A NIR rhodamine fluorescent chemodosimeter specific for glutathione: Knoevenagel condensation, detection of intracellular glutathione and living cell imaging

A new near-infrared probe for detecting glutathione based on conjugate addition and intramolecular amino induced spirolactam opening named RhAN was designed and synthesized. Its emission intensity enhance more than 90-fold upon addition of GSH. In addition, it also has high sensitivity with low detection limit of 0.1 μM.

A NIR facile, cell-compatible fluorescent sensor for glutathione based on Michael addition induced cascade spirolactam opening and its application in hepatocellular carcinoma

A NIR fluorescence probe with NIR emission wavelength at 746 nm and high quantum yield of 0.36 was designed and synthesized to selectively detect GSH over Hcy and Cys in living systems.