scholarly journals Anticonvulsant activity of butanol fraction of methanol root bark extract of Securinega virosa Roxb (ex Willd) Baill. in laboratory animals

2013 ◽  
Vol 7 (28) ◽  
pp. 2128-2135 ◽  
Author(s):  
G Magaji M ◽  
H Yaro A ◽  
M Musa A ◽  
A Anuka J ◽  
Abdu Aguye I ◽  
...  
Keyword(s):  
Anticonvulsant Activity ◽  
Laboratory Animals ◽  
Bark Extract ◽  
Root Bark ◽  
Butanol Fraction ◽  
Securinega Virosa

Anticonvulsant activity of Carissa edulis (Vahl) (Apocynaceae) root bark extract

2008 ◽  
Vol 120 (2) ◽  
pp. 255-258 ◽  
Author(s):  
J. Ya’u ◽  
A.H. Yaro ◽  
M.S. Abubakar ◽  
J.A. Anuka ◽  
I.M. Hussaini
Keyword(s):  
Anticonvulsant Activity ◽  
Bark Extract ◽  
Root Bark

Central depressant activity of butanol fraction of Securinega virosa root bark in mice

2012 ◽  
Vol 141 (1) ◽  
pp. 128-133 ◽  
Author(s):  
Mohammed Garba Magaji ◽  
Abdullahi Hamza Yaro ◽  
Aliyu Muhammad Musa ◽  
Joseph Akponso Anuka ◽  
Ibrahim Abdu-Aguye ◽  
...  
Keyword(s):  
Root Bark ◽  
Butanol Fraction ◽  
Securinega Virosa ◽  
Central Depressant

Evaluation of the antipsychotic potential of aqueous fraction of Securinega virosa root bark extract in mice

2014 ◽  
Vol 29 (1) ◽  
pp. 161-165 ◽  
Author(s):  
M. G. Magaji ◽  
M. Mohammed ◽  
R. A. Magaji ◽  
A. M. Musa ◽  
I. Abdu-Aguye ◽  
...  
Keyword(s):  
Bark Extract ◽  
Root Bark ◽  
Aqueous Fraction ◽  
Securinega Virosa

scholarly journals Evaluation of Anticonvulsant Activity of 80% Methanolic Root Bark Extract and Solvent Fractions of Pentas schimperiana (A. Rich.) Vatke (Rubiaceae) in Swiss Albino Mice

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Nebeyi Fisseha ◽  
Workineh Shibeshi ◽  
Daniel Bisrat
Keyword(s):  
Anticonvulsant Activity ◽  
Bark Extract ◽  
Anticonvulsant Effect ◽  
Chloroform Fraction ◽  
Therapeutic Effects ◽  
Maximal Electroshock ◽  
Root Bark ◽  
Aqueous Fraction ◽  
Potential Source ◽  
Substantial Morbidity

Background. Epilepsy is one of the most common serious neurological disorders, responsible for substantial morbidity and mortality due to limited efficacy and negative properties of antiepileptic drugs. Medicinal plants are believed to be an important source of new chemical substances with potential therapeutic effects. Pentas schimperiana (A. Rich.) Vatke is a medicinal plant used in Ethiopian traditional medicine for the treatment of epilepsy. However, it lacks scientific investigation on its anticonvulsant activity. Therefore, this study was conducted to evaluate the anticonvulsant activity of 80% methanol root bark extract and solvent fractions of Pentas schimperiana (A. Rich.) Vatke in mice. Methods. Anticonvulsant activity was evaluated by using the pentylenetetrazole and maximal electroshock-induced seizure test. The 80% methanolic root bark extract was subjected to successive fractionation with solvents differing polarity, i.e., chloroform, butanol, and water. The test groups received 100, 200, and 400 mg/kg bodyweight of extract and its solvent fractions. Result. The ME400 and BF400 at the higher dose exhibited a significant ( p < 0.001 ) anticonvulsant effect in both the pentylenetetrazole and maximal electroshock-induced seizure test compared with control. However, chloroform fraction only showed a significant ( p < 0.001 ) anticonvulsant effect in the PTZ-induced seizure test, while aqueous fraction had least anticonvulsant activity in both seizure-induced tests. Phytochemical screening of Pentas schimperiana (A. Rich.) Vatke root bark extract revealed the presence of alkaloids, saponins, flavonoids, phenols, steroids, terpenoids, and tannins. Conclusion. This study indicated that the plant has anticonvulsant activity and is considered as a potential source to develop a new antiepileptic drug.

scholarly journals Securinega virosa (Euphorbiaceae) root bark extract inhibits glioblastoma multiforme cell survival in vitro

2015 ◽  
Vol 9 (27) ◽  
pp. 684-693
Author(s):  
Mohammed Garba Magaji ◽  
Jamilu Yau ◽  
Aliyu Muhammad Musa ◽  
Joseph Akpojo Anuka ◽  
Ibrahim Abdu Aguye ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Cell Survival ◽  
Bark Extract ◽  
Root Bark ◽  
Securinega Virosa
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