scholarly journals Nano/Microparticles Encapsulation Via Covalent Drug Conjugation

2020 ◽  
Author(s):  
Victoria Fasiku ◽  
Edith K. Amuhaya ◽  
Kingo M. Rajab ◽  
Calvin A. Omolo
Keyword(s):  
Drug Conjugation

Wide application of a novel topoisomerase I inhibitor-based drug conjugation technology

2016 ◽  
Vol 26 (20) ◽  
pp. 5069-5072 ◽  
Author(s):  
Yusuke Ogitani ◽  
Yuki Abe ◽  
Takuma Iguchi ◽  
Junko Yamaguchi ◽  
Tomoko Terauchi ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Topoisomerase I Inhibitor ◽  
Drug Conjugation

Enhancing bacterial production of a recombinant cetuximab-Fab by partial humanization and its utility for drug conjugation

2018 ◽  
Vol 69 ◽  
pp. 123-130
Author(s):  
Dae-Won Sim ◽  
Jinsue Song ◽  
Ji-Hun Kim ◽  
Jun-Kyoung Lee ◽  
Da-Yoon Chung ◽  
...  
Keyword(s):  
Bacterial Production ◽  
Drug Conjugation

scholarly journals Self-Assembly of Thermally Responsive Nanoparticles of a Genetically Encoded Peptide Polymer by Drug Conjugation

2012 ◽  
Vol 52 (6) ◽  
pp. 1683-1687 ◽  
Author(s):  
Jonathan R. McDaniel ◽  
Jayanta Bhattacharyya ◽  
Kevin B. Vargo ◽  
Wafa Hassouneh ◽  
Daniel A. Hammer ◽  
...  
Keyword(s):  
Self Assembly ◽  
Thermally Responsive ◽  
Drug Conjugation

Metabolic Engineering of Monoclonal Antibody Carbohydrates for Antibody–Drug Conjugation

2013 ◽  
Vol 24 (10) ◽  
pp. 1650-1655 ◽  
Author(s):  
Nicole M. Okeley ◽  
Brian E. Toki ◽  
Xinqun Zhang ◽  
Scott C. Jeffrey ◽  
Patrick J. Burke ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Metabolic Engineering ◽  
Drug Conjugation ◽  
Antibody Drug

scholarly journals Antibody Based Therapies in Acute Leukemia

2017 ◽  
Vol 18 (3) ◽  
pp. 257-270 ◽  
Author(s):  
Nirali N. Shah
Keyword(s):  
Acute Leukemia ◽  
Chemotherapy Resistance ◽  
Antigen Expression ◽  
Alternative Mechanism ◽  
Drug Conjugation ◽  
Surface Antigen Expression ◽  
Novel Method ◽  
Cytotoxic Therapies ◽  
Leukemia In Children ◽  
The Ideal

Despite great progress in the curative treatment of acute leukemia, outcomes for those with relapsed and/or chemotherapy-refractory disease remain poor. Current intensive cytotoxic therapies can be associated with significant morbidity and novel therapies are needed to improve outcomes. Immunotherapy based approaches provide an alternative mechanism of action in the treatment of acute leukemia. Due to cell surface antigen expression, leukemia in particular is amenable to targeted therapies, such as antibody-based therapy. Based on the potential for non-overlapping toxicity, the possibility of synergistic action with standard chemotherapy, and by providing a novel method to overcome chemotherapy resistance, antibody-based therapies have shown potential for benefit. Modifications to standard monoclonal antibodies, including drug conjugation and linkage to T-cells, may further enhance efficacy of antibody-based therapies. Identifying the ideal timing for incorporation of antibody-based therapies, within standard regimens, may lead to improvement in overall outcomes. This article will provide an overview of antibody-based therapies in clinical development for the treatment of acute leukemia in children and adults, with a particular focus on the current strategies and future developments.

scholarly journals Influence of disulfide bond isoforms on drug conjugation sites in cysteine-linked IgG2 antibody-drug conjugates

mAbs ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 583-595 ◽  
Author(s):  
Lily Liu-Shin ◽  
Adam Fung ◽  
Arun Malhotra ◽  
Gayathri Ratnaswamy
Keyword(s):  
Disulfide Bond ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Drug Conjugation ◽  
Igg2 Antibody ◽  
Antibody Drug

Pediatric glioblastoma target-specific efficient delivery of gemcitabine across the blood–brain barrier via carbon nitride dots

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7927-7938 ◽  
Author(s):  
Piumi Y. Liyanage ◽  
Yiqun Zhou ◽  
Abdulrahman O. Al-Youbi ◽  
Abdulaziz S. Bashammakh ◽  
Mohammad S. El-Shahawi ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Carbon Nitride ◽  
Drug Efficacy ◽  
Effective Drug ◽  
Brain Barrier ◽  
Drug Conjugation ◽  
Blood Brain ◽  
Efficient Delivery ◽  
Pediatric Glioblastoma ◽  
Selective Target

A carbon nitride dot nanocarrier system with effective drug conjugation and selective target delivering to achieve enhanced drug efficacy on pediatric glioblastomas, while proving capability to penetrate blood–brain barrier.

Graft copolymers with tunable amphiphilicity tailored for efficient dual drug delivery via encapsulation and pH-sensitive drug conjugation

2020 ◽  
Vol 11 (27) ◽  
pp. 4438-4453
Author(s):  
Markéta Bláhová ◽  
Eva Randárová ◽  
Rafal Konefał ◽  
Benjamin Nottelet ◽  
Tomáš Etrych
Keyword(s):  
Drug Delivery ◽  
Graft Copolymers ◽  
Ph Sensitive ◽  
Solution Properties ◽  
High Drug ◽  
Drug Conjugation ◽  
Hydroxypropyl Methacrylamide ◽  
Dual Drug

Amphiphilic poly(ε-caprolactone)-graft-(poly-N-(2-hydroxypropyl) methacrylamide) copolymers with tunable solution properties form stable micelles with high drug payload via simultaneous encapsulation and pH-sensitive covalent conjugation.

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