Formation and selected catalytic properties of ruthenium, rhodium, osmium and iridium nanoparticles

The synthesis and applications in catalysis of nanoparticles formed from ruthenium, rhodium, osmium and iridium have been reviewed.

The enzymatic performance derived from the lattice planes of Ir nanoparticles

Iridium nanoparticles (IrNPs) have shown intriguing enzyme-like activities, however, the mechanism behind their versatile enzymatic behaviors is still elusive. A new kind of IrNPs stabilized with β-cyclodextrin (CD) was prepared...

Cross β-alkylation of primary alcohols catalysed by DMF-stabilized iridium nanoparticles

A simple method for the cross β-alkylation of linear alcohols with benzyl alcohols in the presence of DMF-stabilized iridium nanoparticles was developed. Furthermore, a highly effective catalyst-recycling process was also developed.

Biokinetic modeling of nanoparticle interactions with lung alveolar epithelial cells: uptake, intracellular processing, and egress

Studies on health effects of engineered nanomaterials (ENMs) in the lung have provided information on ENM toxicity and translocation across airway and alveolar epithelial barriers. Various inhaled ENMs (e.g., gold and iridium nanoparticles) have been reported to partially cross the air-blood barrier in the lung, enter the vasculature, and distribute in several end organs, including the heart, liver, spleen, and kidney. Using an in vitro primary rat alveolar epithelial cell (AEC) monolayer model, we reported transport rates of relatively nontoxic polystyrene nanoparticles (PNPs), which appear to be taken up via nonendocytic processes into AECs. PNPs internalized into cytoplasm then trigger autophagy, followed by delivery of PNPs from autophagosomes into lysosomes, from where PNPs are exocytosed. We used the data from these experiments to perform biokinetic modeling that incorporates the processes associated with internalization and intracellular distribution of PNPs, autophagy, lysosomal exocytosis of PNPs, and several putative mechanisms of action that extend our previous understanding of AEC processing of PNPs. Results suggest that entry of PNPs into AECs, subsequent activation of autophagy by cytosolic PNPs, accumulation of PNPs in lysosomes, and lysosomal exocytosis are interwoven by proposed regulatory mechanisms.