Pyridine hydrochloride-catalyzed thiolation of alkenes: divergent synthesis of allyl and vinyl sulfides

2020 ◽  
Vol 7 (21) ◽  
pp. 3474-3479
Author(s):  
Shiwen Liu ◽  
Lili Wang ◽  
Zhipeng Ma ◽  
Xiaojun Zeng ◽  
Bo Xu
Keyword(s):  
Elimination Reaction ◽  
Pyridine Hydrochloride ◽  
Vinyl Sulfides

Divergent synthesis of allyl and vinyl sulfides by a Py-HCl catalyzed tandem thiolation–elimination reaction between N-thiosuccinimides and alkenes.

Potential antidepressants: Synthesis of two 4-(aminoalkoxy)dibenzo[b,e]thiepin-11(6H)-ones

1989 ◽  
Vol 54 (1) ◽  
pp. 225-228 ◽  
Author(s):  
Irena Červená ◽  
Jiří Holubek ◽  
Emil Svátek ◽  
Jan Metyš ◽  
Martin Valchář ◽  
...  
Keyword(s):  
Sodium Salt ◽  
Anticonvulsant Effect ◽  
Rat Hypothalamus ◽  
Pyridine Hydrochloride ◽  
Antihypoxic Effect

Heating of 4-methoxydibenzo[b,e]thiepin-11(6H)-one with pyridine hydrochloride to 225 to 235 °C effected demethylation and gave IV. Its sodium salt reacted with 3-dimethylaminopropyl chloride in ethanol and afforded the 4-(3-dimethylaminopropoxy) compound II. The isomeric ether III was prepared via the 4-(4-bromobutoxy) compound V. Hydrochloride of II (VÚFB-17 033) inhibited mildly the binding of [3H]desipramine in rat hypothalamus, had antireserpine activity in rats, mild anticonvulsant effect, and antihypoxic effect in the test of nitrogen anoxia in mice.

scholarly journals Studies on the Elimination Reaction of d-Amino Acid Oxidase with α-Amino-β-chlorobutyrate

1973 ◽  
Vol 248 (6) ◽  
pp. 1946-1955 ◽  
Author(s):  
Christopher T. Walsh ◽  
Elizabeth Krodel ◽  
Vincent Massey ◽  
Robert H. Abeles
Keyword(s):  
Amino Acid ◽  
Acid Oxidase ◽  
Elimination Reaction ◽  
Amino Acid Oxidase

scholarly journals Computational Design of Radical Recognition Assay with the Possible Application of Cyclopropyl Vinyl Sulfides as Tunable Sensors

2021 ◽  
Vol 22 (14) ◽  
pp. 7637
Author(s):  
Liliya T. Sahharova ◽  
Evgeniy G. Gordeev ◽  
Dmitry B. Eremin ◽  
Valentine P. Ananikov
Keyword(s):  
Uv Light ◽  
Computational Design ◽  
Energy Profiles ◽  
Vinyl Sulfides ◽  
Tunable Sensors ◽  
Radical Generation ◽  
Metal Catalyzed ◽  
Dynamics Simulations ◽  
Simulations And Modeling ◽  
Insight Into

The processes involving the capture of free radicals were explored by performing DFT molecular dynamics simulations and modeling of reaction energy profiles. We describe the idea of a radical recognition assay, where not only the presence of a radical but also the nature/reactivity of a radical may be assessed. The idea is to utilize a set of radical-sensitive molecules as tunable sensors, followed by insight into the studied radical species based on the observed reactivity/selectivity. We utilize this approach for selective recognition of common radicals—alkyl, phenyl, and iodine. By matching quantum chemical calculations with experimental data, we show that components of a system react differently with the studied radicals. Possible radical generation processes were studied involving model reactions under UV light and metal-catalyzed conditions.

Phosphonium salts. III. The action of cyanide ion and other nucleophiles on some bis-phosphonium salts

1969 ◽  
Vol 22 (7) ◽  
pp. 1405 ◽  
Author(s):  
JJ Brophy ◽  
MJ Gallagher
Keyword(s):  
Sodium Azide ◽  
Sodium Methoxide ◽  
Sodium Acetate ◽  
Potassium Cyanide ◽  
Dimethyl Sulphoxide ◽  
High Yield ◽  
Phosphonium Salts ◽  
Elimination Reaction ◽  
Cyanide Ion ◽  
Reaction Proceeds

Cyclic and acyclic bis-phosphonium salts with a two-carbon bridge are smoothly cleaved to phosphines in high yield by potassium cyanide in dimethyl sulphoxide. Evidence is presented that the reaction proceeds by an elimination-addition sequence. An elimination reaction also occurs when sodium methoxide, sodium azide, sodium acetate, and triethylamine react with ethane-1,2-bis(tri-phenylphosphonium) dibromide. ��� In a novel reaction, triphenylphosphine is converted into its oxide by a mixture of sodium azide and dimethyl sulphoxide.

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