scholarly journals Securinega virosa (Euphorbiaceae) root bark extract inhibits glioblastoma multiforme cell survival in vitro

2015 ◽  
Vol 9 (27) ◽  
pp. 684-693
Author(s):  
Mohammed Garba Magaji ◽  
Jamilu Yau ◽  
Aliyu Muhammad Musa ◽  
Joseph Akpojo Anuka ◽  
Ibrahim Abdu Aguye ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Cell Survival ◽  
Bark Extract ◽  
Root Bark ◽  
Securinega Virosa

scholarly journals In vitro and in vivo evaluation of antibacterial activity of Bridelia ferruginea extracts on some clinical isolates

2018 ◽  
Vol 7 (4) ◽  
pp. 392-398
Author(s):  
B.T Yunana ◽  
◽  
B. B Bukar ◽  
J. C Aguiyi ◽  
◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Bark Extract ◽  
Root Extract ◽  
Root Bark ◽  
Zone Of Inhibition ◽  
Bridelia Ferruginea

The ethanol extracts of root, bark and leaf of Bridelia ferruginea was investigated for antibacterial activity against clinical isolate of Staphylococcus aureus and Escherichia coli. The extracts had significant antibacterial activity in vitro at concentration of 25 mg/ml, 50 mg/ml, 100 mg/ml and 200 mg/ml and in vivo at dose of 50 mg/kg and 100 mg/kg. The root extract in vitro had the highest zone of inhibition, followed by the bark extract for both Staphylococcus aureus and Escherichia coli. The concentration of 200 mg/ml had the highest zone of inhibition in vitro. The minimum inhibitory concentration (MIC) showed a decreasing inhibitory effect of the plant extracts for both Staphylococcus aureus and Escherichia coli as the concentration decreases with root having 3.125 mg/ml, bark having 6.25 mg/ml and leaf having 25 mg/ml for Staphylococcus aureus and Escherichia coli. Likewise, the minimum bactericidal concentration (MBC) showed decreasing bactericide effects with decrease concentration with root having 12.5 mg/ml, bark having 12.5 mg/ml and leaf having 25 mg/ml for Escherichia coli while root had 6.25mg/ml, bark had 12.5mg/ml and leaf had 25mg/ml for Staphylococcus aureus. The in vivo investigation showed that the root and bark extract exhibited antibacterial activity on both Staphylococcus aureus and Escherichia coli at doses of 100mg/kg and 50mg/kg; the root extract had higher activity than the bark and root/bark combined. The dose of 100 mg/kg had the highest colonies reduction for Staphylococcus aureus and Escherichia coli in vivo. Preliminary phytochemical screening of root, bark and leaves of Bridelia ferruginea revealed the presence of tannins, flavonoids, carbohydrates, cardiac glycoside (root, bark and leaves), saponins (root and bark). The presence of tannins, saponins, flavonoid, cardiac glycoside and carbohydrate in the bark and root extracts of the plant indicates that the bark and root extracts were pharmacological importance

In vitro antioxidant and anti-arthritic effect of the aqueous and ethanolic leaf and root bark extract of Alafia barteri

2021 ◽  
Vol 10 (1) ◽  
pp. 10-14
Author(s):  
Ikeoluwapo Olanike Kolawole ◽  
◽  
Osareti Albert Taiwo Ebuehi ◽  
Esther Ayomide Awoyera ◽  
◽  
...  
Keyword(s):  
Protein Denaturation ◽  
Reducing Power ◽  
Assay Method ◽  
Bark Extract ◽  
Root Extract ◽  
Root Bark ◽  
Eye Infections ◽  
Root Extracts ◽  
Ethanol Extracts

Alafia barteri (Apocynaceae) is a climbing shrub having white or pink flowers. Traditionally, it has been used to treat diseases like malaria, sickle cell anemia, and eye infections. This research is focused on investigating the antioxidant and anti-arthritic activities of the aqueous and ethanol leaf and root extract of Alafia barteri plant in vitro. In-vitro antioxidant methods used were 2, 2 -diphenyl-1-picrylhydrazyl assay, reducing power activity and hydrogen peroxide scavenging assay while the anti-arthritic activity was studied using the assay method of protein denaturation. Results revealed that aqueous and ethanol root extracts scavenge free radicals, thus inhibiting damage caused by oxidative stress in arthritis while the ethanol extracts of both the leaf and roots had good anti-arthritic activities as seen in its ability to decrease protein denaturation.

scholarly journals Effects of Juglans regia Root Bark Extract on Platelet Aggregation, Bleeding Time, and Plasmatic Coagulation: In Vitro and Ex Vivo Experiments

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
A. Amirou ◽  
M. Bnouham ◽  
A. Legssyer ◽  
A. Ziyyat ◽  
M. Aziz ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Bleeding Time ◽  
Ex Vivo ◽  
Juglans Regia ◽  
Anticoagulant Effect ◽  
Bark Extract ◽  
Root Bark ◽  
Thrombin Time ◽  
Induced Aggregation

Platelets have an important role in thrombosis and haemostasis. Hyperactivity of the platelets has been associated with thromboembolic diseases and represents the main cause of complications of cardiovascular diseases. Crude aqueous extract (CAE) of Juglans regia root bark was evaluated for bleeding time, antiaggregant activity by using agonists, thrombin, ADP, collagen, or arachidonic acid (in vitro and ex vivo), and anticoagulant activity by measuring the clotting parameters: activated partial thromboplastin time, prothrombin time, thrombin time, and fibrinogen dosage (in vitro and ex vivo). The result of this study reported that the strongest antiaggregant effect of CAE in vitro was observed on the ADP-induced aggregation with inhibitions up to 90 %, while, in ex vivo experiments, the inhibition (more than 80 %) was observed with all agonists. Anticoagulant effect of CAE significantly prolonged the TT and decreased the fibrinogen level in vitro and ex vivo without interfering with APTT and PT. The bleeding time in mice and rats was significantly increased by CAE. The antiplatelet and anticoagulant effect observed in this study suggest that Juglans regia could have antithrombotic and/or thrombolytic activities and provide an alternative therapy against thrombotic complications related to cardiovascular diseases.

scholarly journals Chemical profiling of root bark extract from Oplopanax elatus and its in vitro biotransformation by human intestinal microbiota

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e12513
Author(s):  
Jin-Yi Wan ◽  
Jing-Xuan Wan ◽  
Shilei Wang ◽  
Xiaolu Wang ◽  
Wenqian Guo ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
Ultra Performance Liquid Chromatography ◽  
Bark Extract ◽  
Chemical Components ◽  
Root Bark ◽  
Chemical Profiling ◽  
Human Intestinal Microbiota ◽  
Oplopanax Elatus ◽  
Main Components

Oplopanax elatus (Nakai) Nakai, in the Araliaceae family, has been used in traditional Chinese medicine (TCM) to treat diseases as an adaptogen for thousands of years. This study established an ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF/MS) method to identify chemical components and biotransformation metabolites of root bark extract from O. elatus. A total of 18 compounds were characterized in O. elatus extract, and 62 metabolites by human intestinal microbiota were detected. Two polyynes, falcarindiol and oplopandiol were recognized as the main components of O. elatus, whose metabolites are further illustrated. Several metabolic pathways were proposed to generate the detected metabolites, including methylation, hydrogenation, demethylation, dehydroxylation, and hydroxylation. These findings indicated that intestinal microbiota might play an essential role in mediating the bioactivity of O. elatus.

scholarly journals Evaluation of In-Vitro Antioxidant Activity of Root Bark Extracts of Ventilago Maderspatana Gaertn

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1636-1640
Author(s):  
Manish Deshmukh ◽  
Ashish Budhrani ◽  
Upendra Gandagule ◽  
Sanjay Nagdev ◽  
Mayur Bhurat ◽  
...  
Keyword(s):  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Bark Extract ◽  
Root Bark ◽  
Anti Oxidant ◽  
Biomedical Potential ◽  
Oxide Inhibition ◽  
In Vitro Antioxidant Activity

Ventilago maderspatana Gaertn. is a plant having enormous biomedical potential. It is a plant in the Indian system of medicine having a plethora of properties and applications and The root barks powder of Ventilago maderspatana Gaertn.  have many properties and applications like it are used as a stomachic, tonic, carminative, stimulant. It is also useful in the treatment of weakness and fever. For further investigations of activities like anti-oxidant activity, In-vitro  anti-oxidant studies were done on root bark extracts of Ventilago maderspatana Gaertn. (Family Rhamnaceae) by using standard methods like Lipid peroxidation Assay, Estimation of total anti-oxidant capacity (TAC), Hydroxyl radical scavenging activity, Nitric oxide inhibition radical activity by p-Nitroso dimethyl aniline method, and ABTS Radical scavenging method. The root barks of plant Ventilago maderspatana Gaertn. Were subjected to cold maceration process in 3-liter Round bottom flask using ethanol and distilled water and nature and yield was noted and stored at 40C in the refrigerator until further use and both the extracts were labelled as Ventilago maderspatana Gaertn. Root Bark aqueous (VMRBA) and Ventilago maderspatana Gaertn. Root Bark Ethanolic (VMRBE) for convenient identification. Ethanolic extract of Root Bark showed the more potent anti-oxidant activity than aqueous Root Bark extract of Ventilago maderspatana Gaertn.

Evaluation of the antipsychotic potential of aqueous fraction of Securinega virosa root bark extract in mice

2014 ◽  
Vol 29 (1) ◽  
pp. 161-165 ◽  
Author(s):  
M. G. Magaji ◽  
M. Mohammed ◽  
R. A. Magaji ◽  
A. M. Musa ◽  
I. Abdu-Aguye ◽  
...  
Keyword(s):  
Bark Extract ◽  
Root Bark ◽  
Aqueous Fraction ◽  
Securinega Virosa

scholarly journals In VivoAntimalarial Activity of the 80%Methanolic Root Bark Extract and Solvent Fractions ofGardenia ternifoliaSchumach. & Thonn. (Rubiaceae) againstPlasmodium berghei

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Dejen Nureye ◽  
Solomon Assefa ◽  
Teshome Nedi ◽  
Ephrem Engidawork
Keyword(s):  
Crude Extract ◽  
Antimalarial Activity ◽  
Standard Procedure ◽  
New Drugs ◽  
Bark Extract ◽  
Root Bark ◽  
Antimalarial Agents ◽  
Loss Of Weight

Background. Evolution of antimalarial drug resistance makes the development of new drugs a necessity. Important source in search of such drugs is medicinal plants.Gardenia ternifoliaplant is used in Ethiopian traditional medicine for the treatment of malaria and is endowed within vitroantimalarial activity. Herein, thein vivoantimalarial activity of the plant was investigated.Methods. Acute toxicity was carried out using a standard procedure. A 4-day suppressive test was employed to evaluate the antimalarial effect of methanolic crude extract and solvent fractions of the plant. The curative and prophylactic effect of crude extract was further tested by Ranes’s test and residual infection procedure, respectively, usingPlasmodium berghei(ANKA strain) in Swiss albino mice.Results. The chemosuppressive effect exerted by the crude extract and fractions ranged between 30-59% and 14-51%, respectively. Curative and prophylactic effects of the crude extract were in the range of 36-63% and 24-37%, respectively. All dose levels of the crude extract prevented loss of weight, reduction in temperature, and anemia on early and established infection. Butanol and chloroform fractions also did reverse reduction in temperature, body weight, and packed cell volume.Conclusions. The results indicated that the plant has a promising antiplasmodial activity and it could be considered as a potential source to develop new antimalarial agents.

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