Hematological Changes Following Oral Administration of Aqueous Root Bark Extract of Salacia lehmbachii in Albino Rats

2016 ◽  
Vol 6 (1) ◽  
pp. 1-8
Author(s):  
G Essiet ◽  
A Essien ◽  
L Takem ◽  
G Akuodor ◽  
F Udoh
Keyword(s):  
Oral Administration ◽  
Bark Extract ◽  
Albino Rats ◽  
Root Bark ◽  
Hematological Changes

Effect of administration of methanol root bark extract of Cussonia arborea on serum lipid profile and oxidative biomarker parameters in alloxan-induced diabetic rats

2016 ◽  
Author(s):  
Patrick Emeka Aba ◽  
Isaac Uzoma Asuzu
Keyword(s):  
Oxidative Stress ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Methanol Extract ◽  
Diabetic Rats ◽  
Bark Extract ◽  
Albino Rats ◽  
Root Bark ◽  
Oxidative Stress Biomarkers ◽  
And Oxidative Stress

This study investigated the effects of methanol extract of Cussonia arborea on serum lipid and oxidative stress biomarkers of alloxan-induced diabetic rats. A total of 72 male albino rats assigned into 6 groups of 12 rats per group were used. Groups 1-5 were made diabetic while group 6 were normal. Groups 1-4 were treated with 62.5, 125, 250 mg/kg of the extract and 2 mg/kg glibenclamide respectively while groups 5 and 6 received 10 ml/kg distilled water each. Total cholesterol, triglyceride, high density lipoprotein (HDL), malondiadehyde, catalase, and superoxide dismutase (SOD) were assayed on days 28, 56 and 84 post treatment. The results indicated that the extract significantly (p<0.05) reduced the levels of total cholesterol, triglyceride, malondialdehyde but significantly (p<0.05) increased the activities of SOD, catalase and the levels of HDL when compared to negative control. It was therefore concluded that methanol extract of C. arborea mitigated dyslipidaemia and oxidative stress.

scholarly journals Evaluation of Changes in Biochemical and Haematological Parameters of Albino Rats Following Subacute Oral Administration of Cinnamomum cassia (Cinnamon) Extract

2021 ◽  
pp. 91-99
Author(s):  
C. N. Okwuosa ◽  
N. C. Azubuike ◽  
C. P. Okorie
Keyword(s):  
Weight Gain ◽  
Oral Administration ◽  
Serum Alkaline Phosphatase ◽  
Stem Bark ◽  
Medical Laboratory ◽  
Haematological Parameters ◽  
Bark Extract ◽  
Albino Rats ◽  
Cinnamomum Cassia ◽  
Animal House

Background: Cinnamomum cassia stem bark is used traditionally for the treatment of digestive disorders, diabetes and to alleviate symptoms of cold or flu. Aim: The present study evaluated biochemical and haematological changes in male albino rats after exposure to the stem bark ethanolic extract of Cinnamomum cassia (SBECC). Study Design: An experimental study which lasted for 19 days. Place and Duration of Study: Department of Medical Laboratory Sciences and Animal House, College of Medicine, University of Nigeria, Enugu Campus, between April 2019 and August 2019. Methodology: Twenty (20) rats weighing 130-170 g were used. Graded doses (100, 200 and 400mg/kg body weight) of the SBECC were orally administered to the animals in groups B, C and D respectively, once daily for 18 days. Group A served as the normal control and received only the vehicle (5ml/kg of 0.25N sodium carbonate). On Day 19, body weights of the rats were measured and blood samples obtained via retro-orbital puncture, were placed into plain tubes and tri-potassium ethylene diamine tetra-acetic acid (K3EDTA) containers for biochemical and haematological studies respectively. Results:  Weight gain was observed in all treatment groups and control. The highest and lowest percentage weight gain was observed in Group C (51%) and Group B (33%) respectively. All the doses of the extract significantly decreased serum cholesterol levels when compared to the control (P<0.05). Treatment with 400mg/kg SBECC (Group D) significantly increased serum Alkaline phosphatase (224.00±12.88iu/l) and creatinine levels (85.60±7.40) when compared to the control (140.00±26.47 and 63.60±7.60 respectively) (P<0.05), whereas treatment with 200mg/kg SBECC significantly increased urea and creatinine levels (P<0.05). No significant changes were observed in the haematological parameters of the treated rats compared to the control. Conclusion: Sub-acute oral administration of Cinnamomum cassia stem bark extract at doses lower than 500 mg/kg may not exert toxic effects on haematological parameters but can alter some serum biochemical parameters in rats.

scholarly journals Effects of Salacia lehmbachii ethanol root bark extract on estrous cycle and sex hormones of female albino rats

2018 ◽  
Vol 7 (6) ◽  
pp. 274
Author(s):  
GodwinC Akuodor ◽  
GraceA Essiet ◽  
DanielOJ Aja ◽  
MathewO Nwokike ◽  
DesmondO Eke ◽  
...  
Keyword(s):  
Estrous Cycle ◽  
Sex Hormones ◽  
Bark Extract ◽  
Albino Rats ◽  
Root Bark

Effect of Ethanol Root Bark Extract of Salacia lehmbachii Loes on Male Reproductive Hormones in Albino Rats

2016 ◽  
Vol 15 (3) ◽  
pp. 1-7
Author(s):  
Grace Essiet ◽  
Augustine Essien ◽  
Godwin Akuodor ◽  
Francis Udoh ◽  
Akanimo Essiet
Keyword(s):  
Reproductive Hormones ◽  
Bark Extract ◽  
Albino Rats ◽  
Root Bark

Diabetogenic Potential of Dexamethasone and Effect of Annona Muricata Methanolic Bark Extract as Post-exposure Therapy in Albino Rats

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 131-LB
Author(s):  
TUNBOSUN A. OLADIPO ◽  
YEMISI D. ADEOYE ◽  
OLUWAMAYOWA O. OLADIPO ◽  
JOHNNY O. OLUKUNLE
Keyword(s):  
Exposure Therapy ◽  
Bark Extract ◽  
Albino Rats ◽  
Annona Muricata ◽  
Post Exposure
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