Histomorphological Effect of the Aqueous Root-Bark Extract of Ficus sycomorus (Linn) on the Liver and Kidney of Albino Rats

2006 ◽  
Vol 2 (6) ◽  
pp. 628-632 ◽  
Author(s):  
S.H. Garba . ◽  
J. Prasad . ◽  
U.K. Sandabe .
Keyword(s):  
Bark Extract ◽  
Albino Rats ◽  
Root Bark ◽  
Liver And Kidney ◽  
Ficus Sycomorus

Effect of administration of methanol root bark extract of Cussonia arborea on serum lipid profile and oxidative biomarker parameters in alloxan-induced diabetic rats

2016 ◽  
Author(s):  
Patrick Emeka Aba ◽  
Isaac Uzoma Asuzu
Keyword(s):  
Oxidative Stress ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Methanol Extract ◽  
Diabetic Rats ◽  
Bark Extract ◽  
Albino Rats ◽  
Root Bark ◽  
Oxidative Stress Biomarkers ◽  
And Oxidative Stress

This study investigated the effects of methanol extract of Cussonia arborea on serum lipid and oxidative stress biomarkers of alloxan-induced diabetic rats. A total of 72 male albino rats assigned into 6 groups of 12 rats per group were used. Groups 1-5 were made diabetic while group 6 were normal. Groups 1-4 were treated with 62.5, 125, 250 mg/kg of the extract and 2 mg/kg glibenclamide respectively while groups 5 and 6 received 10 ml/kg distilled water each. Total cholesterol, triglyceride, high density lipoprotein (HDL), malondiadehyde, catalase, and superoxide dismutase (SOD) were assayed on days 28, 56 and 84 post treatment. The results indicated that the extract significantly (p<0.05) reduced the levels of total cholesterol, triglyceride, malondialdehyde but significantly (p<0.05) increased the activities of SOD, catalase and the levels of HDL when compared to negative control. It was therefore concluded that methanol extract of C. arborea mitigated dyslipidaemia and oxidative stress.

scholarly journals Acute and Sub-chronic Toxicity Studies on Methanol Stem Bark Extract of Frankincense Tree (Boswellia dalzielii) and Leaves Extract of Kenaf (Hibiscus cannabinus)

2021 ◽  
pp. 33-38
Author(s):  
S. Salihu ◽  
C. A. Otitolaiye ◽  
M. U. Hizbullah
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Chronic Toxicity ◽  
Stem Bark ◽  
Toxicity Study ◽  
Bark Extract ◽  
Albino Rats ◽  
Liver And Kidney ◽  
Stem Bark Extract ◽  
Oral Acute Toxicity

Aim: Frankincense tree (Boswellia dalzielii) and Kenaf (H. cannabinus) are plants abundantly found in north-western Nigeria. These plants are very popular among the locals as potent sources of ethno medicine. The present study investigates the oral acute toxicity potentials of methanolic stem bark extract of frankincense tree and Kenaf leaves, as well as sub-chronic toxicity potentials of the plants extracts on the kidney and liver of Albino rats. Study Design: Laboratory-experimental design was used for this study. Place and Duration of Study: This study was carried out between September 2019 and November 2019 at Biochemistry laboratory, Sokoto State University, Sokoto, Nigeria. Methodology: For the oral acute toxicity study, the revised “Up and Down” test (Limit Dose Test) was used to determine the LD50 of the extracts. For sub-chronic toxicity study, twenty albino rats were used for each plant, and were divided into four groups of five animals each. Group I (control), Group II (received 200 mg extract/kg body weight), Group III (received 400 mg extract/kg body weight) and Group IV (received 800 mg extract/kg body weight). All administrations were given orally for 28 days. Liver and kidney markers were determined using standard methods. Result: The oral acute toxicity test of the plant extracts at 3000 mg/kg body weight showed no mortality for 24 hours and subsequent 14days of administration. LD50 for both plants is therefore greater than 3000 mg/kg. The result shows no significant differences (p > 0.05) on liver and kidney function biomarkers investigated when Group II, III and IV are compared with control. Conclusion: This suggests that Frankincense stem bark and kenaf leaves extracts may be safe in rats at doses less than or equal 3000 mg/kg.

scholarly journals Effects of Salacia lehmbachii ethanol root bark extract on estrous cycle and sex hormones of female albino rats

2018 ◽  
Vol 7 (6) ◽  
pp. 274
Author(s):  
GodwinC Akuodor ◽  
GraceA Essiet ◽  
DanielOJ Aja ◽  
MathewO Nwokike ◽  
DesmondO Eke ◽  
...  
Keyword(s):  
Estrous Cycle ◽  
Sex Hormones ◽  
Bark Extract ◽  
Albino Rats ◽  
Root Bark
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