scholarly journals Persisting Cough as the Single Presenting Symptom of an Intrathoracic Tumor in a Nine-Month-Old Child with Adenovirus Airway Infection

2015 ◽  
Vol 2 (5) ◽  
Author(s):  
Wiegering V ◽  
Schlegel PG ◽  
Winkler B ◽  
Lazarus M ◽  
Wirth C ◽  
...  
Keyword(s):  
Airway Infection ◽  
Intrathoracic Tumor

Anti-Pseudomonas aeruginosa IgG Antibodies and Chronic Airway Infection in Non-Cystic Fibrosis Bronchiectasis

Pneumologie ◽  
2016 ◽  
Vol 70 (10) ◽  
Author(s):  
G Suarez-Cuartin ◽  
O Sibila ◽  
A Smith ◽  
H Abo-Leyah ◽  
A Rodrigo-Troyano ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Igg Antibodies ◽  
Airway Infection ◽  
Chronic Airway

scholarly journals AIRWAY INFECTION

1998 ◽  
Vol 12 (3) ◽  
pp. 671-688 ◽  
Author(s):  
Mitra Niroumand ◽  
Ronald F. Grossman
Keyword(s):  
Airway Infection

Removal of a Large Intrathoracic Tumor in a Child

1992 ◽  
Vol 74 (3) ◽  
pp. 460???463 ◽  
Author(s):  
Michael P. Hosking ◽  
Paul D. Mongan ◽  
Richard E. Peterson
Keyword(s):  
Intrathoracic Tumor

SPLUNC1 is a novel marker of disease severity and airway infection in bronchiectasis

2021 ◽  
pp. 2101840
Author(s):  
Holly R. Keir ◽  
Amelia Shoemark ◽  
Jeffrey T.J. Huang ◽  
James D. Chalmers
Keyword(s):  
Disease Severity ◽  
Airway Infection

scholarly journals Interrelationship between Dendritic Cell Trafficking and Francisella tularensis Dissemination following Airway Infection

2008 ◽  
Vol 4 (11) ◽  
pp. e1000211 ◽  
Author(s):  
Erez Bar-Haim ◽  
Orit Gat ◽  
Gal Markel ◽  
Hila Cohen ◽  
Avigdor Shafferman ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Francisella Tularensis ◽  
Cell Trafficking ◽  
Airway Infection ◽  
Dendritic Cell Trafficking

scholarly journals Using the Electronic Nose to Identify Airway Infection during COPD Exacerbations

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0135199 ◽  
Author(s):  
Hanaa Shafiek ◽  
Federico Fiorentino ◽  
Jose Luis Merino ◽  
Carla López ◽  
Antonio Oliver ◽  
...  
Keyword(s):  
Electronic Nose ◽  
Airway Infection ◽  
Copd Exacerbations

scholarly journals A point-of-care neutrophil elastase activity assay identifies bronchiectasis severity, airway infection and risk of exacerbation

2019 ◽  
Vol 53 (6) ◽  
pp. 1900303 ◽  
Author(s):  
Amelia Shoemark ◽  
Erin Cant ◽  
Luis Carreto ◽  
Alexandria Smith ◽  
Martina Oriano ◽  
...  
Keyword(s):  
Neutrophil Elastase ◽  
Point Of Care ◽  
Severity Index ◽  
Forced Expiratory Volume ◽  
Lateral Flow ◽  
Elastase Activity ◽  
Lateral Flow Device ◽  
Airway Infection ◽  
Independent Validation ◽  
Flow Device

IntroductionNeutrophil elastase activity in sputum can identify patients at high risk of airway infection and exacerbations in bronchiectasis. Application of this biomarker in clinical practice is limited, because no point-of-care test is available. We tested whether a novel semi-quantitative lateral flow device (neutrophil elastase airway test stick – NEATstik®) can stratify bronchiectasis patients according to severity, airway infection and exacerbation risk.MethodsSputum samples from 124 patients with stable bronchiectasis enrolled in the UK and Spain were tested using the NEATstik®, which scores neutrophil elastase concentration from 0 (<8 µg·mL−1 elastase activity) to 10 (maximum detectable neutrophil elastase activity). High neutrophil elastase activity was regarded as a NEATstik® grade >6. Severity of disease, airway infection from sputum culture and exacerbations over the 12 months were recorded. An independent validation was conducted in 50 patients from Milan, Italy.Measurements and main resultsPatients had a median age of 69 years and forced expiratory volume in 1 s (FEV1) 69%. High neutrophil elastase activity was associated with worse bronchiectasis severity using the bronchiectasis severity index (p=0.0007) and FEV1 (p=0.02). A high NEATstik® grade was associated with a significant increase in exacerbation frequency, incident rate ratio 2.75 (95% CI 1.63–4.64, p<0.001). The median time to next exacerbation for patients with a NEATstik® grade >6 was 103 days compared to 278 days. The hazard ratio was 2.59 (95% CI 1.71–3.94, p<0.001). Results were confirmed in the independent validation cohort.ConclusionsA novel lateral flow device provides assessment of neutrophil elastase activity from sputum in minutes and identifies patients at increasing risk of airway infection and future exacerbations.

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