noradrenaline administration
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2018 ◽  
Vol 35 (9) ◽  
pp. 641-649 ◽  
Author(s):  
Marc A. Furrer ◽  
Marc P. Schneider ◽  
Lukas M. Löffel ◽  
Fiona C. Burkhard ◽  
Patrick Y. Wuethrich

2014 ◽  
Vol 59 (2) ◽  
pp. 197-204 ◽  
Author(s):  
S. GENAY ◽  
B. DÉCAUDIN ◽  
S. SCOCCIA ◽  
C. BARTHÉLÉMY ◽  
B. DEBAENE ◽  
...  

1992 ◽  
Vol 15 (9) ◽  
pp. 660-665 ◽  
Author(s):  
M. I. Popovich ◽  
V. A. Kobets ◽  
S. I. Kostin ◽  
V. I. Kapelko

1992 ◽  
Vol 18 (7) ◽  
pp. 433-436 ◽  
Author(s):  
M. A. Hayes ◽  
E. H. S. Yau ◽  
C. J. Hinds ◽  
J. D. Watson

1984 ◽  
Vol 4 (4) ◽  
pp. 343-349 ◽  
Author(s):  
A. G. Duloo ◽  
D. S. Miller

The thermogenic response to noradrenaline administration was investigated at 25° in two models of obese mice (genetic ob/ob obesity of the ‘QEC’ strain and monosodium-glutamate-induced obesity) and in their respective lean littermates. Subcutaneous injections of a low dose of noradrenaline (I00 μg/kg body wt.) eJevated metabolic rate by about 3096 in both obese models but not in their respective lean counterparts. In contrast, the increase in metabolic rate after injections of a high dose of noradrenaline (600 μg/kg body wt.) was of a similar magnitude in both lean and obese animals: metabolic rate was increased by 70–80%. These results indicate that the overall whole body thermogenic capacity is unimpaired at room temperature in this ‘QEC’ strain of ob/ob mice and in the hypothalamic damaged obese mice. Obesity in these models is therefore not associated with a reduced ability to respond to noradrenaline but could rather be due to a failure to release noradrenaline.


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