Rational design of a fluorescent poly(N-aryleneindole ether sulfone) switch by cation–π interactions

2015 ◽  
Vol 6 (5) ◽  
pp. 697-702 ◽  
Author(s):  
Guanjun Chang ◽  
Li Yang ◽  
Shenye Liu ◽  
Runxiong Lin ◽  
Jingsong You
Keyword(s):  
Rational Design ◽  
Fluorescence Emission ◽  
Pyridine Hydrochloride ◽  
Π Interactions

A fluorescence emission on–off switch is achieved by adjusting the assembly of poly(N-aryleneindole ether sulfone) (PESIN) and pyridine hydrochloride via the cation–π interactions.

Rational design of a novel indole-based microporous organic polymer: enhanced carbon dioxide uptake via local dipole–π interactions

2016 ◽  
Vol 4 (7) ◽  
pp. 2517-2523 ◽  
Author(s):  
Guanjun Chang ◽  
Zhenfang Shang ◽  
Tao Yu ◽  
Li Yang
Keyword(s):  
Carbon Dioxide ◽  
Rational Design ◽  
Organic Polymer ◽  
Π Interactions ◽  
Carbon Dioxide Uptake

An indole-based microporous organic polymer (PINK) is achieved and it exhibits good performance for carbon dioxide uptake via the local dipole–π interactions.

scholarly journals A fluorescent calix[4]arene with naphthalene units at the upper rim exhibits long fluorescence emission lifetime without fluorescence quenching

RSC Advances ◽  
2021 ◽  
Vol 11 (19) ◽  
pp. 11651-11654
Author(s):  
Masaki Takahashi ◽  
Naoya Tsuji ◽  
Kohei Yazaki ◽  
Yoshihisa Sei ◽  
Makoto Obata
Keyword(s):  
Fluorescence Quenching ◽  
Dft Calculations ◽  
Fluorescence Lifetime ◽  
Fluorescence Emission ◽  
Π Interactions ◽  
Emission Lifetime ◽  
Td Dft ◽  
Upper Rim ◽  
Macrocyclic Structure

Macrocyclic structure brings long fluorescence lifetime emission without fluorescence quenching and TD-DFT calculations revealed π–π interactions between the naphthalene rings.

scholarly journals Dendron-Polymer Hybrids as Tailorable Coronae of Single-Walled Carbon Nanotube

2021 ◽  
Author(s):  
Verena Wulf ◽  
Gadi Slor ◽  
Parul Rathee ◽  
Roey J. Amir ◽  
Gili Bisker
Keyword(s):  
Rational Design ◽  
Near Infrared ◽  
Fluorescence Emission ◽  
Building Blocks ◽  
Single Walled Carbon Nanotube ◽  
Single Walled Carbon ◽  
Amphiphilic Macromolecules ◽  
End Groups ◽  
High Degree ◽  
Walled Carbon Nanotubes

Single-walled carbon nanotubes (SWCNTs), non-covalently functionalized by synthetic polymers, find widespread applications including sensing and imaging. Identifying new amphiphiles with interchangeable building blocks that can form unique coronae around the SWCNT, customized for a specific application, is thus of great interest. We present polymer-dendron hybrids, composed of hydrophobic dendrons and hydrophilic polyethylene glycol (PEG), as amphiphilic macromolecules with high degree of structural freedom, for suspending SWCNTs in aqeous solution. Based on a set of four PEG-dendrons differing in their dendritic end-groups, we show thst differences in the chemical structure of the hydrophobic end-groups control the interactions of the PEG-dendrons with the SWCNT-surface. These interactions led to differences in the intrinsic near-infrared fluorescence emission of the SWCNTs and affected the PEG-dendron susceptibility to enzymatic degradation, which was monitored by the SWCNT fluorescent signal. Our findings open new avenues for rational design of SWCNT functionalization, and optical sensing of enzymatic activity<br>

scholarly journals Dendron-Polymer Hybrids as Tailorable Coronae of Single-Walled Carbon Nanotube

2021 ◽  
Author(s):  
Verena Wulf ◽  
Gadi Slor ◽  
Parul Rathee ◽  
Roey J. Amir ◽  
Gili Bisker
Keyword(s):  
Rational Design ◽  
Near Infrared ◽  
Fluorescence Emission ◽  
Building Blocks ◽  
Single Walled Carbon Nanotube ◽  
Single Walled Carbon ◽  
Amphiphilic Macromolecules ◽  
End Groups ◽  
High Degree ◽  
Walled Carbon Nanotubes

Single-walled carbon nanotubes (SWCNTs), non-covalently functionalized by synthetic polymers, find widespread applications including sensing and imaging. Identifying new amphiphiles with interchangeable building blocks that can form unique coronae around the SWCNT, customized for a specific application, is thus of great interest. We present polymer-dendron hybrids, composed of hydrophobic dendrons and hydrophilic polyethylene glycol (PEG), as amphiphilic macromolecules with high degree of structural freedom, for suspending SWCNTs in aqeous solution. Based on a set of four PEG-dendrons differing in their dendritic end-groups, we show thst differences in the chemical structure of the hydrophobic end-groups control the interactions of the PEG-dendrons with the SWCNT-surface. These interactions led to differences in the intrinsic near-infrared fluorescence emission of the SWCNTs and affected the PEG-dendron susceptibility to enzymatic degradation, which was monitored by the SWCNT fluorescent signal. Our findings open new avenues for rational design of SWCNT functionalization, and optical sensing of enzymatic activity<br>

scholarly journals A novel class of polymeric fluorescent dyes assembled using a DNA synthesizer

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243218
Author(s):  
Tracy Matray ◽  
Sharat Singh ◽  
Hesham Sherif ◽  
Kenneth Farber ◽  
Erin Kwang ◽  
...  
Keyword(s):  
Rational Design ◽  
Tertiary Structure ◽  
Fluorescent Dyes ◽  
Polymer System ◽  
Fluorescence Emission ◽  
Proper Function ◽  
Molecular Architecture ◽  
Primary Sequence ◽  
Phosphoramidite Chemistry ◽  
And Control

In the pursuit of a novel class of fluorescent dyes we have developed a programmable polymer system that enables the rational design and control of macromolecular constructs through simple control of polymer primary sequence. These polymers are assembled using standard phosphoramidite chemistry on a DNA synthesizer which allows for extremely rapid prototyping and enables many permutations due to the large selection of phosphoramidite monomers presently available on the market. This programmability to some extent allows us to control the interactions/spacing of payload molecules distributed along the designed polymeric backbone. Control of molecular architecture using this technology has allowed us to address the long-standing technical issue of contact quenching between fluorescent dyes offering new possibilities in the life sciences arena. Much like peptidic sequences coding for enzymes, cofactors, and receptors (all needing control of tertiary structure for proper function via primary sequence) our programmable system approaches a similar endpoint using a phosphate based polymeric backbone assembled in a completely automated fashion. Using this novel technology, we have efficiently synthesized several types of fluorescent dyes and demonstrated the programmability in molecule design, including the increases in brightness of the fluorescence emission.

Molecular insights on the dynamic stability of peptide nucleic acid functionalized carbon and boron nitride nanotubes

2021 ◽  
Vol 23 (1) ◽  
pp. 219-228
Author(s):  
Nabanita Saikia ◽  
Mohamed Taha ◽  
Ravindra Pandey
Keyword(s):  
Nucleic Acid ◽  
Boron Nitride ◽  
Nucleic Acids ◽  
Dynamic Stability ◽  
Peptide Nucleic Acid ◽  
Rational Design ◽  
Peptide Nucleic Acids ◽  
Boron Nitride Nanotubes ◽  
Molecular Hybrids ◽  
Single Wall Nanotubes

The rational design of self-assembled nanobio-molecular hybrids of peptide nucleic acids with single-wall nanotubes rely on understanding how biomolecules recognize and mediate intermolecular interactions with the nanomaterial's surface.

Optimizing electron density of nickel sulfide electrocatalysts through sulfur vacancy engineering for alkaline hydrogen evolution

2020 ◽  
Vol 8 (35) ◽  
pp. 18207-18214
Author(s):  
Dongbo Jia ◽  
Lili Han ◽  
Ying Li ◽  
Wenjun He ◽  
Caichi Liu ◽  
...  
Keyword(s):  
Hydrogen Evolution ◽  
Electron Density ◽  
Rational Design ◽  
Nickel Sulfide ◽  
Catalytic Performance ◽  
Sulfide Catalysts ◽  
Sulfur Vacancy

A novel, rational design for porous S-vacancy nickel sulfide catalysts with remarkable catalytic performance for alkaline HER.

Rational design of annotine analogues with increased inhibitory activity towards acetylcholinesterase

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
ES Halldorsdottir ◽  
S Oddsson ◽  
AM Einarsdottir ◽  
B Eiriksdottir ◽  
NM Kowal ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Rational Design

Anticoagulant Activity of Hirulog™, a Direct Thrombin Inhibitor, in Humans

1993 ◽  
Vol 69 (02) ◽  
pp. 157-163 ◽  
Author(s):  
Irving Fox ◽  
Adrian Dawson ◽  
Peter Loynds ◽  
Jane Eisner ◽  
Kathleen Findlen ◽  
...  
Keyword(s):  
Rational Design ◽  
Therapeutic Potential ◽  
Anticoagulant Activity ◽  
Subcutaneous Administration ◽  
Direct Thrombin Inhibitor ◽  
Controlled Study ◽  
Thrombin Inhibitor ◽  
Thrombin Time ◽  
Thrombotic Disease ◽  
Dose Dependent

SummaryHirulog™ (BG8967) is a direct thrombin inhibitor built by rational design using the protein hirudin as a model (Maraganore et al. [1990]; Biochemistry 29: 7095–101). In order to evaluate the therapeutic potential for hirulog in the management of thrombotic disease, the tolerability and anticoagulant activity of the agent were examined in a study of human volunteers.In a randomized, placebo-controlled study (n = 54), the intravenous infusion of hirulog over 15 min showed a rapid, dose-dependent prolongation of activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT). There was a corresponding dose-dependent increase in plasma hirulog levels. The peptide was rapidly cleared with a half-life of 36 min and a total body clearance rate for the peptide of 0.43 1 kg−1 h−1. Similar activity was observed following subcutaneous injection but with sustained pharmacodynamic and pharmacokinetic behavior. There was a significant correlation between pharmacokinetic and pharmacodynamic variables for both intravenous (r = 0.8, p <0.001) and subcutaneous administration (r = 0.7, p = 0.002).To evaluate the possible interactions of aspirin on the tolerability and anticoagulant activity of intravenous hirulog, a cross-over design was employed in eight subjects. Aspirin administration did not modify the peptide’s activity. At the administered dose of 0.6 mg kg−1 h−1 for 2 h, hirulog infusion prolonged APTT from 230 to 260% baseline. The infusion of hirulog in subjects who had received aspirin was not associated with any significant changes in the template bleeding time.The final phase of the study examined the activity and tolerability of hirulog in ten subjects during prolonged intravenous infusions for up to 24 h. The peptide (0.3 mg kg−1 h−1) exhibited sustained anticoagulant activity with no evidence for a cumulative effect. During hirulog infusion, APTT was prolonged from 210 to 250% baseline.In all phases of the study, hirulog administration was generally well-tolerated.Our observations show that hirulog is an active antithrombin agent with excellent tolerability in humans. As a direct thrombin inhibitor, hirulog provides a novel approach for the management of thrombotic disease.

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