Tuning the properties of a cyclic RGD-containing tetrapeptide through backbone fluorination

Fluorination alters a cyclic peptide's synthetic efficiency, its molecular conformation, and its biological activity.

Consecutive multicomponent reactions for the synthesis of complex molecules

Consecutive multicomponent reactions (MCRs) combine two or more MCRs to achieve high synthetic efficiency, product structural diversity, and molecular complexity.

A new and informative [a,b,c,d] nomenclature for one-pot multistep transformations: a simple tool to measure synthetic efficiency

We propose a generalized and informative [a,b,c,d] nomenclature for various types of one-pot multistep reactions, which emphasizes the fundamental parameters that define the synthetic efficiency of such transformations.

Enabling strategies for step efficient syntheses

The field of natural product total synthesis has reached the point where synthetic efficiency has become more important than merely defining a viable (yet less ideal) route to the target molecule. Several synthesis of different types of natural products are compared using color-coded flow charts.