scholarly journals PHYTOCHEMICAL SCREENING AND ANTIDIARRHEAL ACTIVITY OF ETHANOLIC FRESH ROOT BARK EXTRACT OF MONDIA WHITEI IN ALBINO RATS

2013 ◽  
Vol 2 (6) ◽  
pp. 1-6 ◽  
Author(s):  
Ndukui James Gakunga ◽  
Larry Fred Sembajwe ◽  
John Kateregga ◽  
Vudriko Patrick
Keyword(s):  
Bark Extract ◽  
Albino Rats ◽  
Root Bark ◽  
Phytochemical Screening ◽  
Antidiarrheal Activity ◽  
Fresh Root

scholarly journals Contraceptive Activity of Vitex doniana Stem Bark Methanol Extract in Female Albino Rats

2021 ◽  
Author(s):  
Angela Nnenna Ukwuani-Kwaja ◽  
Ibrahim Sani ◽  
Abdulhamid Zubairu
Keyword(s):  
Methanol Extract ◽  
Stem Bark ◽  
Bark Extract ◽  
Albino Rats ◽  
Modern Contraceptive ◽  
Phytochemical Screening ◽  
Control Serum ◽  
Stem Bark Extract ◽  
Vitex Doniana ◽  
Hormonal Assay

Aims: The acceptability and accessibility of modern contraceptive drugs are limited especially in northern Nigeria. These contraceptives also have numerous side effects hence there is need to search for safe natural alternatives from medicinal plants. This research was aimed at evaluating the contraceptive effect of stem bark methanol extract of Vitex doniana in female albino rats. Place and Duration of Study: Department of Biochemistry, Faculty of Life Science, Kebbi State University of Science and Technology Aliero, Kebbi State, Nigeria. Between August 2019 to July 2020. Methodology: Vitex doniana stem bark was extracted with methanol and the extract was subjected to qualitative phytochemical screening. Acute toxicity (LD50) of V. doniana stem bark extract was determined using up and down method and anti-fertility effect was evaluated via (anti-ovulation, anti-implantation and serum hormonal assay). Results: The results for phytochemical screening showed the presence of alkaloids, flavonoids, tannins, steroids, glycoside, balsam and volatile oil. The LD50 of the extract was estimated to be greater than 5000 mg/kg as no mortality or any sign of toxicity are recorded within 14 days. The anti-fertility studies, methanol stem bark extract of Vitex doniana showed anti-ovulation activity through alteration of estrous cycle, changes in the histology of ovarian corpus luteum and decreasing number of follicles of extract treatment groups compared to control. Serum hormonal assay showed significant decrease (P<0.05) in oestrogen and progesterone level respectively in the extract treated groups compared to control group. Also, anti-implantation effect was observed in drug treated group (levenogesterel) and group treated with 400 mg/kg of V. doniana stem bark as there was no evidence of conception. Conclusion: The present study revealed that methanol stem bark extract of Vitex doniana is relatively nontoxic at acute dose and possess a moderate amount of antifertility agent.

Effect of administration of methanol root bark extract of Cussonia arborea on serum lipid profile and oxidative biomarker parameters in alloxan-induced diabetic rats

2016 ◽  
Author(s):  
Patrick Emeka Aba ◽  
Isaac Uzoma Asuzu
Keyword(s):  
Oxidative Stress ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Methanol Extract ◽  
Diabetic Rats ◽  
Bark Extract ◽  
Albino Rats ◽  
Root Bark ◽  
Oxidative Stress Biomarkers ◽  
And Oxidative Stress

This study investigated the effects of methanol extract of Cussonia arborea on serum lipid and oxidative stress biomarkers of alloxan-induced diabetic rats. A total of 72 male albino rats assigned into 6 groups of 12 rats per group were used. Groups 1-5 were made diabetic while group 6 were normal. Groups 1-4 were treated with 62.5, 125, 250 mg/kg of the extract and 2 mg/kg glibenclamide respectively while groups 5 and 6 received 10 ml/kg distilled water each. Total cholesterol, triglyceride, high density lipoprotein (HDL), malondiadehyde, catalase, and superoxide dismutase (SOD) were assayed on days 28, 56 and 84 post treatment. The results indicated that the extract significantly (p<0.05) reduced the levels of total cholesterol, triglyceride, malondialdehyde but significantly (p<0.05) increased the activities of SOD, catalase and the levels of HDL when compared to negative control. It was therefore concluded that methanol extract of C. arborea mitigated dyslipidaemia and oxidative stress.

scholarly journals Effects of Salacia lehmbachii ethanol root bark extract on estrous cycle and sex hormones of female albino rats

2018 ◽  
Vol 7 (6) ◽  
pp. 274
Author(s):  
GodwinC Akuodor ◽  
GraceA Essiet ◽  
DanielOJ Aja ◽  
MathewO Nwokike ◽  
DesmondO Eke ◽  
...  
Keyword(s):  
Estrous Cycle ◽  
Sex Hormones ◽  
Bark Extract ◽  
Albino Rats ◽  
Root Bark

Effect of Ethanol Root Bark Extract of Salacia lehmbachii Loes on Male Reproductive Hormones in Albino Rats

2016 ◽  
Vol 15 (3) ◽  
pp. 1-7
Author(s):  
Grace Essiet ◽  
Augustine Essien ◽  
Godwin Akuodor ◽  
Francis Udoh ◽  
Akanimo Essiet
Keyword(s):  
Reproductive Hormones ◽  
Bark Extract ◽  
Albino Rats ◽  
Root Bark
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