Doege-Potter syndrome due to endothoracic solitary hypoglycemic fibrous tumor

Doege-Potter syndrome leads to severe and sustained symptomatic hypoglycemia and is associated with the solitary fibrous tumor. It is a rare cause and its diagnosis requires a clinical suspicion and other markers such as insulin-like growth factor-II. Here, we describe a case of a patient with intrathoracic tumor and hypoglycemia

Doege-Potter syndrome due to endothoracic solitary hypoglycemic fibrous tumor

Doege-Potter syndrome leads to severe and sustained symptomatic hypoglycemia and is associated with the solitary fibrous tumor. It is a rare cause and its diagnosis requires a clinical suspicion and other markers such as insulin-like growth factor-II. Here, we describe a case of a patient with intrathoracic tumor and hypoglycemia

Transmission of Synovial Sarcoma from A Single Multiorgan Donor to Three Transplant Recipients: Cases Report and Literature Review

Background Donor-derived malignancy is sometimes unidentified at the time of transplantation, resulting in unanticipated donor-derived malignancy, which becomes a notable problem since the increasing use of marginal donors. Case presentation We first report three cases of donor-derived synovial sarcoma from a single multiorgan donor in China. The donor was died of respiratory failure caused by an intrathoracic tumor, which was diagnosed as a benign tumor at the time of donation. All of the three recipients developed synovial sarcoma within 3 months to 13 months after transplantation, proven to be donor-derived. Liver transplant recipient died of tumor metastasis. Two kidney transplant recipients survived from metastases by comprehensive therapy, including the first use of Anlotinib, exhibiting an effective anti-tumor activity.Conclusions This report highlights the importance of detailed donor assessment, close follow-up and timely treatment, as well as the need for establishing a post-transplant surveillance system for donor-derived transmission events. Whether to use organs from a donor with initial diagnosis of benign tumor needs to be cautious. Malignant potential of tumors needs to be excluded before transplantation, otherwise, the organs should be discarded.

Spine Metastasis of Thymic Carcinoma in a Pediatric Patient: A Case Report and Comprehensive Literature Review

<b><i>Introduction:</i></b> Thymic carcinoma metastases of the spinal column are very rare, especially in pediatric patients. To our knowledge, this is the first such pediatric case in the literature. <b><i>Case Presentation:</i></b> We report the case of a 14-year-old male patient with T12 and L1 metastases of thymic carcinoma. He had history of thymectomy and intrathoracic tumor resection 7 months previously. The patient’s neurological condition deteriorated; therefore, tumor resection and decompression of the spinal canal were performed. He underwent instrumentation and fusion procedures to prevent spinal instability. <b><i>Conclusion:</i></b> The main purpose of the treatment is gross total resection of the thymic carcinoma. However, adjuvant methods such as radiotherapy and chemotherapy should be added to the treatment protocol in patients who have higher stage diseases or those in whom total tumor resection cannot be achieved.