scholarly journals Phytochemical constituents and effects of aqueous root-bark extract of Ficus sycomorus L. (Moracaea) on muscular relaxation, anaesthetic and sleeping time on laboratory animals

2009 ◽  
Vol 8 (21) ◽  
pp. 6004-6006 ◽  
Author(s):  
G Zaku S ◽  
A Abdulrahaman F ◽  
A Onyeyili P ◽  
C Aguzue O ◽  
A Thomas S
Keyword(s):  
Laboratory Animals ◽  
Bark Extract ◽  
Root Bark ◽  
Sleeping Time ◽  
Muscular Relaxation ◽  
Phytochemical Constituents ◽  
Ficus Sycomorus

scholarly journals Preliminary Phytochemical Analysis and In vitro Antimicrobial Study of the Root and Stem Bark Extracts of Ficus sycomorus Linn

2019 ◽  
pp. 1-10
Author(s):  
I. Toma ◽  
D. Dahiru ◽  
M. A. Madusolumou
Keyword(s):  
Stem Bark ◽  
Antimicrobial Activities ◽  
Reducing Sugar ◽  
Bark Extract ◽  
Phytochemical Analysis ◽  
Root Bark ◽  
Antimicrobial Studies ◽  
Stem Bark Extract ◽  
Ficus Sycomorus

This study was conducted to carryout preliminary phytochemical analysis and in vitro antimicrobial activities of aqueous and ethanolic root and stem bark extracts of Ficus sycomorus. Qualitative phytochemical analysis for tannins, saponin, terpenoids, flavonoids, alkaloids, glycosides, steroids, phenols, and reducing sugar was done using standard methods. The antimicrobial activities of the extracts were tested against four micro- organisms; Escherichia coli, Staphylococcus aureus, Shigella dysentrae, and Salmonella typhi. Agar well diffusion method was used for the antimicrobial studies. Phytochemical screening of both root and stem bark aqueous extracts showed the presence of tannin, saponin, terpenoid, flavonoid, alkaloids,  glycoside, steroid, reducing sugar, and phenol. Glycoside was not detected in both the aqueous and ethanolic extracts of the root bark. The result of the antimicrobial studies showed that the aqueous root extract have higher antimicrobial activity ranging from (2-12 mm) on the tested microorganisms than aqueous stem bark extract (3-9 mm), while for ethanol extract both stem and root bark extract has almost the same effect or antimicrobial activity on the tested pathogens ranging from (2-15 mm) which is having higher activity compared to the aqueous extracts. The Minimum inhibitory concentration (MIC) and Minimum bactericidal concentration (MBC) of both the extracts were found to be 50 mg/mL and 100 mg/mL respectively.  From this study, it can, therefore, be concluded that the root and stem bark extract is a potential antimicrobial agent which support the claim of the traditional users of this plant in herbal medicine for the treatment of diseases that are of microbial origin.

scholarly journals Vascular Protection by Ethanol Extract of Morus alba Root Bark: Endothelium-Dependent Relaxation of Rat Aorta and Decrease of Smooth Muscle Cell Migration and Proliferation

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Nisha Panth ◽  
Keshav Raj Paudel ◽  
Dal-Seong Gong ◽  
Min-Ho Oak
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Morus Alba ◽  
Guanosine Monophosphate ◽  
Current Evidence ◽  
Bark Extract ◽  
Root Bark ◽  
Natural Medicine ◽  
And Migration ◽  
Proliferation And Migration

Morus alba (white mulberry) is native to the northern part of Korea and popularly used as a traditional medicine due to its numerous health benefits against human’s disease. However, the possibility that M. alba may also affect the cardiovascular system remains unexplored. This study sought to investigate the vascular protective effects of the root bark extract of M. alba (MAE). Vascular reactivity was performed in organ baths using isolated rat thoracic aorta, while platelet derived growth factor (PDGF) induced proliferation and migration of vascular smooth muscle cells (VSMCs) were studied by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) and wound healing assay, respectively. MAE evoked a concentration dependent vasorelaxation following endothelium-dependent pathway. However, vessel relaxations in response to MAE were markedly reduced after endothelium removal; treatment of endothelial nitric oxide synthase inhibitor, guanylyl cyclase inhibitor, and nonspecific potassium channel inhibitor, however, was not altered by cyclooxygenase inhibitor. Furthermore, MAE also significantly blunted contractile response to vasoconstrictor agent, phenylephrine. Taken together, the current evidence revealed that MAE is a potent endothelium-dependent vasodilator and this effect was involved in, at least in part, nitric oxide cyclic-guanosine monophosphate (NO-cGMP) pathway in combination with potassium (K+) channel activation. Moreover, MAE inhibited proliferation and migration of VSMCs induced by PDGF. Therefore, MAE could be a promising candidate of natural medicine for preventing and controlling cardiovascular diseases linked with endothelial dysfunction.

scholarly journals Bacteriostatic and Bactericidal effects of ethyl acetate root bark extract of Terminalia avicennioides on Methicillin-resistant Staphylococcus aureus

2018 ◽  
Vol 12 (5) ◽  
pp. 45-54
Author(s):  
Ekene Ugochukwu Adim ◽  
Emeka John Dingwoke ◽  
Fatima Amin Adamude ◽  
Chidi Edenta ◽  
Ndubuisi Nwobodo Nwobodo ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Ethyl Acetate ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Bark Extract ◽  
Root Bark ◽  
Methicillin Resistant ◽  
Bactericidal Effects

Effect of Morus alba root bark extract on gene-level expression of inflammatory markers in rats subjected to ethanol and cerulein induced pancreatitis– influence of heat shock protein 70

2018 ◽  
Vol 16 (2) ◽  
Author(s):  
Kavitha Yuvaraj ◽  
Arumugam Geetha
Keyword(s):  
Oxidative Stress ◽  
Heat Shock ◽  
Morus Alba ◽  
Bark Extract ◽  
Root Extract ◽  
Root Bark ◽  
Nf Kappa B ◽  
Serum Lipase ◽  
Hsp70 Mrna ◽  
Caspase 1

Abstract Background Chronic pancreatitis (CP) is a persistent inflammation of the pancreas clinically presented with severe abdominal pain, progressive fibrosis, and loss of exocrine and endocrine functions. Inflammasomes, cytosolic multiprotein complexes which regulate the formation of proinflammatory cytokines, are influenced by various factors including heat shock proteins (HSPs). Morus alba L., or white mulberry root bark is a valued traditional Asian medicine with a diverse array of phytochemicals. The aim of this investigation was to define the modulatory action of methanolic extract of Morus alba root bark (MEMARB) on NLRP3 inflammasome, and HSPs in pancreas subjected to inflammatory insult. Methods Pancreatitis was induced in male albino Wistar rats by ethanol (0–36%) and cerulein (20 µg/kg b.wt., i.p.) for 5 weeks with or without MEMARB administration. Serum lipase/amylase (L/A) ratio, oxidative stress index (OSI) and reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio in the pancreas were evaluated. Levels of serum HSP70 was quantified by ELISA. NF-kappa B, NLRP3-ASC, caspase-1, IL-1β, IL-18, and HSP70 gene expression was quantified by quantitative real-time polymerase chain reaction (qPCR). Results L/A ratio and oxidative stress determined in terms of OSI and GSH/GSSG ratio were elevated in pancreatitis-induced rats. The levels were restored in MEMARB co-administered animals. Serum level of HSP70 was increased in pancreatitis-induced animals and dropped significantly in MEMARB co-administrated rats. Pancreatitis-induced group showed increased expression of NF-kappa B, IL-1β, IL-18, caspase-1, NLRP3-ASC and HSP70 mRNA than in MEMARB treated group. Conclusions It can be concluded that the M. alba root extract modulates the expression of HSP70 and NLRP3-ASC which might be attributed to its pancreato-protective effect.

scholarly journals Some behavioural studies on methanol root bark extract of Burkea africana (fabaceae) in mice

2016 ◽  
Vol 8 (2) ◽  
pp. 216 ◽  
Author(s):  
AH Yaro ◽  
S Malami ◽  
J Yau ◽  
CN Sagoe ◽  
JA Anuka
Keyword(s):  
Bark Extract ◽  
Root Bark
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