Evaluation of the Psychometric Properties of the Swiss French Version of Older People’s Quality Of Life Questionnaire (OPQOL-35-SF)

Background: The proportion of older people aged more than 65 years old is continuously increasing in the world population. The quality of life is an important factor in their biopsychosocial handling. The questionnaire “Older People’s Quality of Life-35” (OPQOL-35) has been specially developed for the assessment of the senior’s quality of life. The aim of this study is to translate and evaluate the psychometric properties of the transcultural Swiss French version of the OPQOL-35 questionnaire (OPQOL-35-SF). Method: Forward-backward procedure was applied to translate the original questionnaire from English into Swiss French. Then, a sample of older people completed the questionnaire. The construct validity was evaluated by comparing the results of the OPQOL-35-SF with the scores of three other questionnaires (WHOQOL-OLD, CASP-12 and EQ-5D-5L) and two visual analogue scales (health and quality of life). The questionnaire’s structure has been assessed through exploratory and confirmatory factor analysis. The OPQOL-35-SF questionnaire was submitted a second time after 7 to 23 days to evaluate the reliability. Results: 264 older people completed all the questionnaires once and 262 the OPQOL-35-SF a second time. The mean age of participants was 76.8 (SD = 7.1). Most of them were women (73,9%). KMO is of 0.86 and the Bartlett’s test of sphericity is significant (p<0.001). The result of EFA shows 8 factors with eigenvalues greater than one, which explained 58% of the observed variance. All the items have a significant impact (<0.30) in at least one factor. The convergent validity presents low to moderate correlations (rho: 0.384-0.663). Internal consistency is good with a Cronbach’s alpha at 0.875 for test and at 0.902 for retest. Test-retest reliability presents an ICC2.1 at 0.83 (IC 0.78 to 0.87). Conclusion: The Swiss French version of the questionnaire OPQOL-35 shows psychometric properties which permit its use in the clinical practice or for research purposes. A supplementary sample would be necessary for a better repartition of the items in the different factors.

Determination of Turkish Norms of Psychometric Tests For Diagnosing Minimal Hepatic Encephalopathy and Proposal of a Simplified Paper Pencil Test Battery

Background: Psychometric hepatic encephalopathy score (PHES) needs standardization for countries and is used for minimal hepatic encephalopathy (mHE) diagnosis. Assessing it is cumbersome.Aims: To standardize PHES for Turkish patients and compare it with German norms; to determine mHE prevalence with two different methods and to assess whether the PHES test can be simplified.Methods: Healthy volunteers (n=816; 400 male) and cirrhotics (n=124; 58 male) were included. PHES score threshold was set at ≤-5 points and that of critical flicker frequency (CFF) at <39 Hz for mHE diagnosis. For comparing German and Turkish norms, datasets were combined. Multiple backward procedure was applied. Receiver operating characteristic (ROC) curves were created for assessing diagnostic capabilities of single subtests of the PHES test. Results: Turkish norms displayed non-linear dependence on age and education. Rate of mHE in compensated cirrhotics was 29.8% and 27.4% with PHES and CFF tests, respectively. Compatibility of two tests was low (kappa coefficient 0.389); mHE prevalence decreased to 16% when both tests were combined. Turks performed worse vs Germans in the digit symbol (DS) and serial dotting (SD) subtests but generally performed better in the other subtests. In ROC analyzes of subtests, AUROC was 0.974 for DS+SD tests combined. Conclusions: PHES norms for Turks were developed. Use of 2 methods for diagnosing mHE may be important for research purposes. From a clinical perspective sensitivity with acceptable specificity may suffice. Combined use of DS and SD subtests of the PHES battery may well be suited for use in clinical practice.

Translation and validation of core bereavement items into Urdu language on a sample of bereaved parents and spouses in Pakistan - pilot study

Core Bereavement Items Scale was translated into Urdu language and validated in Pakistani population through forward-backward procedure. It is 17-item scale with three subscales namely Images and thoughts; Acute Separation; and Grief. It was cross-sectional study commenced on 10th of June, 2016 and completed by July, 2017 as part of pilot study of PhD research at National Institute of Psychology, Quaid-I-Azam University, Islamabad. Sample of 260 participants was selected through a combination of convenience and snowball techniques. Results showed good alpha reliability and Item-total correlation ranged from 0.62 to 0.77. Confirmatory factor analysis showed good fit of the model on the data. Findings supported the three factor solution. The findings also indicated that female gender and people living in nuclear family system report more severe bereavement. Continuous...

Psychometric properties of the Iranian version of self-care ability scale for the elderly

Background Measuring self-care ability in elderly people needs specific instruments. The Self-care Ability Scale for Elderly (SASE) is one of the common instruments used for assessing self-care ability. The aim of this study was to assess the psychometric properties of the SASE among Iranian elderly population. Methods This cross-cultural adaptation study was carried out at Shahid Chamran and Shadpour Health Complex in Tabriz, Iran. The forward-backward procedure was applied to translate the SASE from English into Persian. Then, it was completed to 220 elderly people. A systematic random sampling method was used for sampling. Content validity was calculated through modified Kappa coefficient (modified CVI) based on clarity and relevance criteria. Reliability was measured by internal consistency and test-retest analysis. The construct validity also was assessed using Exploratory Factor Analysis (EFA). All the statistical analyses were performed using SPSS 21 statistical software package. Results The mean of self-care ability was 61.14 ± 21.08. The CVI and modified kappa were 0.91 and 0.92 for relevance and clarity, respectively. The Cronbach’s alpha coefficient was 0.73 and Intra-class correlation coefficient was 0.97. The results of EFA revealed a three-factor solution (‘ability to take care of personal responsibility’, ‘ability to take care for the goals’, and ‘ability to take care of the health’) that jointly explained for 64.61% of the total variance. Conclusion Results of the study showed that the Iranian version of the SASE has good psychometric properties and can be used in assessing the self-care ability of elderly people.

Development of the Chinese Version of Medication Adherence Reasons Scale (ChMAR-Scale)

Medication non-adherence is a concern in chronic disease management. Currently, there is no scale that characterizes sufficient non-adherent reasons for practical use in the Chinese population. This study developed and validated the Chinese version of the Medication Adherence Reasons Scale (ChMAR-Scale) and described non-adherence reasons in adult patients taking blood pressure medicine in Taiwan. A forward–backward procedure was used to translate the original MAR-Scale, and new items pertinent to cultural differences were added. Patients aged above 20 years old who were taking blood pressure medicine were recruited from a regional hospital and eight community pharmacies in the Taipei metropolitan area. Data analyses were conducted with IBM SPSS 19 (Armonk, NY, USA). Exploratory factor analysis revealed six domains, including belief, self-perception, forgetfulness, management, availability, and miscellaneous issues, with Cronbach’s alphas ranging from 0.649 to 0.852, item-total correlations ranging from 0.362 to 0.719, and factor loadings ranging from 0.365 to 0.775. Criterion-related validity with the visual analog scale and two global items were 0.525, 0.436, and 0.502. Forgetfulness, belief issues, and self-perception issues were the most common non-adherence reasons. In conclusion, the ChMAR-Scale showed good psychometric properties and identified more reasons for medication non-adherence than other existing scales. Healthcare providers should be vigilant of these problems while consulting patients.

The Ankylosing Spondylitis Performance Index: Reliability and Feasibility of an Objective Test for Physical Functioning

ObjectivePhysical function in patients with axial spondyloarthritis (axSpA) is currently evaluated through questionnaires. The Ankylosing Spondylitis Performance Index (ASPI) is a performance-based measure for physical functioning, which has been validated in Dutch patients with radiographic (r−) axSpA. The interrater reliability has not yet been determined. To our knowledge, this study is the first to evaluate the validity, reliability, and feasibility of the ASPI in another patient population, including both r− and nonradiographic (nr−) axSpA patients.MethodsPatients with axSpA were recruited from rheumatology clinics in Santiago, Chile. Dutch instructions were translated to Spanish by a forward-backward procedure. Study visits were performed at baseline and 1–4 weeks later. Four ASPI observers were involved, measuring the performance times of the 3 ASPI tests. Validity was assessed through a patient questionnaire (numeric rating scale 0–10: ≥ 6 sufficient). For reliability, intraclass correlation coefficients (ICC) were calculated (with 95% CI). Correlations between the ASPI and disease variables were tested with regression analyses.ResultsSixty-eight patients were included (57% male, 52% r-axSpA). All patients understood the Spanish instructions and considered the ASPI to reach its aim (84%) and representativeness (85%) for physical functioning. The overall interrater (n = 62) and test-retest (n = 39) reliability (ICC) of the 3 tests combined were 0.93 (0.88–0.96) and 0.94 (0.87–0.97), respectively. Eighty-two percent of the patients completed all tests and 94% finished in < 15 min (feasibility).ConclusionThis study demonstrated a high validity and feasibility in an entirely different population, with both r-axSpA and nr-axSpA. The interrater and test-retest reliability was excellent. The ASPI instructions are now available for Spanish-speaking patients.

The Persian short form Aging Perceptions Questionnaire (APQ-P): A validation study

Background Population aging is an important phenomenon for many countries worldwide. Considering the growing trend of aging population in Iran, it is very important to consider beliefs and perceptions of old people about aging. The Aging Perception Questionnaire (APQ) is one of the most common instruments that used to measure aging comprehension. The present study was a methodological inquiry that aimed to examine validity and reliability of the Persian version of the Aging Perception Questionnaire (APQ). Methods Forward-backward procedure was used for translation. Content validity and face validity were evaluated qualitatively. In order to evaluate construct validity a cross section study was conducted and both exploratory and confirmatory factor analyses were performed. In order to determine reliability, internal consistency (the Cronbach’s alpha) and stability (Intraclass Correlation Coefficient -ICC) were estimated. Results A total of 500 elderly people attending the community centers in Tehran, Iran were entered in other study and completed the Persian version of the questionnaire. Most elderly were female (52.8%).The mean age of participants was 68.33 (SD ± 6.10) years. The results obtained from exploratory factor analysis showed a four-factors solution (consequences negative, emotional representation, control positive and consequences positive) that jointly explained 52.8% of the total variance observed. In addition the confirmatory factory analysis showed a good fit for the data. Finally, the Cronbach’s alpha coefficient of 0.83 ranging from 0.80 to 0.87 was obtained for the whole scale and the subscales. The ICC value of 0.96 ranging from 0.90 to 0.98 was found for the whole scale and the subscales. Conclusion The results indicated that the Persian version of APQ is valid and can be used to measure aging perception in Iran.

Identification of Interfunctional Coordination Items Important for Business Performance of SMEs

This paper provides a deeper analysis of the relationships between interfunctional coordination (IFC) and business performance (BP). IFC is studied in many fields such as marketing, management, logistics, informatics or human resources. The novelty lies in offering an original perspective on IFC and its impact on individual items of BP. The statistical analysis of the relationship between IFC and BP is based on a survey of small and medium-sized manufacturers. Sufficient models were identified by a stepwise backward procedure based on Akaike information criterion (AIC). The results show that it is possible to find a sufficient model for each item of BP. Sets of IFC items with exclusively positive or negative influence on at least two BP items were identified. These items of IFC are aimed on cooperative arrangement, expertise, leadership style, coordination activities and control. This research brings theoretical contributions and can be useful for managers.

1558. A Population Pharmacokinetic Model for Posaconazole Intravenous Solution and Oral Powder for Suspension Formulations in Pediatric Patients With Neutropenia

Background Posaconazole is approved in adults for prophylaxis and treatment of invasive fungal disease. Two formulations that offer weight-based dosing—intravenous (IV) and oral powder for suspension (PFS)—are being evaluated in children. A population pharmacokinetic (popPK) approach was used to characterize and predict the PK exposure of posaconazole PFS and IV formulations in children to identify dosages associated with achieving a target PK of 1200 ng/mL as the mean Cavg and individual Cavg ≥500 ng/mL and <2500 ng/mL in ~90% of patients. Methods A popPK model was developed through nonlinear mixed-effects modeling using data obtained from a trial in children with neutropenia (ClinicalTrials.gov, NCT02452034; Merck protocol, MK-5592-097). Three dose cohorts (3.5, 4.5, and 6 mg/kg/day [≤300 mg/day]) were studied in two age groups (2–<7 years and 7–17 years). Posaconazole IV was administered twice on day 1 then once daily through at least day 10, followed by PFS once daily through day 28 at clinician discretion. A compartmental model, including both formulations, was fit to the data. Model selection was based on the Log-Likelihood Criterion, goodness-of-fit plots, and scientific plausibility. Significance of the covariates was assessed in a stepwise forward inclusion/backward procedure. An additional assessment characterized the impact of different food covariates on bioavailability. Results An open one-compartmental PK model with first-order absorption and estimated bioavailability, as well as allometrically scaled effects of body weight on clearance and volume, adequately described the PK of posaconazole IV and PFS formulations. Model predictions are shown in the Table. Effects of the different food covariates were not statistically significant. Simulations indicated that for the 6-mg/kg/d dose, model-predicted Cavg generally met PK targets. Model-predicted Cavg was ≥500 ng/mL in >90% of subjects in all cohorts. The 1200-ng/mL target geometric mean Cavg was achieved for all but the 2–<7 years cohort receiving the PFS formulation. Conclusion This popPK-based analysis demonstrated that the 6-mg/kg/d dose of IV or PFS posaconazole formulation (≤300 mg/days) is appropriate for children (2–17 years) and that PFS can be administered without regard to food. Disclosures All authors: No reported disclosures.