorticoids. Cells of autonomous corticotroph adenomas usually do not show Crooke's hyalin change. A minority of these tumors, however, retains sensitivity to the negative feed-back effect of elevated blood glucocorticoid levels and display typical Crooke’s change.In the present study pituitary corticotropins in various phases of Crooke's hyalinization were investigated in patients with glucocorticoid excess of various origin, applying histology, immunocytochemistry, count of argyrophilic nucleolar organizer regions (AgNOR), and transmission electron microscopy.

Silent corticotroph adenoma: Experience with six cases

2020 ◽  
Author(s):  
Soler Guillermo Serra ◽  
Barceló Carlos Antich ◽  
Cubas Javier Bodoque ◽  
Fernández Honorato García ◽  
Bonet Antonio Mas ◽  
...  
Keyword(s):  
Corticotroph Adenoma ◽  
Silent Corticotroph Adenoma

Pituitary Adenomas that Produce Adrenocorticotropic Hormone and A-Subunit: Clinicopathological, Immunohistochemical, Ultrastructural, and Immunoelectron Microscopic Studies in Nine Cases

Neurosurgery ◽  
1990 ◽  
Vol 26 (3) ◽  
pp. 397-403 ◽  
Author(s):  
Kathryn K. Berg ◽  
Bernd W. Scheithauer ◽  
Ignacio Felix ◽  
Kalman Kovacs ◽  
Eva Horvath ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Adrenocorticotropic Hormone ◽  
Secretory Granules ◽  
Preoperative Evaluation ◽  
Periodic Acid ◽  
Periodic Acid Schiff ◽  
Double Labeling ◽  
Corticotroph Adenoma ◽  
A Subunit ◽  
Corticotroph Adenomas

Abstract Eight surgical and one autopsy specimen of pituitary adenomas (six cases of Cushing's disease, two of Nelson's syndrome. and one of hypopituitarism) were studied by histochemical, immunohistocytological, and ultrastructural methods. Eight tumors showed the characteristic histochemical profile of corticotroph adenoma—amphophilic to basophilic, and periodic acid-Schiff-positive to some extent. In all tumors, immunohistochemical studies revealed adrenocorticotropic hormone (ACTH) and à-subunit in the cytoplasm of some adenoma cells. By electron microscopy, seven tumors were found to be monomorphous; six were typical corticotroph adenomas and one was a subtype II silent corticotroph adenoma. One unique lesion was bimorphous—i.e., composed of corticotrophs as well as cells resembling glycoprotein cells. Immunoelectron microscopy by the double-labeling immunogold technique, performed on one corticotroph adenoma, demonstrated the presence of ACTH and à-subunit not only within the same adenoma cells but also within the same secretory granules. The cytogenesis of ACTH à-subunit tumors, a rare form of plurihormonal adenoma. remains to be elucidated. The duration of disease associated with these tumors exceeded the duration in patients with ordinary corticotroph adenomas. Given the low frequency with which increases in serum à-subunit are detectable in patients with such tumors—13% in this series—hormone production is not recognized at preoperative evaluation.

scholarly journals Clinical Significance of Radical Surgery in the Treatment of Silent Corticotroph Adenoma

2019 ◽  
Vol 62 (1) ◽  
pp. 114-122 ◽  
Author(s):  
Junhyung Kim ◽  
Seon Jin Yoon ◽  
Ju Hyung Moon ◽  
Cheol Ryong Ku ◽  
Se Hoon Kim ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Radical Surgery ◽  
Corticotroph Adenoma ◽  
Silent Corticotroph Adenoma

scholarly journals A Case of Nonfunctioning Pituitary Adenoma Resembling So-called Silent Corticotroph Adenoma.

1997 ◽  
Vol 44 (2) ◽  
pp. 329-333 ◽  
Author(s):  
HIROMI SAKAGUCHI ◽  
HIROYUKI KOSHIYAMA ◽  
TOSHIAKI SANO ◽  
DAISUKE INOUE ◽  
NOBUO HASHIMOTO ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Nonfunctioning Pituitary Adenoma ◽  
Corticotroph Adenoma ◽  
Silent Corticotroph Adenoma
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