scholarly journals A new and informative [a,b,c,d] nomenclature for one-pot multistep transformations: a simple tool to measure synthetic efficiency

RSC Advances ◽  
2018 ◽  
Vol 8 (38) ◽  
pp. 21292-21305 ◽  
Author(s):  
Satrajit Indu ◽  
Krishna P. Kaliappan
Keyword(s):  
One Pot ◽  
Fundamental Parameters ◽  
Simple Tool ◽  
Multistep Reactions ◽  
Synthetic Efficiency

We propose a generalized and informative [a,b,c,d] nomenclature for various types of one-pot multistep reactions, which emphasizes the fundamental parameters that define the synthetic efficiency of such transformations.

scholarly journals A Spatially Orthogonal Hierarchically Porous Acid-Base Catalyst for Cascade and Antagonistic Reactions

2020 ◽  
Author(s):  
Mark Isaacs ◽  
christopher parlett ◽  
neil robinson ◽  
Lee Durndell ◽  
Jinesh Manayil ◽  
...  
Keyword(s):  
Building Blocks ◽  
Solid Base ◽  
Industrial Chemistry ◽  
One Pot ◽  
Hierarchically Porous ◽  
Chemical Manufacturing ◽  
Multistep Reactions ◽  
Substrate Channelling ◽  
Complex Organic ◽  
Acid Coating

<p>Complex organic molecules are of great importance to academic and industrial chemistry and typically synthesised from smaller building blocks by multistep reactions. The ability to perform multiple (distinct) transformations in a single reactor would greatly reduce the number of manipulations required for chemical manufacturing, and hence the development of multifunctional catalysts for such one-pot reactions is highly desirable. Here we report the synthesis of a hierarchically porous framework, in which the macropores are selectively functionalised with a sulfated zirconia solid acid coating, while the mesopores are selectively functionalised with MgO solid base nanoparticles. Active site compartmentalisation and substrate channelling protects base catalysed triacylglyceride transesterification from poisoning by free fatty acid impurities (even at 50 mol%), and promotes the efficient two-step cascade deacetylation-Knoevenagel condensation of dimethyl acetals to cyanoates.<br></p>

ChemInform Abstract: L-Rhamnulose-1-phosphate Aldolase fromThermotoga maritima in Organic Synthesis: One-Pot Multistep Reactions for the Preparation of Imino- and Nitrocyclitols.

ChemInform ◽  
2015 ◽  
Vol 46 (39) ◽  
pp. no-no
Author(s):  
Isabel Oroz-Guinea ◽  
Karel Hernandez ◽  
Flora Camps Bres ◽  
Christine Guerard-Helaine ◽  
Marielle Lemaire ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
One Pot ◽  
Multistep Reactions

scholarly journals L -Rhamnulose-1-phosphate Aldolase from Thermotoga maritima in Organic Synthesis: One-Pot Multistep Reactions for the Preparation of Imino- and Nitrocyclitols

2015 ◽  
Vol 357 (8) ◽  
pp. 1951-1960 ◽  
Author(s):  
Isabel Oroz-Guinea ◽  
Karel Hernández ◽  
Flora Camps Bres ◽  
Christine Guérard-Hélaine ◽  
Marielle Lemaire ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Thermotoga Maritima ◽  
One Pot ◽  
Multistep Reactions

scholarly journals A Spatially Orthogonal Hierarchically Porous Acid-Base Catalyst for Cascade and Antagonistic Reactions

2020 ◽  
Author(s):  
Mark Isaacs ◽  
christopher parlett ◽  
neil robinson ◽  
Lee Durndell ◽  
Jinesh Manayil ◽  
...  
Keyword(s):  
Building Blocks ◽  
Solid Base ◽  
Industrial Chemistry ◽  
One Pot ◽  
Hierarchically Porous ◽  
Chemical Manufacturing ◽  
Multistep Reactions ◽  
Substrate Channelling ◽  
Complex Organic ◽  
Acid Coating

<p>Complex organic molecules are of great importance to academic and industrial chemistry and typically synthesised from smaller building blocks by multistep reactions. The ability to perform multiple (distinct) transformations in a single reactor would greatly reduce the number of manipulations required for chemical manufacturing, and hence the development of multifunctional catalysts for such one-pot reactions is highly desirable. Here we report the synthesis of a hierarchically porous framework, in which the macropores are selectively functionalised with a sulfated zirconia solid acid coating, while the mesopores are selectively functionalised with MgO solid base nanoparticles. Active site compartmentalisation and substrate channelling protects base catalysed triacylglyceride transesterification from poisoning by free fatty acid impurities (even at 50 mol%), and promotes the efficient two-step cascade deacetylation-Knoevenagel condensation of dimethyl acetals to cyanoates.<br></p>

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