scholarly journals Near-infrared probes for luminescence lifetime imaging

2022 ◽  
Vol 6 (1) ◽  
pp. 91-102
Author(s):  
Benhao Li ◽  
Jing Lin ◽  
Peng Huang ◽  
Xiaoyuan Chen
Keyword(s):  
Near Infrared ◽  
Luminescence Lifetime ◽  
Lifetime Imaging ◽  
Infrared Probes

N,O-Benzamide difluoroboron complexes as near-infrared probes for the detection of β-amyloid and tau fibrils

2020 ◽  
Vol 56 (53) ◽  
pp. 7269-7272
Author(s):  
Yimin Chen ◽  
Chang Yuan ◽  
Tianxin Xie ◽  
Yuying Li ◽  
Bin Dai ◽  
...  
Keyword(s):  
Near Infrared ◽  
Β Amyloid ◽  
Infrared Probes ◽  
Tau Fibrils

In this study, a series of organo difluoroboron probes with a BF2 benzamide moiety was designed, prepared and evaluated as Aβ and Tau probes.

scholarly journals Biocompatible Ir(III) Complexes as Oxygen Sensors for Phosphorescence Lifetime Imaging

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2898
Author(s):  
Ilya S. Kritchenkov ◽  
Anastasia I. Solomatina ◽  
Daria O. Kozina ◽  
Vitaly V. Porsev ◽  
Victor V. Sokolov ◽  
...  
Keyword(s):  
Near Infrared ◽  
Biological Systems ◽  
Aqueous Media ◽  
Oxygen Sensors ◽  
Quantum Yields ◽  
Complete Agreement ◽  
Phosphorescence Lifetime ◽  
Lifetime Imaging ◽  
Nir Emission ◽  
Phosphorescence Lifetime Imaging

Synthesis of biocompatible near infrared phosphorescent complexes and their application in bioimaging as triplet oxygen sensors in live systems are still challenging areas of organometallic chemistry. We have designed and synthetized four novel iridium [Ir(N^C)2(N^N)]+ complexes (N^C–benzothienyl-phenanthridine based cyclometalated ligand; N^N–pyridin-phenanthroimidazol diimine chelate), decorated with oligo(ethylene glycol) groups to impart these emitters’ solubility in aqueous media, biocompatibility, and to shield them from interaction with bio-environment. These substances were fully characterized using NMR spectroscopy and ESI mass-spectrometry. The complexes exhibited excitation close to the biological “window of transparency”, NIR emission at 730 nm, and quantum yields up to 12% in water. The compounds with higher degree of the chromophore shielding possess low toxicity, bleaching stability, absence of sensitivity to variations of pH, serum, and complex concentrations. The properties of these probes as oxygen sensors for biological systems have been studied by using phosphorescence lifetime imaging experiments in different cell cultures. The results showed essential lifetime response onto variations in oxygen concentration (2.0–2.3 μs under normoxia and 2.8–3.0 μs under hypoxia conditions) in complete agreement with the calibration curves obtained “in cuvette”. The data obtained indicate that these emitters can be used as semi-quantitative oxygen sensors in biological systems.

scholarly journals Iridium Nanoparticles for Multichannel Luminescence Lifetime Imaging, Mapping Localization in Live Cancer Cells

2018 ◽  
Vol 140 (32) ◽  
pp. 10242-10249 ◽  
Author(s):  
Siobhan M. King ◽  
Sunil Claire ◽  
Rodolfo I. Teixeira ◽  
Abiola N. Dosumu ◽  
Andrew J. Carrod ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Luminescence Lifetime ◽  
Iridium Nanoparticles ◽  
Lifetime Imaging

scholarly journals Fluorescence lifetime imaging of upper gastrointestinal pH in vivo with a lanthanide based near-infrared τ probe

2019 ◽  
Vol 10 (15) ◽  
pp. 4227-4235 ◽  
Author(s):  
Yingying Ning ◽  
Shengming Cheng ◽  
Jing-Xiang Wang ◽  
Yi-Wei Liu ◽  
Wei Feng ◽  
...  
Keyword(s):  
Fluorescence Lifetime ◽  
Near Infrared ◽  
Lanthanide Complex ◽  
Fluorescence Lifetime Imaging ◽  
Ph Responsive ◽  
Gastrointestinal Ph ◽  
Lifetime Imaging ◽  
Upper Gastrointestinal

Lanthanide complex was successfully applied in the design of pH-responsive NIR τ probe for quantitative in vivo imaging.

scholarly journals Luminescence Lifetime Imaging of O2 with a Frequency-Domain-Based Camera System

10.3791/60191 ◽  
2019 ◽  
Author(s):  
Maria Moßhammer ◽  
Vincent V. Scholz ◽  
Gerhard Holst ◽  
Michael Kühl ◽  
Klaus Koren
Keyword(s):  
Frequency Domain ◽  
Luminescence Lifetime ◽  
Camera System ◽  
Lifetime Imaging

A modular luminescence lifetime imaging system for mapping oxygen distribution in biological samples

1998 ◽  
Vol 51 (1-3) ◽  
pp. 163-170 ◽  
Author(s):  
Gerhard Holst ◽  
Oliver Kohls ◽  
Ingo Klimant ◽  
Bettina König ◽  
Michael Kühl ◽  
...  
Keyword(s):  
Biological Samples ◽  
Imaging System ◽  
Luminescence Lifetime ◽  
Oxygen Distribution ◽  
Lifetime Imaging
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