Parametric Characterization of a Taste Phenotype in Rats Selectively Bred for High Versus Low Saccharin Intake

Taste signals food quality and reflects energy status and associated processes. Occidental high- and low-saccharin consuming rats (HiS, LoS) have been selectively bred for nearly 60 generations on intake of 0.1% saccharin in a 23-h two-bottle test, as a tool for studying individual differences in taste and its correlates in the domains of feeding, defensive, and social behavior. The saccharin phenotype itself has not been well characterized until now. The present series of parametric studies examined suprathreshold saccharin concentration-intake functions (Experiment 1), saccharin preference threshold (Experiments 2A and 2B), and intra- and inter-sweetener carryforward effects (Experiments 2B, 3A–3D). Results indicate high stability in line differences in behavior toward saccharin and also line-specific mutability of intake of saccharin and certain other sweeteners. Methodological and conceptual implications are discussed.

A potential sex dimorphism in the relationship between bitter taste and alcohol consumption

Sex-specific interactions between bitter taste phenotype, TAS2R38 genotype and alcohol intake may explain variance is previous studies, and may have implications for disease risk.