A Review: Progress in Preventing Tissue Adhesions from a Biomaterials Perspective

2021 ◽  
Author(s):  
Bahareh Kheilnezhad ◽  
Afra Hadjizadeh
Keyword(s):  
Postoperative Adhesions ◽  
Tissue Adhesions

Postoperative adhesions (POA) are one of the main problems of the patients and their common complaints. It is considered to be closely associated with the healing mechanism of the damaged...

scholarly journals Engineering multifunctional bactericidal nanofibers for abdominal hernia repair

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Samson Afewerki ◽  
Nicole Bassous ◽  
Samarah Vargas Harb ◽  
Marcus Alexandre F. Corat ◽  
Sushila Maharjan ◽  
...  
Keyword(s):  
Hernia Repair ◽  
Biological Properties ◽  
Abdominal Hernia ◽  
Fabrication Technology ◽  
Tissue Adhesions ◽  
Blood Vessel Formation ◽  
Clinical Challenge ◽  
Engineering Strategy ◽  
Clinical Problems

AbstractThe engineering of multifunctional surgical bactericidal nanofibers with inherent suitable mechanical and biological properties, through facile and cheap fabrication technology, is a great challenge. Moreover, hernia, which is when organ is pushed through an opening in the muscle or adjacent tissue due to damage of tissue structure or function, is a dire clinical challenge that currently needs surgery for recovery. Nevertheless, post-surgical hernia complications, like infection, fibrosis, tissue adhesions, scaffold rejection, inflammation, and recurrence still remain important clinical problems. Herein, through an integrated electrospinning, plasma treatment and direct surface modification strategy, multifunctional bactericidal nanofibers were engineered showing optimal properties for hernia repair. The nanofibers displayed good bactericidal activity, low inflammatory response, good biodegradation, as well as optimal collagen-, stress fiber- and blood vessel formation and associated tissue ingrowth in vivo. The disclosed engineering strategy serves as a prominent platform for the design of other multifunctional materials for various biomedical challenges.

A Novel Bioresorbable Film Reduces Postoperative Adhesions After Infant Cardiac Surgery

2008 ◽  
Vol 86 (2) ◽  
pp. 614-621 ◽  
Author(s):  
Andrew J. Lodge ◽  
Winfield J. Wells ◽  
Carl L. Backer ◽  
James E. O'Brien ◽  
Erle H. Austin ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Postoperative Adhesions

Application of a Viscous Liquid as an Aerosol for Post-Operative Adhesion Prevention: First Engineering Steps Towards Nozzle Design

2020 ◽  
Author(s):  
P. Alex Smith ◽  
Timothy J. Keane ◽  
Stefano Serpelloni ◽  
Stephen G. Ramon ◽  
Francesca Taraballi
Keyword(s):  
Thin Film ◽  
Minimally Invasive ◽  
Viscous Liquid ◽  
Scar Tissue ◽  
Adhesion Prevention ◽  
Nozzle Design ◽  
Postoperative Adhesions ◽  
Internal Organs ◽  
Spray Pattern ◽  
3D Printed

Abstract Postoperative adhesions are scar tissue that form between internal organs after surgery, leading to devastating life-long complications. Current adhesion barriers used clinically are solid sheets which can only be applied in open surgeries through large incisions. We have developed a material which can be applied as a liquid in minimally invasive surgeries which transitions into a solid thin film barrier upon contact with warm tissue. However, to be effective, it must be sprayed, and spraying a viscous liquid consistently is challenging. We proposed using a gas dispersant to facilitate aerosolization. In this study, we compared a commercially available nozzle without gas dispersant to a custom 3D printed nozzle with gas dispersant. For comparison, we measured both spray pattern and stiffness of the resulting gel. We found that when sprayed with gas dispersant, the spray pattern covered a larger area, and the resulting gel was stiffer than when sprayed without gas dispersant.

Postoperative Adhesions After Application of Topical Hemostatic Agents: Outcomes in a Rat Partial Nephrectomy Model

Urology ◽  
2011 ◽  
Vol 78 (4) ◽  
pp. 970.e9-970.e14 ◽  
Author(s):  
Hüsnü Tokgöz ◽  
Sibel Bektaş ◽  
Volkan Hancı ◽  
Bülent Erol ◽  
Bülent Akduman ◽  
...  
Keyword(s):  
Partial Nephrectomy ◽  
Postoperative Adhesions ◽  
Hemostatic Agents

scholarly journals Retrospective analysis of patients ineffectively operated on for the polycystic ovaries syndrome

1997 ◽  
Vol 43 (2) ◽  
pp. 29-31
Author(s):  
A. G. Khomasuridze ◽  
E. G. Feinberg ◽  
R. A. Manusharova ◽  
N. I. Bablidze
Keyword(s):  
Retrospective Analysis ◽  
Treatment Strategy ◽  
Surgical Intervention ◽  
Ovarian Cysts ◽  
Postoperative Adhesions ◽  
Polycystic Ovaries ◽  
Pelvic Organs ◽  
Hypothalamic Syndrome

A retrospective analysis of the efficacy of surgical intervention (demedullation of both ovaries) for the polycystic ovaries syndrome (POS) in 245 women aged 28 to 40 was carried out. Primary POS was diagnosed in 138 women (the ovarian form) and the endocrine metabolic form of the hypothalamic syndrome with secondary POS in 107. The findings showed anovulation to be responsible for infertility in 34.5% of cases, postoperative adhesions in the pelvic organs and obstruction of the uterine tubes in 34.2%, hyperprolactinemia in 11%, endometriosis in 18.3%, and ovarian cysts in 1% of cases. Treatment strategy in patients ineffectively operated on for POS cannot be standard and depends on the diseases which is diagnosed after surgery.  

scholarly journals Postoperative adhesions in gynecologic surgery: a committee opinion

2019 ◽  
Vol 112 (3) ◽  
pp. 458-463
Author(s):  
Alan Penzias ◽  
Kristin Bendikson ◽  
Tommaso Falcone ◽  
Susan Gitlin ◽  
Clarisa Gracia ◽  
...  
Keyword(s):  
Gynecologic Surgery ◽  
Postoperative Adhesions

scholarly journals Ovariopexy—Before and after Endometriosis Surgery

Biomedicines ◽  
2020 ◽  
Vol 8 (12) ◽  
pp. 533
Author(s):  
Juhi Dhanawat ◽  
Julian Pape ◽  
Damaris Freytag ◽  
Nicolai Maass ◽  
Ibrahim Alkatout
Keyword(s):  
Cost Effective ◽  
Postoperative Adhesions ◽  
Limited Evidence ◽  
Surgical Access ◽  
Pelvic Wall ◽  
Before And After ◽  
Lateral Pelvic Wall ◽  
Endometriosis Surgery ◽  
Excellent Tool ◽  
Very High

Endometriosis surgery is often very challenging. Key to complete resection of endometriosis is access to the retroperitoneum. Endometriosis can involve the ureter and uterine vessels, and ovary on the lateral pelvic wall makes retroperitoneal access difficult. Primary and post-surgical adhesions prevalence in endometriosis is very high. Ovariopexy, transposition of ovaries temporarily, is done for better surgical access and to reduce postoperative adhesions. We concluded that although limited evidence, ovariopexy is an excellent tool to aid endometriosis surgery and prevent postoperative adhesions. It is cost effective, simple and complication rate almost nil. More robust trials are required to substantiate evidence for its impact on preventing postoperative adhesions and its effect on fertility. In this review, we describe our technique of ovariopexy supplemented with a video, with the aim to put light on this useful and important technique, which is beneficial both for surgeons and patients.

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