Bilaterally displaced Schwalbe’s line: An unusual presentation of Axenfeld Rieger syndrome

To report a case on unusual presentation of Axenfeld Reiger (A-R) syndrome. Axenfeld Rieger syndrome commonly presents with prominent Schwalbe’s line near the limbus. Presentation with displaced Schwalbe’s line is rarely reported. We report 2 cases who presented with bilaterally displaced Schwalbe ring as strange cord like structure in anterior chamber with iris tissue adhesions. Axenfeld – Reiger syndrome is an autosomal dominant disease with ocular findings involving cornea (megalocornea), iris (iris atrophy,correctopia) and angle (anterior insertion of iris, prominent Schwalbe line). We report unsual case of detached Schwalbe’s line with iris tissue adhesions in anterior chamber A-R syndrome.

Engineering multifunctional bactericidal nanofibers for abdominal hernia repair

The engineering of multifunctional surgical bactericidal nanofibers with inherent suitable mechanical and biological properties, through facile and cheap fabrication technology, is a great challenge. Moreover, hernia, which is when organ is pushed through an opening in the muscle or adjacent tissue due to damage of tissue structure or function, is a dire clinical challenge that currently needs surgery for recovery. Nevertheless, post-surgical hernia complications, like infection, fibrosis, tissue adhesions, scaffold rejection, inflammation, and recurrence still remain important clinical problems. Herein, through an integrated electrospinning, plasma treatment and direct surface modification strategy, multifunctional bactericidal nanofibers were engineered showing optimal properties for hernia repair. The nanofibers displayed good bactericidal activity, low inflammatory response, good biodegradation, as well as optimal collagen-, stress fiber- and blood vessel formation and associated tissue ingrowth in vivo. The disclosed engineering strategy serves as a prominent platform for the design of other multifunctional materials for various biomedical challenges.

A Review: Progress in Preventing Tissue Adhesions from a Biomaterials Perspective

Postoperative adhesions (POA) are one of the main problems of the patients and their common complaints. It is considered to be closely associated with the healing mechanism of the damaged...

Mathematical models for cell migration: a non-local perspective

We provide a review of recent advancements in non-local continuous models for migration, mainly from the perspective of its involvement in embryonal development and cancer invasion. Particular emphasis is placed on spatial non-locality occurring in advection terms, used to characterize a cell’s motility bias according to its interactions with other cellular and acellular components in its vicinity (e.g. cell–cell and cell–tissue adhesions, non-local chemotaxis), but we also briefly address spatially non-local source terms. Following a short introduction and description of applications, we give a systematic classification of available PDE models with respect to the type of featured non-localities and review some of the mathematical challenges arising from such models, with a focus on analytical aspects. This article is part of the theme issue ‘Multi-scale analysis and modelling of collective migration in biological systems’.

Histological Studies of Putrid Abdominal Adhesions as Tool in the Forensic Medical Examination

Histological examination of putrid adhesions is informative to determine the time of death and the etiology of origin of adhesions. Differential staining of adhesions with hematoxylin and eosin, trichrome by Masson, Zerbino with prescription death up to 7 days allows to define the appearance of the cellular composition, staining of muscle fibers on Zerbino and collagen and reticular fibers. In case of death from 7 to 10 days, the loss of the cellular composition in the color with hematoxylin and eosin is determined in tissue adhesions. This preserves the color of the muscle cells on Zerbino and staining of collagen and reticular fibers in the color of trigram by Masson. In the period from 10 to 14 days after the death, adhesions additionally lose the ability to staining of muscle cells on Zerbino. In case of death of more than 14 days, reticular fibers don’t turn spinach. Color is kept only for the collagen fibers in the color of trigram by Masson. In the case of traumatic and non-traumatic origin of putrid modified adhesions on histological sections of adhesions in color according to Perls, the signs of hemorrhage in the area of adhesions in the presence of compounds of trivalent iron are identified. In case of accumulation of the dye in the blue-green color in the form of granules in the soldering and soft tissues of the insertion or impregnation of the dye of the connective tissue and putrid modified muscle fibers, it is possible to diagnose traumatic origin of putrid modified adhesions, and in the absence of positive reactions – their non-traumatic origin.

Right heart failure in dairy cow caused by traumatic pericaridtis: Case report

In this paper there is presented right heart failure in 10 years' old cow. During last year it had changeable apetite, profuse diarrhea as well as fluctuations in milk production. In the mentoned period it did not conceive. By examination of peripheral blood vessels, there were determined some changes in pulse quality (p.rarus et parvus) and charge of neck veins (venous stasis). Under the skin in sternum region there was noticeable swelling of pastose condensation. Visible mucosas were pail. Heart sounds were barely audible, and at puncta optima aorte and a.pulmonalis could not be heard at all. On the right side of the chest, first and second heart tones audability was better, compared to those of the opposite side. By examining of the reticulum by testing on foreign body presence, the animal did not react painfully. On the basis of these data, there was diagnosed: Insufficientio cordis et pericarditis traumatica in obs. By laboratory analysis of blood samples, trere was determined hypochromic and microcytic anemia, mild leukocytosis with neutrophilia, as well as hyperproteinemia characterized by hypoalbuminemia and hyperglobulinemia. These findings pointed out to iron deficiency, inflammatory process and reduced syntetic ability of liver. For economic reasons, the animal was sent to the slaughter. By pathomorphological examination there were determined connective tissue adhesions among reticulum, diaphragm, pericardium and the base of the heart. The foreign body was located in the base of the heart where a large abscess was formed. Pericardium was thickened, and on its inner side there were grained sediments of fibrin and purulent content. Right ventricle of the heart was expanded and the wall was thinned. By histopathological examination of the heart, there was found out thickened pericardium with fibrin sediments, and the wall of the abscess located on the base of the heart was formed of connective tissue largely infiltrated by neutrophyl granulocytes. On the basis of the findings, there was diagnosed Pericarditis purulenta chronica.