Pyridine hydrochloride-catalyzed thiolation of alkenes: divergent synthesis of allyl and vinyl sulfides

Divergent synthesis of allyl and vinyl sulfides by a Py-HCl catalyzed tandem thiolation–elimination reaction between N-thiosuccinimides and alkenes.

Rational design of a fluorescent poly(N-aryleneindole ether sulfone) switch by cation–π interactions

A fluorescence emission on–off switch is achieved by adjusting the assembly of poly(N-aryleneindole ether sulfone) (PESIN) and pyridine hydrochloride via the cation–π interactions.

Synthesis and Characterization of S-Tenatoprazole

Make 5-methoxy-2-mercapto-imidazo[4,5-b]pyridine and 2-chloro-3,5-dimethyl-4-methoxy-pyridine hydrochloride as the starting materials, in alkaline conditions, use nucleophilic substitution to generate the prochiral sulfide: 2-[2-(4-methoxy-3 ,5-dimethyl-pyridine) methylmercapto]-5-methoxy-imidazo [4,5-b] pyridine. After recrystallization twice, gain the product with the yield of 80%, and the purity of 99.6% and above. Then make D-(-)-diethyl tartrate and tetraisopropyl titanate as the chiral reagents, in alkaline conditions, use cumene hydroperoxide oxide to oxidize prochiral sulfide, for synthesis of (S)-Tenatoprazole, and the results showed that when, the reaction temperature was , and reaction time was 20h, the result was the best.