Tuning the properties of a cyclic RGD-containing tetrapeptide through backbone fluorination

2019 ◽  
Vol 17 (3) ◽  
pp. 664-674 ◽  
Author(s):  
Catherine Au ◽  
Christina Gonzalez ◽  
Yun Cheuk Leung ◽  
Flora Mansour ◽  
Johny Trinh ◽  
...  
Keyword(s):  
Biological Activity ◽  
Molecular Conformation ◽  
Synthetic Efficiency

Fluorination alters a cyclic peptide's synthetic efficiency, its molecular conformation, and its biological activity.

ChemInform Abstract: Synthesis, Molecular Conformation and Biological Activity of 6-Amino-5-azacytidine.

ChemInform ◽  
1990 ◽  
Vol 21 (4) ◽  
Author(s):  
A. PISKALA ◽  
N. B. HANNA ◽  
J. ZAJICEK ◽  
A. CIHAK
Keyword(s):  
Biological Activity ◽  
Molecular Conformation

A new structure of a serotonin salt: comparison and conformational analysis of all known serotonin complexes

2013 ◽  
Vol 69 (9) ◽  
pp. 1055-1061 ◽  
Author(s):  
Denis Rychkov ◽  
Elena V. Boldyreva ◽  
Nikolay A. Tumanov
Keyword(s):  
Hydrogen Bonding ◽  
Biological Activity ◽  
Conformational Analysis ◽  
Molecular Conformation ◽  
Biological Properties ◽  
Stacking Interactions ◽  
Salt Formation ◽  
Counter Ion ◽  
Unknown Structure ◽  
Conformation Stability

Four serotonin salt structures (serotonin adipate, C10H13N2O+·C6H9O4−, is a previously unknown structure) were analysed to understand the influence of the anion on serotonin conformation. Hydrogen bonding alone favours a flat conformation, whereas additional stacking interactions between ions may possibly account for the nonplanar conformation. Since molecular conformation, stability and biological activity are interrelated, one can consider influencing the chemical and biological properties of serotonin by selecting an appropriate counter-ion for salt formation.

scholarly journals The Eigenproblem Translated for Alignment of Molecules

Symmetry ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1027 ◽  
Author(s):  
Lorentz Jäntschi
Keyword(s):  
Amino Acids ◽  
Biological Activity ◽  
Molecular Conformation ◽  
Living Cells ◽  
Molecular Alignment ◽  
Cartesian Coordinates ◽  
Naturally Occurring ◽  
Cartesian System ◽  
Glycolysis Pathway ◽  
Living Organisms

Molecular conformation as a subproblem of the geometrical shaping of the molecules is essential for the expression of biological activity. It is well known that from the series of all possible sugars, those that are most naturally occurring and usable by living organisms as a source of energy—because they can be phosphorylated by hexokinase, the first enzyme in the glycolysis pathway—are D-sugars (from the Latin dextro). Furthermore, the most naturally occurring amino acids in living cells are L-sugars (from the Latin laevo). However, a problem arises in dealing with the comparison of their conformers. One alternative way to compare sugars is via their molecular alignment. Here, a solution to the eigenproblem of molecular alignment is communicated. The Cartesian system is rotated, and eventually translated and reflected until the molecule arrives in a position characterized by the highest absolute values of the eigenvalues observed on the Cartesian coordinates. The rotation alone can provide eight alternate positions relative to the reflexes of each coordinate.

1H NMR conformational study of fusicoccin and related compounds: molecular conformation and biological activity

1991 ◽  
Vol 30 (1) ◽  
pp. 137-146 ◽  
Author(s):  
A. Ballio ◽  
S. Castellano ◽  
S. Cerrini ◽  
A. Evidente ◽  
G. Randazzo ◽  
...  
Keyword(s):  
Biological Activity ◽  
1H Nmr ◽  
Molecular Conformation ◽  
Conformational Study ◽  
Related Compounds

Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

1973 ◽  
Vol 31 ◽  
pp. 378-379
Author(s):  
G. Kasnic ◽  
S. E. Stewart ◽  
C. Urbanski
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Human Breast Cancer ◽  
Osteogenic Sarcoma ◽  
Human Tumor ◽  
Structural Similarity ◽  
Cell Tumor ◽  
Human Breast ◽  
Human Tumor Cell ◽  
Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

Sign in / Sign up

Export Citation Format

Share Document